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UniProtKB/Swiss-Prot entry P60604

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name UB2G2_HUMAN
Primary accession number P60604
Secondary accession number P56554
Integrated into Swiss-Prot on March 15, 2004
Sequence was last modified on March 15, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 56)
Name and origin of the protein
Protein name Ubiquitin-conjugating enzyme E2 G2
Synonyms EC 6.3.2.19
Ubiquitin-protein ligase G2
Ubiquitin carrier protein G2
Gene name
Name: UBE2G2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1006/geno.1998.5263; PubMed=9693041 [NCBI, ExPASy, EBI, Israel, Japan]
Katsanis N., Fisher E.M.C.;
"Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae UBC7 gene.";
Genomics 51:128-131(1998).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/35012518; PubMed=10830953 [NCBI, ExPASy, EBI, Israel, Japan]
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
"The DNA sequence of human chromosome 21.";
Nature 405:311-319(2000).
[4]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
 X-RAY CRYSTALLOGRAPHY (2.56 ANGSTROMS).
DOI=10.1107/S1744309106009006; PubMed=16582478 [NCBI, ExPASy, EBI, Israel, Japan]
Arai R., Yoshikawa S., Murayama K., Imai Y., Takahashi R., Shirouzu M., Yokoyama S.;
"Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7).";
Acta Crystallogr. F 62:330-334(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF032456; AAC32312.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT006914; AAP35560.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL163300; CAB90551.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC001738; AAH01738.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC008351; AAH08351.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC011569; AAH11569.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_003334.2; -.
NP_872630.1; -.
UniGene Hs.529420
3D structure databases
PDB
2CYX; X-ray; 2.56 A; A/B/C=1-165.[ExPASy / RCSB / EBI]
PDBsum 2CYX; -.
ModBase P60604.
Protein-protein interaction databases
IntAct P60604; -.
Organism-specific databases
H-InvDB HIX0016172; -.
HGNC HGNC:12483; UBE2G2.
GenAtlas UBE2G2.
HPA HPA003332; -.
MIM 603124; gene. [NCBI / EBI]
PharmGKB PA37132; -.
GeneCards P60604.
Gene expression databases
ArrayExpress P60604; -.
CleanEx HS_UBE2G2; -.
GermOnline ENSG00000184787; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from UniProtKB).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from UniProtKB).
GO:0006511; Biological process: ubiquitin-dependent protein catabolic process (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR016135; UBQ-conjugat/RWD-like.
IPR000608; UBQ-conjugat_E2.
Graphical view of domain structure.
Gene3D G3DSA:3.10.110.10; UBQ-conjugat_E2; 1.
PANTHER PTHR11621; UBQ-conjugat_E2; 1.
Pfam PF00179; UQ_con; 1.
Pfam graphical view of domain structure.
ProDom PD000461; UBQ_conjugat; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00212; UBCc; 1.
SMART graphical view of domain structure.
PROSITE PS00183; UBIQUITIN_CONJUGAT_1; 1.
PS50127; UBIQUITIN_CONJUGAT_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P60604.
Genome annotation databases
Ensembl ENSG00000184787; Homo sapiens. [Contig view]
GeneID 7327; -.
KEGG hsa:7327; -.
Phylogenomic databases
HOGENOM P60604; -.
HOVERGEN P60604; -.
Other
SOURCE UBE2G2; Homo sapiens.
ProtoNet P60604.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Ligase; Ubl conjugation pathway.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   165  165     Ubiquitin-conjugating enzyme E2 G2. PRO_0000082483
ACT_SITE   89    89        Glycyl thioester intermediate. 
CONFLICT   12    12        E -> V (in Ref. 1; AAC32312). 
CONFLICT   101   107        MGYESSA -> HGLREQP (in Ref. 1; AAC32312). 
HELIX   1    18  18      
STRAND   24    30  7      
STRAND   36    42  7      
TURN   48    51  4      
STRAND   53    59  7      
TURN   62    65  4      
STRAND   70    75  6      
STRAND   86    88  3      
HELIX   91    93  3      
HELIX   105   108  4      
HELIX   116   128  13      
HELIX   135   137  3      
HELIX   138   145  8      
HELIX   148   162  15      
Sequence information
Length: 165 AA [This is the length of the unprocessed precursor] Molecular weight: 18566 Da [This is the MW of the unprocessed precursor] CRC64: 74DEC732A79575E3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAGTALKRLM AEYKQLTLNP PEGIVAGPMN EENFFEWEAL IMGPEDTCFE FGVFPAILSF 

        70         80         90        100        110        120 
PLDYPLSPPK MRFTCEMFHP NIYPDGRVCI SILHAPGDDP MGYESSAERW SPVQSVEKIL 

       130        140        150        160 
LSVVSMLAEP NDESGANVDA SKMWRDDREQ FYKIAKQIVQ KSLGL
P60604 in FASTA format

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