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UniProtKB/Swiss-Prot entry P68037


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name UB2L3_MOUSE
Primary accession number P68037
Secondary accession numbers P51966 P70653 Q9HAV1
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on October 11, 2004 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 40)
Name and origin of the protein
Protein name Ubiquitin-conjugating enzyme E2 L3
Synonyms EC 6.3.2.19
Ubiquitin-protein ligase L3
Ubiquitin carrier protein L3
UbcM4
Gene name
Name: Ube2l3
Synonyms: Ubce7
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/c;
TISSUE=Brain;
DOI=10.1073/pnas.93.22.12412; PubMed=8901595 [NCBI, ExPASy, EBI, Israel, Japan]
Harbers K., Mueller U., Grams A., Li E., Jaenisch R., Franz T.;
"Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality.";
Proc. Natl. Acad. Sci. U.S.A. 93:12412-12417(1996).
[2]
NUCLEOTIDE SEQUENCE.
Moynihan T.P., Nuber U., Ardley H.C., Markham A.F., Scheffner M., Robinson P.A.;
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Testis;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
S81004; AAB36018.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X97042; CAA65755.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ130961; CAA10265.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK007265; BAB24925.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JC6163; JC6163.
RefSeq NP_033482.1; -.
XP_001475006.1; -.
UniGene Mm.3074
3D structure databases
ModBase P68037.
Organism-specific databases
MGI MGI:109240; Ube2l3.
Gene expression databases
ArrayExpress P68037; -.
CleanEx MM_UBE2L3; -.
GermOnline ENSMUSG00000038965; Mus musculus.
Family and domain databases
InterPro IPR016135; UBQ-conjugat/RWD-like.
IPR000608; UBQ-conjugat_E2.
Graphical view of domain structure.
Gene3D G3DSA:3.10.110.10; UBQ-conjugat_E2; 1.
PANTHER PTHR11621; UBQ-conjugat_E2; 1.
Pfam PF00179; UQ_con; 1.
Pfam graphical view of domain structure.
ProDom PD000461; UBQ_conjugat; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00212; UBCc; 1.
SMART graphical view of domain structure.
PROSITE PS00183; UBIQUITIN_CONJUGAT_1; 1.
PS50127; UBIQUITIN_CONJUGAT_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P68037.
Genome annotation databases
Ensembl ENSMUSG00000038965; Mus musculus. [Contig view]
GeneID 100045890; -.
22195; -.
KEGG mmu:100045890; -.
mmu:22195; -.
Phylogenomic databases
HOGENOM P68037; -.
HOVERGEN P68037; -.
Other
SOURCE Ube2l3; Mus musculus.
ProtoNet P68037.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Ligase; Ubl conjugation pathway.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   154  154     Ubiquitin-conjugating enzyme E2 L3. PRO_0000082477
ACT_SITE   86    86        Glycyl thioester intermediate (By similarity). 
CONFLICT   102   102        D -> V (in Ref. 1; AAB36018). 
Sequence information
Length: 154 AA [This is the length of the unprocessed precursor] Molecular weight: 17862 Da [This is the MW of the unprocessed precursor] CRC64: F5A30243BE3C9985 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA FRIEINFPAE 

        70         80         90        100        110        120 
YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK TDQVIQSLIA LVNDPQPEHP 

       130        140        150 
LRADLAEEYS KDRKKFCKNA EEFTKKYGEK RPVD 

P68037 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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