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UniProtKB/Swiss-Prot entry P68106


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FKB1B_HUMAN
Primary accession number P68106
Secondary accession numbers Q13664 Q16645 Q53TM2 Q9BQ40
Integrated into Swiss-Prot on October 25, 2004
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 53)
Name and origin of the protein
Protein name Peptidyl-prolyl cis-trans isomerase FKBP1B
Synonyms PPIase FKBP1B
EC 5.2.1.8
FK506-binding protein 1B
FKBP-1B
Rotamase
Immunophilin FKBP12.6
12.6 kDa FKBP
FKBP-12.6
h-FKBP-12
Gene name
Name: FKBP1B
Synonyms: FKBP12.6, FKBP1L, FKBP9, OTK4
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
TISSUE=Fetal brain;
DOI=10.1006/bbrc.1994.1527; PubMed=7513996 [NCBI, ExPASy, EBI, Israel, Japan]
Arakawa H., Nagase H., Hayashi N., Fujiwara T., Ogawa M., Shin S., Nakamura Y.;
"Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts.";
Biochem. Biophys. Res. Commun. 200:836-843(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Brain, and Heart muscle;
DOI=10.1074/jbc.270.44.26511; PubMed=7592869 [NCBI, ExPASy, EBI, Israel, Japan]
Lam E., Martin M.M., Timerman A.P., Sabers C., Fleischer S., Lukas T., Abraham R.T., O'Keefe S.J., O'Neill E.A., Wiederrecht G.J.;
"A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor.";
J. Biol. Chem. 270:26511-26522(1995).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Seidler T., Kussebi N., Prestle J.;
"FKBP9: an alternative splice variant of the FK506-binding protein FKBP12.6 expressed in the human heart.";
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/j.gene.2005.07.004; PubMed=16122887 [NCBI, ExPASy, EBI, Israel, Japan]
Nakazawa T., Takasawa S., Noguchi N., Nata K., Tohgo A., Mori M., Nakagawara K., Akiyama T., Ikeda T., Yamauchi A., Takahashi I., Yoshikawa T., Okamoto H.;
"Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6.";
Gene 360:55-64(2005).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
DOI=10.1107/S0907444999016571; PubMed=10713512 [NCBI, ExPASy, EBI, Israel, Japan]
Deivanayagam C.C., Carson M., Thotakura A., Narayana S.V., Chodavarapu R.S.;
"Structure of FKBP12.6 in complex with rapamycin.";
Acta Crystallogr. D 56:266-271(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
S69815; AAB30684.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D38037; BAA07232.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L37086; AAC37581.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S69800; AAB30685.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF322070; AAK11191.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB190793; BAE44300.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC008073; AAY14663.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH471053; EAX00769.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC002614; AAH02614.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00073704; -.
IPI00396151; -.
PIR JC2188; JC2188.
RefSeq NP_004107.1; -.
NP_473374.1; -.
UniGene Hs.709461
3D structure databases
PDB
1C9H; X-ray; 2.00 A; A=2-108.[ExPASy / RCSB / EBI]
PDBsum 1C9H; -.
ModBase P68106.
Enzyme and pathway databases
BRENDA 5.2.1.8; 247.
Organism-specific databases
GeneCards GC02P024184; -.
H-InvDB HIX0001871; -.
HGNC HGNC:3712; FKBP1B.
GenAtlas FKBP1B.
MIM 600620; gene. [NCBI / EBI]
PharmGKB PA28154; -.
Gene expression databases
ArrayExpress P68106; -.
Bgee P68106; -.
CleanEx HS_FKBP1B; -.
HS_FKBP9; -.
GermOnline ENSG00000119782; Homo sapiens.
Ontologies
GO
GO:0034704; Cellular component: calcium channel complex (inferred from direct assay from UniProtKB).
GO:0005829; Cellular component: cytosol (inferred by curator from UniProtKB).
GO:0005528; Molecular function: FK506 binding (inferred from direct assay from UniProtKB).
GO:0003755; Molecular function: peptidyl-prolyl cis-trans isomerase activity (inferred from direct assay from UniProtKB).
GO:0005102; Molecular function: receptor binding (inferred from physical interaction from UniProtKB).
GO:0006458; Biological process: 'de novo' protein folding (traceable author statement from UniProtKB).
GO:0006936; Biological process: muscle contraction (non-traceable author statement from UniProtKB).
GO:0010459; Biological process: negative regulation of heart rate (inferred from sequence or structural similarity from UniProtKB).
GO:0032513; Biological process: negative regulation of protein phosphatase type 2B activity (inferred from direct assay from UniProtKB).
GO:0022417; Biological process: protein maturation by protein folding (traceable author statement from UniProtKB).
GO:0042026; Biological process: protein refolding (traceable author statement from UniProtKB).
GO:0010881; Biological process: regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (inferred from sequence or structural similarity from UniProtKB).
GO:0060314; Biological process: regulation of ryanodine-sensitive calcium-release channel activity (inferred from mutant phenotype from UniProtKB).
GO:0051775; Biological process: response to redox state (inferred from direct assay from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001179; PPIase_FKBP.
Graphical view of domain structure.
PANTHER PTHR10516; PPIase_FKBP; 1.
Pfam PF00254; FKBP_C; 1.
Pfam graphical view of domain structure.
PROSITE PS50059; FKBP_PPIASE; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE P68106; -.
Genome annotation databases
Ensembl ENSG00000119782; Homo sapiens. [Contig view]
GeneID 2281; -.
KEGG hsa:2281; -.
Phylogenomic databases
HOGENOM P68106; -.
HOVERGEN P68106; -.
OMA P68106; MNDELQI.
Other
NextBio 9275; -.
SOURCE FKBP1B; Homo sapiens.
ProtoNet P68106.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Alternative splicing; Cytoplasm; Isomerase; Rotamase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   108  107     Peptidyl-prolyl cis-trans isomerase FKBP1B. PRO_0000075295
DOMAIN   20   108  89     PPIase FKBP-type. 
VAR_SEQ   67   108        MSLGQRAKLTCTPDVAYGATGHPGVIPPNATLIFDVE LLNLE -> LGPLSPLPICPHPC (in isoform 2). VSP_005184
STRAND   3     9  7      
STRAND   22    31  10      
STRAND   36    39  4      
TURN   40    44  5      
STRAND   47    50  4      
TURN   51    54  4      
HELIX   58    65  8      
STRAND   72    77  6      
HELIX   79    81  3      
TURN   82    86  5      
TURN   89    91  3      
Sequence information
Length: 108 AA [This is the length of the unprocessed precursor] Molecular weight: 11783 Da [This is the MW of the unprocessed precursor] CRC64: BAC2A25945F63AC4 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGVEIETISP GDGRTFPKKG QTCVVHYTGM LQNGKKFDSS RDRNKPFKFR IGKQEVIKGF 

        70         80         90        100 
EEGAAQMSLG QRAKLTCTPD VAYGATGHPG VIPPNATLIF DVELLNLE 

P68106 in FASTA format

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