[1]	NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND INTERACTION WITH BETA-TUBULIN. PubMed=10899939 [NCBI, ExPASy, EBI, Israel, Japan] Wang H., Olsen R.W.; "Binding of the GABA(A) receptor-associated protein (GABARAP) to microtubules and microfilaments suggests involvement of the cytoskeleton in GABARAPGABA(A) receptor interaction."; J. Neurochem. 75:644-655(2000).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Pituitary; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[3]	INTERACTION WITH GPHN. DOI=10.1073/pnas.97.15.8594; PubMed=10900017 [NCBI, ExPASy, EBI, Israel, Japan] Kneussel M., Haverkamp S., Fuhrmann J.C., Wang H., Waessle H., Olsen R.W., Betz H.; "The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse."; Proc. Natl. Acad. Sci. U.S.A. 97:8594-8599(2000).
[4]	FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INTERACTION WITH NSF. DOI=10.1006/mcne.2001.1005; PubMed=11461150 [NCBI, ExPASy, EBI, Israel, Japan] Kittler J.T., Rostaing P., Schiavo G., Fritschy J.-M., Olsen R., Triller A., Moss S.J.; "The subcellular distribution of GABARAP and its ability to interact with NSF suggest a role for this protein in the intracellular transport of GABA(A) receptors."; Mol. Cell. Neurosci. 18:13-25(2001).
[5]	X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS). DOI=10.1093/embo-reports/kvf026; PubMed=11818336 [NCBI, ExPASy, EBI, Israel, Japan] Bavro V.N., Sola M., Bracher A., Kneussel M., Betz H., Weissenhorn W.; "Crystal structure of the GABA(A)-receptor-associated protein, GABARAP."; EMBO Rep. 3:183-189(2002).

Comments

FUNCTION: May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton.
SUBUNIT: Interacts with GABRG2, TUBA1 and ULK1 (By similarity). Interacts with beta-tubulin, GPHN and NSF.
INTERACTION:
Q9QUL6:Nsf; NbExp=1; IntAct=EBI-925812, EBI-925794;
SUBCELLULAR LOCATION: Intracytoplasmic membrane. Cytoplasm, cytoskeleton. Golgi apparatus membrane. Note=Largely associated with intracellular membrane structures including the Golgi apparatus and post-synaptic cisternae. Colocalizes with microtubules.
TISSUE SPECIFICITY: Can be found in both somatodendritic and axonal compartment of neurons.
SIMILARITY: Belongs to the MAP1 LC3 family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF161588; AAD47643.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC058441; AAH58441.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_742033.1; -.

UniGene

Rn.8411

3D structure databases

PDB

1KJT; X-ray; 2.00 A; A=1-117.

[ExPASy / RCSB / EBI]

PDBsum

1KJT; -.

ModBase

P60517.

Protein-protein interaction databases

IntAct

P60517; -.

Organism-specific databases

RGD

61911; Gabarap.

Gene expression databases

ArrayExpress

P60517; -.

GermOnline

ENSRNOG00000017417; Rattus norvegicus.

Ontologies

GO:0005515;	Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.

Family and domain databases

InterPro

IPR004241; MAP1_LC3.
Graphical view of domain structure.

PANTHER

PTHR10969; MAP1_LC3; 1.

Pfam

PF02991; MAP1_LC3; 1.
Pfam graphical view of domain structure.

BLOCKS

P60517.

Genome annotation databases

Ensembl

ENSRNOG00000017417; Rattus norvegicus. [Contig view]

GeneID

58974; -.

KEGG

rno:58974; -.

Phylogenomic databases

HOVERGEN

P60517; -.

Other

P60517; -.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Cytoplasm; Cytoskeleton; Golgi apparatus; Membrane; Microtubule; Protein transport; Transport.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 117`	`117`	`Gamma-aminobutyric acid receptor-associated protein.`	`PRO_0000212366`
`REGION`	`1 22`	`22`	`Interaction with beta-tubulin.`
`REGION`	`36 117`	`82`	`Interaction with GPHN.`
`REGION`	`36 68`	`33`	`Interaction with GABRG2 (Potential).`
`HELIX`	`4 8`	`5`
`HELIX`	`11 24`	`14`
`STRAND`	`28 35`	`8`
`STRAND`	`48 52`	`5`
`HELIX`	`57 68`	`12`
`STRAND`	`77 82`	`6`
`HELIX`	`91 98`	`8`
`STRAND`	`105 112`	`8`

Sequence information

Length: 117 AA [This is the length of the unprocessed precursor]

Molecular weight: 13918 Da [This is the MW of the unprocessed precursor]

CRC64: BC0B84B8A51C1E32 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF 

        70         80         90        100        110 
YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGL

P60517 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools