Testis spermatocyte apoptosis-related gene 6 protein
Testis and spermatogenesis cell-related protein 6
Testis spermatogenesis apoptosis-related gene 6 protein
Testis spermatogenesis apoptosis-related gene 3 protein

Gene name

	Name:	DNAJB13
	Synonyms:	TSARG3, TSARG6

From

Homo sapiens (Human)

[TaxID: 9606]

Taxonomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Protein existence

2: Evidence at transcript level;

References

[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). TISSUE=Testis; Liu G., Lu G., Fu J., Liu S., Xing X., Li L.; "Molecular cloning of Homo sapiens testis spermatogenesis apoptosis related gene 5 (TSARG5)."; Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
[2]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). TISSUE=Testis; Liu G., Lu G., Fu J.; "Molecular cloning of Homo sapiens testis spermatogenesis apoptosis related gene 6 (TSARG6)."; Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
[3]	PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA] OF 112-316. TISSUE=Testis; PubMed=12673577 [NCBI, ExPASy, EBI, Israel, Japan] Liu G., Lu G.-X., Fu J.-J., Liu S.-F., Xing X.-W., Li L.; "Molecular cloning of TSARG3 gene related to apoptosis in human spermatogenic cells."; Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20:107-110(2003).

Comments

FUNCTION: May be involved in inhibiting testis spermatogenesis apoptosis.

ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.

Name	1
Isoform ID	P59910-1
This is the isoform sequence displayed in this entry.

Name	2
Synonyms	TSARG5
Isoform ID	P59910-2
Features which should be applied to build the isoform sequence: VSP_008519, VSP_008520.

TISSUE SPECIFICITY: Specifically expressed in testis.
SIMILARITY: Contains 1 J domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF516185; AAP47195.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY138810; AAN15929.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF419291; AAN32702.1; ALT_SEQ; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00374262; -.
IPI00374263; -.

RefSeq

NP_705842.2; -.

UniGene

Hs.567888

3D structure databases

ModBase

P59910.

Organism-specific databases

GC11P073340; -.

HGNC:30718; DNAJB13.

610263; gene. [NCBI / EBI]

PharmGKB

PA142671972; -.

Gene expression databases

P59910; -.

P59910; -.

HS_DNAJB13; -.

ENSG00000187726; Homo sapiens.

Ontologies

GO:0031072;	Molecular function: heat shock protein binding (inferred from electronic annotation from InterPro).
GO:0051082;	Molecular function: unfolded protein binding (inferred from electronic annotation from InterPro).
GO:0006915;	Biological process: apoptosis (inferred from expression pattern from UniProtKB).
GO:0006457;	Biological process: protein folding (inferred from electronic annotation from InterPro).
GO:0007283;	Biological process: spermatogenesis (inferred from expression pattern from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR002939; DnaJ_C.
IPR001623; DnaJ_N.
IPR018253; Heat_shock_DnaJ_CS.
IPR015609; Hsp40/DnaJ_Rel.
IPR003095; Hsp_DnaJ.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.287.110; DnaJ_N; 1.

PANTHER

PTHR11821; Hsp40/DnaJ_Rel; 1.

Pfam

PF00226; DnaJ; 1.
PF01556; DnaJ_C; 1.
Pfam graphical view of domain structure.

PRINTS

PR00625; DNAJPROTEIN.

SMART

SM00271; DnaJ; 1.
SMART graphical view of domain structure.

PROSITE

PS00636; DNAJ_1; 1.
PS50076; DNAJ_2; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

P59910; -.

Genome annotation databases

Ensembl

ENSG00000187726; Homo sapiens. [Contig view]

GeneID

374407; -.

KEGG

hsa:374407; -.

Phylogenomic databases

HOVERGEN

P59910; -.

OMA

P59910; LTIDVRP.

Other

NextBio

100185; -.

SOURCE

DNAJB13; Homo sapiens.

ProtoNet

P59910.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Chaperone.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 316`	`316`	`DnaJ homolog subfamily B member 13.`	`PRO_0000071039`
`DOMAIN`	`4 68`	`65`	`J.`
`VAR_SEQ`	`1 175`		`Missing (in isoform 2).`	`VSP_008519`
`VAR_SEQ`	`176 201`		`KDKILTIDVKPGWRQGTRITFEKEGD -> METSRGRNLAKVTRPTSPCHLLASPA (in isoform 2).`	`VSP_008520`

Sequence information

Length: 316 AA [This is the length of the unprocessed precursor]

Molecular weight: 36118 Da [This is the MW of the unprocessed precursor]

CRC64: 8251CB720724B7E5 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGQDYYSVLG ITRNSEDAQI KQAYRRLALK HHPLKSNEPS SAEIFRQIAE AYDVLSDPMK 

        70         80         90        100        110        120 
RGIYDKFGEE GLKGGIPLEF GSQTPWTTGY VFHGKPEKVF HEFFGGNNPF SEFFDAEGSE 

       130        140        150        160        170        180 
VDLNFGGLQG RGVKKQDPQV ERDLYLSLED LFFGCTKKIK ISRRVLNEDG YSSTIKDKIL 

       190        200        210        220        230        240 
TIDVKPGWRQ GTRITFEKEG DQGPNIIPAD IIFIVKEKLH PRFRRENDNL FFVNPIPLGK 

       250        260        270        280        290        300 
ALTCCTVEVR TLDDRLLNIP INDIIHPKYF KKVPGEGMPL PEDPTKKGDL FIFFDIQFPT 

       310 
RLTPQKKQML RQALLT

P59910 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools