[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1074/jbc.M203915200; PubMed=12019269 [NCBI, ExPASy, EBI, Israel, Japan] Wang L., Manji G.A., Grenier J.M., Al-Garawi A., Merriam S., Lora J.M., Geddes B.J., Briskin M., DiStefano P.S., Bertin J.; "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing."; J. Biol. Chem. 277:29874-29880(2002).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1038/nrm1019; PubMed=12563287 [NCBI, ExPASy, EBI, Israel, Japan] Tschopp J., Martinon F., Burns K.; "NALPs: a novel protein family involved in inflammation."; Nat. Rev. Mol. Cell Biol. 4:95-104(2003).
[3]	FUNCTION. DOI=10.1016/S0014-5793(02)03416-6; PubMed=12387869 [NCBI, ExPASy, EBI, Israel, Japan] Grenier J.M., Wang L., Manji G.A., Huang W.-J., Al-Garawi A., Kelly R., Carlson A., Merriam S., Lora J.M., Briskin M., DiStefano P.S., Bertin J.; "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1."; FEBS Lett. 530:73-78(2002).

Comments

FUNCTION: May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B.
SUBUNIT: Binds to ASC with its DAPIN domain.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Highly expressed in granulocytes. Detected at much lower levels in T-cells.
SIMILARITY: Belongs to the NLRP family.
SIMILARITY: Contains 1 DAPIN domain.
SIMILARITY: Contains 5 LRR (leucine-rich) repeats.
SIMILARITY: Contains 1 NACHT domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF479748; AAL87105.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154461; AAO18157.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00168279; -.

NP_612202.1; -.

3D structure databases

ModBase

P59044.

Organism-specific databases

GC11P000269; -.

HIX0035903; -.

HGNC:22944; NLRP6.

609650; gene. [NCBI / EBI]

Gene expression databases

P59044; -.

P59044; -.

HS_NLRP6; -.

ENSG00000174885; Homo sapiens.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005515;	Molecular function: protein binding (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR011029; DEATH-like.
IPR007111; NACHT_NTPase.
IPR004020; Pyrin.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.533.10; DEATH_like; 1.

Pfam

PF05729; NACHT; 1.
PF02758; PAAD_DAPIN; 1.
Pfam graphical view of domain structure.

PROSITE

PS50824; DAPIN; 1.
PS50837; NACHT; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

P59044; -.

Genome annotation databases

Ensembl

ENSG00000174885; Homo sapiens. [Contig view]

GeneID

171389; -.

KEGG

hsa:171389; -.

Phylogenomic databases

HOGENOM

P59044; -.

HOVERGEN

P59044; -.

Other

89223; -.

NLRP6; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Cytoplasm; Leucine-rich repeat; Nucleotide-binding; Repeat.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 892`	`892`	`NACHT, LRR and PYD domains-containing protein 6.`	`PRO_0000080892`
`DOMAIN`	`1 103`	`103`	`DAPIN.`
`DOMAIN`	`196 513`	`318`	`NACHT.`
`REPEAT`	`462 487`	`26`	`LRR 1.`
`REPEAT`	`727 747`	`21`	`LRR 2.`
`REPEAT`	`755 778`	`24`	`LRR 3.`
`REPEAT`	`811 834`	`24`	`LRR 4.`
`REPEAT`	`845 868`	`24`	`LRR 5.`
`NP_BIND`	`202 209`	`8`	`ATP (Potential).`
`COMPBIAS`	`604 614`	`11`	`Poly-Glu.`

Sequence information

Length: 892 AA [This is the length of the unprocessed precursor]

Molecular weight: 98734 Da [This is the MW of the unprocessed precursor]

CRC64: 4AA8D1FC766DDE9D [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDQPEAPCSS TGPRLAVARE LLLAALEELS QEQLKRFRHK LRDVGPDGRS IPWGRLERAD 

        70         80         90        100        110        120 
AVDLAEQLAQ FYGPEPALEV ARKTLKRADA RDVAAQLQER RLQRLGLGSG TLLSVSEYKK 

       130        140        150        160        170        180 
KYREHVLQLH ARVKERNARS VKITKRFTKL LIAPESAAPE EALGPAEEPE PGRARRSDTH 

       190        200        210        220        230        240 
TFNRLFRRDE EGRRPLTVVL QGPAGIGKTM AAKKILYDWA AGKLYQGQVD FAFFMPCGEL 

       250        260        270        280        290        300 
LERPGTRSLA DLILDQCPDR GAPVPQMLAQ PQRLLFILDG ADELPALGGP EAAPCTDPFE 

       310        320        330        340        350        360 
AASGARVLGG LLSKALLPTA LLLVTTRAAA PGRLQGRLCS PQCAEVRGFS DKDKKKYFYK 

       370        380        390        400        410        420 
FFRDERRAER AYRFVKENET LFALCFVPFV CWIVCTVLRQ QLELGRDLSR TSKTTTSVYL 

       430        440        450        460        470        480 
LFITSVLSSA PVADGPRLQG DLRNLCRLAR EGVLGRRAQF AEKELEQLEL RGSKVQTLFL 

       490        500        510        520        530        540 
SKKELPGVLE TEVTYQFIDQ SFQEFLAALS YLLEDGGVPR TAAGGVGTLL RGDAQPHSHL 

       550        560        570        580        590        600 
VLTTRFLFGL LSAERMRDIE RHFGCMVSER VKQEALRWVQ GQGQGCPGVA PEVTEGAKGL 

       610        620        630        640        650        660 
EDTEEPEEEE EGEEPNYPLE LLYCLYETQE DAFVRQALCR FPELALQRVR FCRMDVAVLS 

       670        680        690        700        710        720 
YCVRCCPAGQ ALRLISCRLV AAQEKKKKSL GKRLQASLGG GSSSQGTTKQ LPASLLHPLF 

       730        740        750        760        770        780 
QAMTDPLCHL SSLTLSHCKL PDAVCRDLSE ALRAAPALTE LGLLHNRLSE AGLRMLSEGL 

       790        800        810        820        830        840 
AWPQCRVQTV RVQLPDPQRG LQYLVGMLRQ SPALTTLDLS GCQLPAPMVT YLCAVLQHQG 

       850        860        870        880        890 
CGLQTLSLAS VELSEQSLQE LQAVKRAKPD LVITHPALDG HPQPPKELIS TF

P59044 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools