[1]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1093/nar/15.4.1869; PubMed=3822842 [NCBI, ExPASy, EBI, Israel, Japan]
Yeramian P.,
Chardin P.,
Madaule P.,
Tavitian A.;
"Nucleotide sequence of human rho cDNA clone 12.";
Nucleic Acids Res. 15:1869-1869(1987).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Retina;
DOI=10.1006/exer.1994.1102; PubMed=7835413 [NCBI, ExPASy, EBI, Israel, Japan]
Fagan K.P.,
Oliveira L.,
Pittler S.J.;
"Sequence of rho small GTP-binding protein cDNAs from human retina and identification of novel 5' end cloning artifacts.";
Exp. Eye Res. 59:235-237(1994).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
Puhl H.L. III,
Ikeda S.R.,
Aronstam R.S.;
"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).";
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N.,
Chen X.,
Rolfs A.,
Halleck A.,
Hines L.,
Eisenstein S.,
Koundinya M.,
Raphael J.,
Moreira D.,
Kelley T.,
LaBaer J.,
Lin Y.,
Phelan M.,
Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Oesophageal carcinoma;
DOI=10.1186/1471-2164-8-399; PubMed=17974005 [NCBI, ExPASy, EBI, Israel, Japan]
Bechtel S.,
Rosenfelder H.,
Duda A.,
Schmidt C.P.,
Ernst U.,
Wellenreuther R.,
Mehrle A.,
Schuster C.,
Bahr A.,
Blocker H.,
Heubner D.,
Hoerlein A.,
Michel G.,
Wedler H.,
Kohrer K.,
Ottenwalder B.,
Poustka A.,
Wiemann S.,
Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain, and Colon;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[7]
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NUCLEOTIDE SEQUENCE [MRNA] OF 5-193.
TISSUE=Mammary cancer;
DOI=10.1016/0378-1119(94)90382-4; PubMed=8039707 [NCBI, ExPASy, EBI, Israel, Japan]
Moscow J.A.,
He R.,
Gudas J.M.,
Cowan K.H.;
"Utilization of multiple polyadenylation signals in the human RHOA protooncogene.";
Gene 144:229-236(1994).
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[8]
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PROTEIN SEQUENCE OF 28-39; 45-57; 78-86; 130-144; 146-162 AND 165-184, AND ADP-RIBOSYLATION AT ASN-41.
PubMed=1328215 [NCBI, ExPASy, EBI, Israel, Japan]
Nemoto Y.,
Namba T.,
Teru-uchi T.,
Ushikubi F.,
Morii N.,
Narumiya S.;
"A rho gene product in human blood platelets. I. Identification of the platelet substrate for botulinum C3 ADP-ribosyltransferase as rhoA protein.";
J. Biol. Chem. 267:20916-20920(1992).
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[9]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 137-193.
PubMed=1556108 [NCBI, ExPASy, EBI, Israel, Japan]
Moscow J.A.,
Morrow C.S.,
He R.,
Mullenbach G.T.,
Cowan K.H.;
"Structure and function of the 5'-flanking sequence of the human cytosolic selenium-dependent glutathione peroxidase gene (hgpx1).";
J. Biol. Chem. 267:5949-5958(1992).
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[10]
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INTERACTION WITH ROCK1.
PubMed=8617235 [NCBI, ExPASy, EBI, Israel, Japan]
Ishizaki T.,
Maekawa M.,
Fujisawa K.,
Okawa K.,
Iwamatsu A.,
Fujita A.,
Watanabe N.,
Saito Y.,
Kakizuka A.,
Morii N.,
Narumiya S.;
"The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.";
EMBO J. 15:1885-1893(1996).
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[11]
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INTERACTION WITH ROCK2.
PubMed=8641286 [NCBI, ExPASy, EBI, Israel, Japan]
Matsui T.,
Amano M.,
Yamamoto T.,
Chihara K.,
Nakafuku M.,
Ito M.,
Nakano T.,
Okawa K.,
Iwamatsu A.,
Kaibuchi K.;
"Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.";
EMBO J. 15:2208-2216(1996).
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[12]
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INTERACTION WITH ARHGEF2.
DOI=10.1074/jbc.273.52.34954; PubMed=9857026 [NCBI, ExPASy, EBI, Israel, Japan]
Ren Y.,
Li R.,
Zheng Y.,
Busch H.;
"Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases.";
J. Biol. Chem. 273:34954-34960(1998).
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[13]
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INTERACTION WITH HRSV PROTEIN F.
PubMed=10438814 [NCBI, ExPASy, EBI, Israel, Japan]
Pastey M.K.,
Crowe J.E. Jr.,
Graham B.S.;
"RhoA interacts with the fusion glycoprotein of respiratory syncytial virus and facilitates virus-induced syncytium formation.";
J. Virol. 73:7262-7270(1999).
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[14]
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INTERACTION WITH RTKN.
DOI=10.1074/jbc.M000465200; PubMed=10940294 [NCBI, ExPASy, EBI, Israel, Japan]
Reynaud C.,
Fabre S.,
Jalinot P.;
"The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element.";
J. Biol. Chem. 275:33962-33968(2000).
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[15]
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INTERACTION WITH AKAP13.
DOI=10.1016/S0014-5793(01)02995-7; PubMed=11696353 [NCBI, ExPASy, EBI, Israel, Japan]
Klussmann E.,
Edemir B.,
Pepperle B.,
Tamma G.,
Henn V.,
Klauschenz E.,
Hundsrucker C.,
Maric K.,
Rosenthal W.;
"Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling.";
FEBS Lett. 507:264-268(2001).
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[16]
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INTERACTION WITH ARHGEF3.
DOI=10.1074/jbc.M207401200; PubMed=12221096 [NCBI, ExPASy, EBI, Israel, Japan]
Arthur W.T.,
Ellerbroek S.M.,
Der C.J.,
Burridge K.,
Wennerberg K.;
"XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.";
J. Biol. Chem. 277:42964-42972(2002).
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[17]
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INTERACTION WITH YERSINIA PESTIS YOPT, AND CLEAVAGE.
DOI=10.1016/S0092-8674(02)00766-3; PubMed=12062101 [NCBI, ExPASy, EBI, Israel, Japan]
Shao F.,
Merritt P.M.,
Bao Z.,
Innes R.W.,
Dixon J.E.;
"A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis.";
Cell 109:575-588(2002).
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[18]
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FUNCTION, AND INTERACTION WITH PLCE1.
DOI=10.1074/jbc.M306904200; PubMed=12900402 [NCBI, ExPASy, EBI, Israel, Japan]
Wing M.R.,
Snyder J.T.,
Sondek J.,
Harden T.K.;
"Direct activation of phospholipase C-epsilon by Rho.";
J. Biol. Chem. 278:41253-41258(2003).
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[19]
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INTERACTION WITH YERSINIA PSEUDOTUBERCULOSIS YOPT, CLEAVAGE, AND MUTAGENESIS OF LEU-193.
DOI=10.1073/pnas.252770599; PubMed=12538863 [NCBI, ExPASy, EBI, Israel, Japan]
Shao F.,
Vacratsis P.O.,
Bao Z.,
Bowers K.E.,
Fierke C.A.,
Dixon J.E.;
"Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPases.";
Proc. Natl. Acad. Sci. U.S.A. 100:904-909(2003).
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[20]
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IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J.,
Superti-Furga G.,
Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
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[21]
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X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
DOI=10.1038/nsb0997-699; PubMed=9302995 [NCBI, ExPASy, EBI, Israel, Japan]
Wei Y.,
Zhang Y.,
Derewenda U.,
Liu X.,
Minor W.,
Nakamoto R.K.,
Somlyo A.V.,
Somlyo A.P.,
Derewenda Z.S.;
"Crystal structure of RhoA-GDP and its functional implications.";
Nat. Struct. Biol. 4:699-703(1997).
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[22]
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X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 4-181 OF MUTANT VAL-14.
DOI=10.1074/jbc.273.16.9656; PubMed=9545299 [NCBI, ExPASy, EBI, Israel, Japan]
Ihara K.,
Muraguchi S.,
Kato M.,
Shimizu T.,
Shirakawa M.,
Kuroda S.,
Kaibuchi K.,
Hakoshima T.;
"Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue.";
J. Biol. Chem. 273:9656-9666(1998).
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[23]
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X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1-181 IN COMPLEX WITH PRKCL1.
DOI=10.1006/jsbi.1999.4114; PubMed=10388627 [NCBI, ExPASy, EBI, Israel, Japan]
Maesaki R.,
Shimizu T.,
Ihara K.,
Kuroda S.,
Kaibuchi K.,
Hakoshima T.;
"Biochemical and crystallographic characterization of a Rho effector domain of the protein serine/threonine kinase N in a complex with RhoA.";
J. Struct. Biol. 126:166-170(1999).
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[24]
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X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 3-180 IN COMPLEX WITH GDP.
DOI=10.1074/jbc.M910274199; PubMed=10748207 [NCBI, ExPASy, EBI, Israel, Japan]
Shimizu T.,
Ihara K.,
Maesaki R.,
Kuroda S.,
Kaibuchi K.,
Hakoshima T.;
"An open conformation of switch I revealed by the crystal structure of a Mg2+-free form of RHOA complexed with GDP. Implications for the GDP/GTP exchange mechanism.";
J. Biol. Chem. 275:18311-18317(2000).
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[25]
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X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
DOI=10.1016/S1074-5521(02)00112-6; PubMed=11927263 [NCBI, ExPASy, EBI, Israel, Japan]
Graham D.L.,
Lowe P.N.,
Grime G.W.,
Marsh M.,
Rittinger K.,
Smerdon S.J.,
Gamblin S.J.,
Eccleston J.F.;
"MgF(3)(-) as a transition state analog of phosphoryl transfer.";
Chem. Biol. 9:375-381(2002).
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[26]
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X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) IN COMPLEX WITH MCF2.
DOI=10.1038/nsb796; PubMed=12006984 [NCBI, ExPASy, EBI, Israel, Japan]
Snyder J.T.,
Worthylake D.K.,
Rossman K.L.,
Betts L.,
Pruitt W.M.,
Siderovski D.P.,
Der C.J.,
Sondek J.;
"Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.";
Nat. Struct. Biol. 9:468-475(2002).
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[27]
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X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF MUTANT LEU-63 IN COMPLEX WITH A GTP ANALOG AND MG(2+).
DOI=10.1107/S0907444903005390; PubMed=12777804 [NCBI, ExPASy, EBI, Israel, Japan]
Longenecker K.,
Read P.,
Lin S.-K.,
Somlyo A.P.,
Nakamoto R.K.,
Derewenda Z.S.;
"Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution.";
Acta Crystallogr. D 59:876-880(2003).
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