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UniProtKB/Swiss-Prot entry P69942


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GLNE_MYCTU
Primary accession number P69942
Secondary accession number Q10379
Integrated into Swiss-Prot on January 4, 2005
Sequence was last modified on January 4, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 16)
Name and origin of the protein
Protein name Glutamate-ammonia-ligase adenylyltransferase
Synonyms EC 2.7.7.42
[Glutamate--ammonia-ligase] adenylyltransferase
Glutamine-synthetase adenylyltransferase
ATase
Gene name
Name: glnE
OrderedLocusNames: Rv2221c, MT2279
ORFNames: MTCY190.32c, MTCY427.02c
From
Mycobacterium tuberculosis [TaxID: 1773] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
DOI=10.1038/31159; PubMed=9634230 [NCBI, ExPASy, EBI, Israel, Japan]
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.";
Nature 393:537-544(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CDC 1551 / Oshkosh;
DOI=10.1128/JB.184.19.5479-5490.2002; PubMed=12218036 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.";
J. Bacteriol. 184:5479-5490(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX842579; CAA94664.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE000516; AAK46564.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A70776; A70776.
RefSeq NP_216737.1; -.
NP_336750.1; -.
3D structure databases
ModBase P69942.
Organism-specific databases
TubercuList Rv2221c; -.
Ontologies
GO
GO:0008882; Molecular function: [glutamate-ammonia-ligase] adenylyltransferase activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00802; -; 1.
PBIL [Tree]
InterPro IPR005190; GlnE.
Graphical view of domain structure.
Pfam PF03710; GlnE; 2.
Pfam graphical view of domain structure.
ProtoNet P69942.
Genome annotation databases
GeneID 887995; -.
924147; -.
GenomeReviews AE000516_GR; MT2279.
AL123456_GR; Rv2221c.
KEGG mtc:MT2279; -.
mtu:Rv2221c; -.
TIGR MT2279; -.
Phylogenomic databases
HOGENOM P69942; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Nucleotidyltransferase; Repeat; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   994  994     Glutamate-ammonia-ligase adenylyltransferase. PRO_0000209257
REGION   150   341  192     GlnE 1. 
REGION   645   852  208     GlnE 2. 
CONFLICT   676   676        T -> S (in Ref. 2; AAK46564). 
Sequence information
Length: 994 AA [This is the length of the unprocessed precursor] Molecular weight: 109138 Da [This is the MW of the unprocessed precursor] CRC64: 8E5EA5D63CCE25E0 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVVTKLATQR PKLPSVGRLG LVDPPAGERL AQLGWDRHED QAHVDLLWSL SRAPDADAAL 

        70         80         90        100        110        120 
RALIRLSENP DTGWDELNAA LLRERSLRGR LFSVLGSSLA LGDHLVAHPQ SWKLLRGKVT 

       130        140        150        160        170        180 
LPSHDQLQRS FVECVEESEG MPGSLVHRLR TQYRDYVLML AALDLAATVE DEPVLPFTVV 

       190        200        210        220        230        240 
AARLADAADA ALAAALRVAE ASVCGEHPPP RLAVIAMGKC GARELNYVSD VDVIFVAERS 

       250        260        270        280        290        300 
DPRNARVASE MMRVASAAFF EVDAALRPEG RNGELVRTLE SHIAYYQRWA KTWEFQALLK 

       310        320        330        340        350        360 
ARPVVGDAEL GERYLTALMP MVWRACERED FVVEVQAMRR RVEQLVPADV RGRELKLGSG 

       370        380        390        400        410        420 
GLRDVEFAVQ LLQLVHARSD ESLRVASTVD ALAALGEGGY IGREDAANMT ASYEFLRLLE 

       430        440        450        460        470        480 
HRLQLQRLKR THLLPDPEDE EAVRWLARAA HIRPDGRNDA AGVLREELKK QNVRVSKLHT 

       490        500        510        520        530        540 
KLFYQPLLES IGPTGLEIAH GMTLEAAGRR LAALGYEGPQ TALKHMSALV NQSGRRGRVQ 

       550        560        570        580        590        600 
SVLLPRLLDW MSYAPDPDGG LLAYRRLSEA LATESWYLAT LRDKPAVAKR LMHVLGTSAY 

       610        620        630        640        650        660 
VPDLLMRAPR VIQQYEDGPA GPKLLETEPA AVARALIASA SRYPDPERAI AGARTLRRRE 

       670        680        690        700        710        720 
LARIGSADLL GLLEVTEVCR ALTSVWVAVL QAALDVMIRA SLPDDDRAPA AIAVIGMGRL 

       730        740        750        760        770        780 
GGAELGYGSD ADVMFVCEPA TGVDDARAVK WSTSIAERVR ALLGTPSVDP PLELDANLRP 

       790        800        810        820        830        840 
EGRNGPLVRT LGSYAAYYEQ WAQPWEIQAL LRAHAVAGDA ELGQRFLRMV DKTRYPPDGV 

       850        860        870        880        890        900 
SADSVREIRR IKARIESERL PRGADPNTHT KLGRGGLADI EWTVQLLQLQ HAHQVPALHN 

       910        920        930        940        950        960 
TSTLQSLDVI AAADLVPAAD VELLRQAWLT ATRARNALVL VRGKPTDQLP GPGRQLNAVA 

       970        980        990 
VAAGWRNDDG GEFLDNYLRV TRRAKAVVRK VFGS 

P69942 in FASTA format

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