ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P67733


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name COABC_MYCTU
Primary accession number P67733
Secondary accession number P71661
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on October 11, 2004 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 29)
Name and origin of the protein
Protein name Coenzyme A biosynthesis bifunctional protein coaBC
Synonym DNA/pantothenate metabolism flavoprotein
Includes Phosphopantothenoylcysteine decarboxylase
     (PPCDC)
     (EC 4.1.1.36)
     (CoaC)
Phosphopantothenate--cysteine ligase
     (EC 6.3.2.5)
     (Phosphopantothenoylcysteine synthase)
     (PPC synthetase)
     (PPCS)
     (CoaB)
Gene name
Name: coaBC
Synonyms: dfp
OrderedLocusNames: Rv1391, MT1436
ORFNames: MTCY21B4.08
From
Mycobacterium tuberculosis [TaxID: 1773] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
DOI=10.1038/31159; PubMed=9634230 [NCBI, ExPASy, EBI, Israel, Japan]
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.";
Nature 393:537-544(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CDC 1551 / Oshkosh;
DOI=10.1128/JB.184.19.5479-5490.2002; PubMed=12218036 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.";
J. Bacteriol. 184:5479-5490(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX842576; CAB02174.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE000516; AAK45701.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E70899; E70899.
RefSeq NP_215907.1; -.
NP_335887.1; -.
3D structure databases
HSSP Q9SWE5; 1MVN. [HSSP ENTRY / PDB]
ModBase P67733.
Organism-specific databases
TubercuList Rv1391; -.
Ontologies
GO
GO:0004632; Molecular function: phosphopantothenate--cysteine ligase activity (inferred from electronic annotation from EC).
GO:0004633; Molecular function: phosphopantothenoylcysteine decarboxylase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR005252; COABC.
IPR007085; DNA/pantothenate-metab_flavo_C.
IPR003382; Flavoprotein.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.10300; DNA/pantothenate-metab_flavo_C; 1.
G3DSA:3.40.50.1950; Flavoprotein; 1.
Pfam PF04127; DFP; 1.
PF02441; Flavoprotein; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00521; coaBC_dfp; 1.
BLOCKS P67733.
ProtoNet P67733.
Genome annotation databases
GeneID 886749; -.
924547; -.
GenomeReviews AE000516_GR; MT1436.
AL123456_GR; Rv1391.
KEGG mtc:MT1436; -.
mtu:Rv1391; -.
TIGR MT1436; -.
Phylogenomic databases
HOGENOM P67733; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Decarboxylase; Flavoprotein; FMN; Ligase; Lyase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   418  418     Coenzyme A biosynthesis bifunctional protein coaBC. PRO_0000232694
REGION   1   193  193     Phosphopantothenoylcysteine decarboxylase. 
REGION   194   418  225     Phosphopantothenate--cysteine ligase. 
BINDING   285   285        CTP (By similarity). 
BINDING   295   295        CTP (By similarity). 
BINDING   354   354        CTP (By similarity). 
BINDING   358   358        CTP (By similarity). 
Sequence information
Length: 418 AA [This is the length of the unprocessed precursor] Molecular weight: 43577 Da [This is the MW of the unprocessed precursor] CRC64: 48BD95E536595506 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVDHKRIPKQ VIVGVSGGIA AYKACTVVRQ LTEASHRVRV IPTESALRFV GAATFEALSG 

        70         80         90        100        110        120 
EPVCTDVFAD VPAVPHVHLG QQADLVVVAP ATADLLARAA AGRADDLLTA TLLTARCPVL 

       130        140        150        160        170        180 
FAPAMHTEMW LHPATVDNVA TLRRRGAVVL EPATGRLTGA DSGAGRLPEA EEITTLAQLL 

       190        200        210        220        230        240 
LERHDALPYD LAGRKLLVTA GGTREPIDPV RFIGNRSSGK QGYAVARVAA QRGADVTLIA 

       250        260        270        280        290        300 
GHTAGLVDPA GVEVVHVSSA QQLADAVSKH APTADVLVMA AAVADFRPAQ VATAKIKKGV 

       310        320        330        340        350        360 
EGPPTIELLR NDDVLAGVVR ARAHGQLPNM RAIVGFAAET GDANGDVLFH ARAKLRRKGC 

       370        380        390        400        410 
DLLVVNAVGE GRAFEVDSND GWLLASDGTE SALQHGSKTL MASRIVDAIV TFLAGCSS 

P67733 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!