[1]	NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. DOI=10.1074/jbc.274.21.14685; PubMed=10329663 [NCBI, ExPASy, EBI, Israel, Japan] Lin H., Wing S.S.; "Identification of rabbit reticulocyte E217K as a UBC7 homologue and functional characterization of its core domain loop."; J. Biol. Chem. 274:14685-14691(1999).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Heart; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in degradation of muscle-specific proteins.
CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
PATHWAY: Protein modification; protein ubiquitination .
TISSUE SPECIFICITY: Widely expressed, with higher level in testis.
DEVELOPMENTAL STAGE: Induced from days 15 to 30.
SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF099093; AAC69605.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC086980; AAH86980.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_073181.1; -.

UniGene

Rn.163149

3D structure databases

HSSP

P34477; 1PZV. [HSSP ENTRY / PDB]

SMR

P62255; 5-165, 6-166.

ModBase

P62255.

Organism-specific databases

RGD

620392; Ube2g1.

Gene expression databases

ArrayExpress

P62255; -.

GermOnline

ENSRNOG00000010041; Rattus norvegicus.

Family and domain databases

InterPro

IPR016135; UBQ-conjugat/RWD-like.
IPR000608; UBQ-conjugat_E2.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.110.10; UBQ-conjugat_E2; 1.

PANTHER

PTHR11621; UBQ-conjugat_E2; 1.

Pfam

PF00179; UQ_con; 1.
Pfam graphical view of domain structure.

ProDom

PD000461; UBQ_conjugat; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00212; UBCc; 1.
SMART graphical view of domain structure.

PROSITE

PS00183; UBIQUITIN_CONJUGAT_1; 1.
PS50127; UBIQUITIN_CONJUGAT_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

P62255.

Genome annotation databases

Ensembl

ENSRNOG00000010041; Rattus norvegicus. [Contig view]

GeneID

64631; -.

KEGG

rno:64631; -.

Phylogenomic databases

HOVERGEN

P62255; -.

Other

ProtoNet

P62255.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Acetylation; Ligase; Ubl conjugation pathway.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed (By similarity).`
`CHAIN`	`2 170`	`169`	`Ubiquitin-conjugating enzyme E2 G1.`	`PRO_0000082482`
`ACT_SITE`	`90 90`		`Glycyl thioester intermediate (By similarity).`
`MOD_RES`	`2 2`		`N-acetylthreonine (By similarity).`

Sequence information

Length: 170 AA [This is the length of the unprocessed precursor]

Molecular weight: 19509 Da [This is the MW of the unprocessed precursor]

CRC64: 36B61766D995B332 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTELQSALLL RRQLAELNKN PVEGFSAGLI DDNDLYRWEV LIIGPPDTLY EGGVFKAHLT 

        70         80         90        100        110        120 
FPKDYPLRPP KMKFITEIWH PNVDKNGDVC ISILHEPGED KYGYEKPEER WLPIHTVETI 

       130        140        150        160        170 
MISVISMLAD PNGDSPANVD AAKEWREDRN GEFKRKVARC VRKSQETAFE

P62255 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools