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UniProtKB/Swiss-Prot entry P62753


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name RS6_HUMAN
Primary accession number P62753
Secondary accession numbers P08227 P10660 Q4VBY7 Q8N6Z7
Integrated into Swiss-Prot on August 1, 1988
Sequence was last modified on August 1, 1988 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 58)
Name and origin of the protein
Protein name 40S ribosomal protein S6
Synonym Phosphoprotein NP33
Gene name
Name: RPS6
ORFNames: OK/SW-cl.2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0378-1119(88)90414-3; PubMed=2840355 [NCBI, ExPASy, EBI, Israel, Japan]
Lott J.B., Mackie G.A.;
"Isolation and characterization of cloned cDNAs that code for human ribosomal protein S6.";
Gene 65:31-39(1988).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3279029 [NCBI, ExPASy, EBI, Israel, Japan]
Heinze H., Arnold H.H., Fischer D., Kruppa J.;
"The primary structure of the human ribosomal protein S6 derived from a cloned cDNA.";
J. Biol. Chem. 263:4139-4144(1988).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1093/hmg/1.8.565; PubMed=1301164 [NCBI, ExPASy, EBI, Israel, Japan]
Antoine M., Fried M.;
"The organization of the intron-containing human S6 ribosomal protein (rpS6) gene and determination of its location at chromosome 9p21.";
Hum. Mol. Genet. 1:565-570(1992).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0378-1119(92)90149-J; PubMed=1446836 [NCBI, ExPASy, EBI, Israel, Japan]
Pata I., Hoth S., Kruppa J., Metspalu A.;
"The human ribosomal protein S6 gene: isolation, primary structure and location in chromosome 9.";
Gene 121:387-392(1992).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Colon adenocarcinoma;
Shichijo S., Itoh K.;
"Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients.";
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-221.
TISSUE=Colon, Muscle, Pancreas, Skin, and Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
PROTEIN SEQUENCE OF 1-15.
TISSUE=Placenta;
DOI=10.1111/j.1432-1033.1996.0144u.x; PubMed=8706699 [NCBI, ExPASy, EBI, Israel, Japan]
Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.;
"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.";
Eur. J. Biochem. 239:144-149(1996).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-235 AND SER-236, AND MASS SPECTROMETRY.
DOI=10.1021/pr050048h; PubMed=16083285 [NCBI, ExPASy, EBI, Israel, Japan]
Kim J.-E., Tannenbaum S.R., White F.M.;
"Global phosphoproteome of HT-29 human colon adenocarcinoma cells.";
J. Proteome Res. 4:1339-1346(2005).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-235; SER-236 AND SER-240, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
[10]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78; SER-235; SER-236; SER-240 AND SER-244, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0611217104; PubMed=17287340 [NCBI, ExPASy, EBI, Israel, Japan]
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.";
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236, AND MASS SPECTROMETRY.
DOI=10.2116/analsci.24.161; PubMed=18187866 [NCBI, ExPASy, EBI, Israel, Japan]
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Anal. Sci. 24:161-166(2008).
[12]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240, AND MASS SPECTROMETRY.
DOI=10.1016/j.molcel.2008.07.007; PubMed=18691976 [NCBI, ExPASy, EBI, Israel, Japan]
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
[13]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148; SER-235; SER-236; SER-240; SER-244 AND SER-247, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[14]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M20020; AAA60288.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
J03537; AAA60287.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X67309; CAA47719.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M77232; AAA60289.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB062123; BAB93455.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000524; AAH00524.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC009427; AAH09427.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC027620; AAH27620.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC071907; AAH71907.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC071908; AAH71908.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC094826; AAH94826.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00021840; -.
PIR JC1394; R3HU6.
RefSeq NP_001001.2; -.
UniGene Hs.408073
3D structure databases
ModBase P62753.
Protein-protein interaction databases
IntAct P62753; 10.
PTM databases
PhosphoSite P62753; -.
Enzyme and pathway databases
Pathway_Interaction_DB il2_pi3kpathway; IL2 signaling events mediated by PI3K.
mtor_4pathway; mTOR signaling pathway.
Reactome REACT_1762; 3' -UTR-mediated translational regulation.
REACT_498; Signaling by Insulin receptor.
REACT_6167; Influenza Infection.
REACT_71; Gene Expression.
Organism-specific databases
GeneCards GC09M019366; -.
H-InvDB HIX0007947; -.
HGNC HGNC:10429; RPS6.
GenAtlas RPS6.
HPA CAB004027; -.
MIM 180460; gene. [NCBI / EBI]
PharmGKB PA31025; -.
Gene expression databases
ArrayExpress P62753; -.
Bgee P62753; -.
CleanEx HS_RPS6; -.
GermOnline ENSG00000137154; Homo sapiens.
Ontologies
GO
GO:0022627; Cellular component: cytosolic small ribosomal subunit (inferred from direct assay from UniProtKB).
GO:0005730; Cellular component: nucleolus (inferred from direct assay from UniProtKB).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from UniProtKB).
GO:0003735; Molecular function: structural constituent of ribosome (inferred from electronic annotation from InterPro).
GO:0042593; Biological process: glucose homeostasis (inferred from sequence or structural similarity from UniProtKB).
GO:0043065; Biological process: positive regulation of apoptosis (inferred from direct assay from UniProtKB).
GO:0042274; Biological process: ribosomal small subunit biogenesis (inferred from mutant phenotype from UniProtKB).
GO:0006364; Biological process: rRNA processing (inferred from mutant phenotype from UniProtKB).
GO:0031929; Biological process: TOR signaling pathway (inferred from direct assay from UniProtKB).
GO:0006414; Biological process: translational elongation (inferred from experiment from Reactome).
QuickGo view.
Family and domain databases
InterPro IPR014401; Ribosomal_S6_euk.
IPR001377; Ribosomal_S6e.
IPR018282; Ribosomal_S6e_CS.
Graphical view of domain structure.
PANTHER PTHR11502; Ribosomal_S6E; 1.
Pfam PF01092; Ribosomal_S6e; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF002129; Ribosom_S6_euk; 1.
ProDom PD003460; Ribosomal_S6E; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00578; RIBOSOMAL_S6E; 1.
Proteomic databases
PRIDE P62753; -.
Genome annotation databases
Ensembl ENSG00000137154; Homo sapiens. [Contig view]
GeneID 6194; -.
KEGG hsa:6194; -.
Phylogenomic databases
HOGENOM P62753; -.
HOVERGEN P62753; -.
OMA P62753; PLGDEWK.
Other
NextBio 24053; -.
SOURCE RPS6; Homo sapiens.
ProtoNet P62753.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Phosphoprotein; Polymorphism; Ribonucleoprotein; Ribosomal protein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   249  249     40S ribosomal protein S6. PRO_0000137312
MOD_RES   78    78        Phosphoserine. 
MOD_RES   148   148        Phosphoserine. 
MOD_RES   235   235        Phosphoserine. 
MOD_RES   236   236        Phosphoserine. 
MOD_RES   240   240        Phosphoserine. 
MOD_RES   244   244        Phosphoserine. 
MOD_RES   246   246        Phosphoserine (By similarity). 
MOD_RES   247   247        Phosphoserine. 
VARIANT   221   221  1     K -> R (in dbSNP:rs17852447 [NCBI]). VAR_025314 
CONFLICT   23    23        K -> T (in Ref. 1; AAA60288). 
CONFLICT   144   144        L -> R (in Ref. 1; AAA60288). 
CONFLICT   155   156        QY -> EC (in Ref. 2; AAA60287). 
CONFLICT   168   168        K -> R (in Ref. 2; AAA60287). 
CONFLICT   196   196        K -> Q (in Ref. 1; AAA60288). 
CONFLICT   219   219        E -> Q (in Ref. 2; AAA60287). 
Sequence information
Length: 249 AA [This is the length of the unprocessed precursor] Molecular weight: 28681 Da [This is the MW of the unprocessed precursor] CRC64: A61E435884E636AE [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA LGEEWKGYVV RISGGNDKQG 

        70         80         90        100        110        120 
FPMKQGVLTH GRVRLLLSKG HSCYRPRRTG ERKRKSVRGC IVDANLSVLN LVIVKKGEKD 

       130        140        150        160        170        180 
IPGLTDTTVP RRLGPKRASR IRKLFNLSKE DDVRQYVVRK PLNKEGKKPR TKAPKIQRLV 

       190        200        210        220        230        240 
TPRVLQHKRR RIALKKQRTK KNKEEAAEYA KLLAKRMKEA KEKRQEQIAK RRRLSSLRAS 


TSKSESSQK 

P62753 in FASTA format

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