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UniProtKB/Swiss-Prot entry P62979


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name RS27A_HUMAN
Primary accession number P62979
Secondary accession numbers P14798 Q6LBL4 Q9BQ77
Integrated into Swiss-Prot on August 31, 2004
Sequence was last modified on August 31, 2004 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 49)
Name and origin of the protein
Protein name 40S ribosomal protein S27a
Synonyms None
Gene name
Name: RPS27A
Synonyms: UBA80, UBCEP1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2581967 [NCBI, ExPASy, EBI, Israel, Japan]
Lund P.K., Moats-Staats B.M., Simmons J.G., Hoyt E., D'Ercole A.J., Martin F., van Wyk J.J.;
"Nucleotide sequence analysis of a cDNA encoding human ubiquitin reveals that ubiquitin is synthesized as a precursor.";
J. Biol. Chem. 260:7609-7613(1985).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1002/eji.1830211113; PubMed=1657614 [NCBI, ExPASy, EBI, Israel, Japan]
Pancre V., Pierce R.J., Fournier F., Mehtali M., Delanoye A., Capron A., Auriault C.;
"Effect of ubiquitin on platelet functions: possible identity with platelet activity suppressive lymphokine (PASL).";
Eur. J. Immunol. 21:2735-2741(1991).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1370760 [NCBI, ExPASy, EBI, Israel, Japan]
Adams S.M., Sharp M.G., Walker R.A., Brammar W.J., Varley J.M.;
"Differential expression of translation-associated genes in benign and malignant human breast tumours.";
Br. J. Cancer 65:65-71(1992).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta, and Urinary bladder;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PROTEIN SEQUENCE OF 1-22.
TISSUE=Placenta;
DOI=10.1111/j.1432-1033.1996.0144u.x; PubMed=8706699 [NCBI, ExPASy, EBI, Israel, Japan]
Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.;
"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.";
Eur. J. Biochem. 239:144-149(1996).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-72.
PubMed=9582194 [NCBI, ExPASy, EBI, Israel, Japan]
Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C.;
"A map of 75 human ribosomal protein genes.";
Genome Res. 8:509-523(1998).
[8]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M10939; AAA36788.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X63237; CAA44911.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S79522; AAB21188.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC012358; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
BC001392; AAH01392.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC066293; AAH66293.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB007163; BAA25826.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00179330; -.
UniGene Hs.311640
3D structure databases
ModBase P62979.
Protein-protein interaction databases
IntAct P62979; 7.
Enzyme and pathway databases
Reactome REACT_1762; 3' -UTR-mediated translational regulation.
REACT_6167; Influenza Infection.
REACT_71; Gene Expression.
Organism-specific databases
GeneCards GC01P190932; -.
GC02P055313; -.
GC06P114010; -.
H-InvDB HIX0002061; -.
HGNC HGNC:10417; RPS27A.
GenAtlas RPS27A.
MIM 191343; gene. [NCBI / EBI]
PharmGKB PA34821; -.
Gene expression databases
Bgee P62979; -.
CleanEx HS_RPS27A; -.
GermOnline ENSG00000143947; Homo sapiens.
Ontologies
GO
GO:0022627; Cellular component: cytosolic small ribosomal subunit (inferred from direct assay from UniProtKB).
GO:0003735; Molecular function: structural constituent of ribosome (inferred from direct assay from UniProtKB).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006414; Biological process: translational elongation (inferred from experiment from Reactome).
QuickGo view.
Family and domain databases
InterPro IPR002906; Ribosomal_S27a.
Graphical view of domain structure.
Pfam PF01599; Ribosomal_S27; 1.
Pfam graphical view of domain structure.
Proteomic databases
PRIDE P62979; -.
Genome annotation databases
Ensembl ENSG00000143947; Homo sapiens. [Contig view]
Phylogenomic databases
HOVERGEN P62979; -.
Other
SOURCE RPS27A; Homo sapiens.
ProtoNet P62979.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Metal-binding; Ribonucleoprotein; Ribosomal protein; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
CHAIN   1   80  80     40S ribosomal protein S27a. PRO_0000137662
ZN_FING   45   68  24     C4-type. 
COMPBIAS   1   23  23     Lys-rich (highly basic). 
Sequence information
Length: 80 AA [This is the length of the unprocessed precursor] Molecular weight: 9418 Da [This is the MW of the unprocessed precursor] CRC64: 5233F54BB6F9DC1B [This is a checksum on the sequence]
        10         20         30         40         50         60 
AKKRKKKSYT TPKKNKHKRK KVKLAVLKYY KVDENGKISR LRRECPSDEC GAGVFMASHF 

        70         80 
DRHYCGKCCL TYCFNKPEDK 

P62979 in FASTA format

View entry in raw text format (no links)
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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