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[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
STRAIN=156 / Serotype M18, and 300 / Serotype M18;
DOI=10.1006/mpat.1993.1083; PubMed=7516997 [NCBI, ExPASy, EBI, Israel, Japan]
Kapur V.,
Topouzis S.,
Majesky M.W.,
Li L.L.,
Hamrick M.R.,
Hamill R.J.,
Patti J.M.,
Musser J.M.;
"A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin.";
Microb. Pathog. 15:327-346(1993).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MGAS8232 / Serotype M18;
DOI=10.1073/pnas.062526099; PubMed=11917108 [NCBI, ExPASy, EBI, Israel, Japan]
Smoot J.C.,
Barbian K.D.,
Van Gompel J.J.,
Smoot L.M.,
Chaussee M.S.,
Sylva G.L.,
Sturdevant D.E.,
Ricklefs S.M.,
Porcella S.F.,
Parkins L.D.,
Beres S.B.,
Campbell D.S.,
Smith T.M.,
Zhang Q.,
Kapur V.,
Daly J.A.,
Veasy L.G.,
Musser J.M.;
"Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks.";
Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002).
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- FUNCTION: Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.
- CATALYTIC ACTIVITY: Preferential cleavage with hydrophobic residues at P2, P1 and P1'.
- SUBCELLULAR LOCATION: Secreted.
- SIMILARITY: Belongs to the peptidase C10 family [view classification].
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 398 AA [This is the length of the unprocessed precursor] |
Molecular weight: 43174 Da [This is the MW of the unprocessed precursor] |
CRC64: 16FF180D720AEE0F [This is a checksum on the sequence] |
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10 20 30 40 50 60
MNKKKLGIRL LSLLALGGFV LANPVFADQN FARNEKEAKD SAITFIQKSA AIKAGARSAE
70 80 90 100 110 120
DIKLDKVNLG GELSGSNMYV YNISTGGFVI VSGDKRSPEI LGYSTSGSFD ANGKENIASF
130 140 150 160 170 180
MESYVEQIKE NKKLDTTYAG TAEIKQPVVK SLLDSKGIHY NQGNPYNLLT PVIEKVKPGE
190 200 210 220 230 240
QSFVGQHAAT GCVATATAQI MKYHNYPNKG LKDYTYTLSS NNPYFNHPKN LFAAISTRQY
250 260 270 280 290 300
NWNNILPTYS GRESNVQKMA ISELMADVGI SVDMDYGPSS GSAGSSRVQR ALKENFGYNQ
310 320 330 340 350 360
SVHQINRSDF SKQDWEAQID KELSQNQPVY YQGVGKVGGH AFVIDGADGR NFYHVNWGWG
370 380 390
GVSDGFFRLD ALNPSALGTG GGAGGFNGYQ SAVVGIKP
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P68885 in FASTA format |
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