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UniProtKB/Swiss-Prot entry P67042


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TYSY_BRUME
Primary accession number P67042
Secondary accession number Q8YI37
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on October 11, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 26)
Name and origin of the protein
Protein name Thymidylate synthase
Synonyms TS
TSase
EC 2.1.1.45
Gene name
Name: thyA
OrderedLocusNames: BMEI0608
From
Brucella melitensis [TaxID: 29459] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; Brucella.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=16M / ATCC 23456 / NCTC 10094 / Biotype 1;
DOI=10.1073/pnas.221575398; PubMed=11756688 [NCBI, ExPASy, EBI, Israel, Japan]
DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R.;
"The genome sequence of the facultative intracellular pathogen Brucella melitensis.";
Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE009503; AAL51789.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR AB3328; AB3328.
RefSeq NP_539525.1; -.
3D structure databases
HSSP P00470; 1TYS. [HSSP ENTRY / PDB]
ModBase P67042.
Enzyme and pathway databases
BioCyc BMEL224914:BMEI0608-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004799; Molecular function: thymidylate synthase activity (inferred from electronic annotation from HAMAP).
GO:0006231; Biological process: dTMP biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00008; -; 1.
PBIL [Tree]
InterPro IPR000398; Thymidylat_synth_C.
Graphical view of domain structure.
Gene3D G3DSA:3.30.572.10; Thymidylat_synth_C; 1.
PANTHER PTHR11549:SF2; Thymidylat_synth_C; 1.
Pfam PF00303; Thymidylat_synt; 1.
Pfam graphical view of domain structure.
PRINTS PR00108; THYMDSNTHASE.
ProDom PD001180; Thymidylat_synth; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR03284; thym_sym; 1.
PROSITE PS00091; THYMIDYLATE_SYNTHASE; 1.
ProtoNet P67042.
Genome annotation databases
GeneID 1196319; -.
GenomeReviews AE008917_GR; BMEI0608.
KEGG bme:BMEI0608; -.
Phylogenomic databases
HOGENOM P67042; -.
Genome annotation databases
CMR P67042; BMEI0608.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Methyltransferase; Nucleotide biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   264  264     Thymidylate synthase. PRO_0000140942
ACT_SITE   146   146        By similarity. 
Sequence information
Length: 264 AA [This is the length of the unprocessed precursor] Molecular weight: 30330 Da [This is the MW of the unprocessed precursor] CRC64: FECAD558B5EDCAFA [This is a checksum on the sequence]
        10         20         30         40         50         60 
MRTYLDLLQH VLDHGVDRDD RTGTGTRSVF GYQMRFDLEE GFPVLTTKKL HLRSIIHELL 

        70         80         90        100        110        120 
WFLKGDTNIA YLKENGVTIW DEWADENGDL GPVYGYQWRS WPAPDGRHID QIANLLKMLH 

       130        140        150        160        170        180 
TNPQSRRLIV SAWNPALVDE MALPPCHCLF QFYVANGRLS CQLYQRSADI FLGVPFNIAS 

       190        200        210        220        230        240 
YALLTMMIAQ VTGLKPGEFI HTLGDAHIYS NHFEQARLQL TRTPKKLPVM HINPDVKDLF 

       250        260 
AFRFEDFRLD GYEADPTIKA PIAV 

P67042 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
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