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UniProtKB/Swiss-Prot entry P65571


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NUOC_MYCTU
Primary accession number P65571
Secondary accession number P95179
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on October 11, 2004 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 22)
Name and origin of the protein
Protein name NADH-quinone oxidoreductase subunit C
Synonyms EC 1.6.99.5
NADH dehydrogenase I subunit C
NDH-1 subunit C
Gene name
Name: nuoC
OrderedLocusNames: Rv3147, MT3235
ORFNames: MTCY03A2.11c
From
Mycobacterium tuberculosis [TaxID: 1773] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
DOI=10.1038/31159; PubMed=9634230 [NCBI, ExPASy, EBI, Israel, Japan]
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.";
Nature 393:537-544(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CDC 1551 / Oshkosh;
DOI=10.1128/JB.184.19.5479-5490.2002; PubMed=12218036 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.";
J. Bacteriol. 184:5479-5490(2002).
Comments
  • FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
  • CATALYTIC ACTIVITY: NADH + quinone = NAD+ + quinol.
  • SIMILARITY: Belongs to the complex I 30 kDa subunit family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX842582; CAB06269.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE000516; AAK47574.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D70647; D70647.
RefSeq NP_217663.1; -.
NP_337760.1; -.
3D structure databases
ModBase P65571.
Organism-specific databases
TubercuList Rv3147; -.
Ontologies
GO
GO:0008137; Molecular function: NADH dehydrogenase (ubiquinone) activity (inferred from electronic annotation from InterPro).
GO:0048038; Molecular function: quinone binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006120; Biological process: mitochondrial electron transport, NADH to ubiquinone (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR010218; NADH_DH_csu.
IPR001268; NADH_DHase_Ub_30kDa_su.
Graphical view of domain structure.
Pfam PF00329; Complex1_30kDa; 1.
Pfam graphical view of domain structure.
ProDom PD001581; Complex1_30K; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01961; NuoC_fam; 1.
PROSITE PS00542; COMPLEX1_30K; FALSE_NEG.
ProtoNet P65571.
Genome annotation databases
GeneID 888816; -.
923382; -.
GenomeReviews AE000516_GR; MT3235.
AL123456_GR; Rv3147.
KEGG mtc:MT3235; -.
mtu:Rv3147; -.
TIGR MT3235; -.
Phylogenomic databases
HOGENOM P65571; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase; Quinone.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   236  236     NADH-quinone oxidoreductase subunit C. PRO_0000118670
Sequence information
Length: 236 AA [This is the length of the unprocessed precursor] Molecular weight: 26932 Da [This is the MW of the unprocessed precursor] CRC64: 251014470CA32BA6 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSPPNQDAQE GRPDSPTAEV VDVRRGMFGV SGTGDTSGYG RLVRQVVLPG SSPRPYGGYF 

        70         80         90        100        110        120 
DDIVDRLAEA LRHERVEFED AVEKVVVYRD ELTLHVRRDL LPRVAQRLRD EPELRFELCL 

       130        140        150        160        170        180 
GVSGVHYPHE TGRELHAVYP LQSITHNRRL RLEVSAPDSD PHIPSLFAIY PTNDWHERET 

       190        200        210        220        230 
YDFFGIIFDG HPALTRIEMP DDWQGHPQRK DYPLGGIPVE YKGAQIPPPD ERRGYN 

P65571 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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