NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tokyo 1998;
DOI=10.1038/35024074; PubMed=10993077 [NCBI, ExPASy, EBI, Israel, Japan]
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS.";
Nature 407:81-86(2000).

Comments

CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6 .
SUBUNIT: Contains six catalytic and six regulatory chains (By similarity).
SIMILARITY: Belongs to the ATCase/OTCase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BA000003; BAB13073.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_240187.1; -.

3D structure databases

HSSP

P00479; 3CSU. [HSSP ENTRY / SWISS-3DIMAGE / PDB]

SMR

P57450; 3-305.

ModBase

P57450.

Enzyme and pathway databases

BioCyc

BSP107806:BU369-MON; -.

Ontologies

GO:0004070;	Molecular function: aspartate carbamoyltransferase activity (inferred from electronic annotation from HAMAP).
GO:0006221;	Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00001; -; 1.
PBIL [Tree]

InterPro

IPR006130; Asp/Orn_carbamoyltranf.
IPR006132; Asp/Orn_carbamoyltranf_P_bd.
IPR006131; Asp_carbamoyltransf_Asp/Orn_bd.
IPR002082; Aspartate_carbamoyltransf_euk.
Graphical view of domain structure.

Pfam

PF00185; OTCace; 1.
PF02729; OTCace_N; 1.
Pfam graphical view of domain structure.

PRINTS

PR00100; AOTCASE.
PR00101; ATCASE.

TIGRFAMs

TIGR00670; asp_carb_tr; 1.

PROSITE

PS00097; CARBAMOYLTRANSFERASE; 1.

BLOCKS

P57450.

Genome annotation databases

GeneID

1109723; -.

GenomeReviews

BA000003_GR; BU369.

KEGG

buc:BU369; -.

Phylogenomic databases

HOGENOM

P57450; -.

Genome annotation databases

CMR

P57450; BU369.

Other

ProtoNet

P57450.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Pyrimidine biosynthesis; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 310`	`310`		`Aspartate carbamoyltransferase catalytic chain.`	`PRO_0000113110`

Sequence information

Length: 310 AA [This is the length of the unprocessed precursor]

Molecular weight: 35553 Da [This is the MW of the unprocessed precursor]

CRC64: B02131513FA8D388 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MRNSLYKKNI ISINDLQRNE LELVLNKSAM LKKTPQPNLL KNKVIASCFF EASTRTRLSF 

        70         80         90        100        110        120 
ETAIYRLGAS IVGFSDGNNI SLEKKGETLT DTISVISSYV DAIIIRHPQE GSARLAAEFS 

       130        140        150        160        170        180 
NKKPIFNAGD GANQHPTQTL LDLFTIQETQ NRLTQLNIAI VGDLKYGRTV HSLTQALAKF 

       190        200        210        220        230        240 
KHNKFYFISP DALKMPNYIN NMLDKKEIYW KRHNNIEEII SEIDILYMTR IQKERLDSTE 

       250        260        270        280        290        300 
YANAKSKFVL RAAILKNARN NMKILHPLPR IDEIDRDVDY TPYAWYFKQA ANGIYARQAI 

       310 
LSLVLIEKHL

P57450 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools