[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND FUNCTION.
TISSUE=Fetal brain;
DOI=10.1073/pnas.94.18.9562; PubMed=9275162 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang D.,
Sliwkowski M.X.,
Mark M.,
Frantz G.,
Akita R.,
Sun Y.,
Hillan K.,
Crowley C.,
Brush J.,
Godowski P.J.;
"Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4.";
Proc. Natl. Acad. Sci. U.S.A. 94:9562-9567(1997).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, GLYCOSYLATION, AND FUNCTION.
TISSUE=Fetal brain;
DOI=10.1242/jcs.02799; PubMed=16478787 [NCBI, ExPASy, EBI, Israel, Japan]
Carteron C.,
Ferrer-Montiel A.V.,
Cabedo H.;
"Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival.";
J. Cell Sci. 119:898-909(2006).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
Tiao J.Y.,
Busfield S.J.;
"Bi-directional signalling by NRG-3 cytoplasmic domain.";
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02462; PubMed=15164054 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P.,
Earthrowl M.E.,
Grafham D.V.,
Rubenfield M.,
French L.,
Steward C.A.,
Sims S.K.,
Jones M.C.,
Searle S.,
Scott C.,
Howe K.,
Hunt S.E.,
Andrews T.D.,
Gilbert J.G.R.,
Swarbreck D.,
Ashurst J.L.,
Taylor A.,
Battles J.,
Bird C.P., ![]()
Ainscough R.,
Almeida J.P.,
Ashwell R.I.S.,
Ambrose K.D.,
Babbage A.K.,
Bagguley C.L.,
Bailey J.,
Banerjee R.,
Bates K.,
Beasley H.,
Bray-Allen S.,
Brown A.J.,
Brown J.Y.,
Burford D.C.,
Burrill W.,
Burton J.,
Cahill P.,
Camire D.,
Carter N.P.,
Chapman J.C.,
Clark S.Y.,
Clarke G.,
Clee C.M.,
Clegg S.,
Corby N.,
Coulson A.,
Dhami P.,
Dutta I.,
Dunn M.,
Faulkner L.,
Frankish A.,
Frankland J.A.,
Garner P.,
Garnett J.,
Gribble S.,
Griffiths C.,
Grocock R.,
Gustafson E.,
Hammond S.,
Harley J.L.,
Hart E.,
Heath P.D.,
Ho T.P.,
Hopkins B.,
Horne J.,
Howden P.J.,
Huckle E.,
Hynds C.,
Johnson C.,
Johnson D.,
Kana A.,
Kay M.,
Kimberley A.M.,
Kershaw J.K.,
Kokkinaki M.,
Laird G.K.,
Lawlor S.,
Lee H.M.,
Leongamornlert D.A.,
Laird G.,
Lloyd C.,
Lloyd D.M.,
Loveland J.,
Lovell J.,
McLaren S.,
McLay K.E.,
McMurray A.,
Mashreghi-Mohammadi M.,
Matthews L.,
Milne S.,
Nickerson T.,
Nguyen M.,
Overton-Larty E.,
Palmer S.A.,
Pearce A.V.,
Peck A.I.,
Pelan S.,
Phillimore B.,
Porter K.,
Rice C.M.,
Rogosin A.,
Ross M.T.,
Sarafidou T.,
Sehra H.K.,
Shownkeen R.,
Skuce C.D.,
Smith M.,
Standring L.,
Sycamore N.,
Tester J.,
Thorpe A.,
Torcasso W.,
Tracey A.,
Tromans A.,
Tsolas J.,
Wall M.,
Walsh J.,
Wang H.,
Weinstock K.,
West A.P.,
Willey D.L.,
Whitehead S.L.,
Wilming L.,
Wray P.W.,
Young L.,
Chen Y.,
Lovering R.C.,
Moschonas N.K.,
Siebert R.,
Fechtel K.,
Bentley D.,
Durbin R.M.,
Hubbard T.,
Doucette-Stamm L.,
Beck S.,
Smith D.R.,
Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 10.";
Nature 429:375-381(2004).
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[5]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116 AND SER-119, AND MASS SPECTROMETRY.
DOI=10.2116/analsci.24.161; PubMed=18187866 [NCBI, ExPASy, EBI, Israel, Japan]
Imami K.,
Sugiyama N.,
Kyono Y.,
Tomita M.,
Ishihama Y.;
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Anal. Sci. 24:161-166(2008).
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- FUNCTION: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
- SUBCELLULAR LOCATION: Pro-neuregulin-3, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein (By similarity). Note=Does not seem to be active (By similarity).
- SUBCELLULAR LOCATION: Neuregulin-3: Secreted (By similarity).
- SUBCELLULAR LOCATION: Isoform 3: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form.
- ALTERNATIVE PRODUCTS:
4 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Isoform ID | P56975-2 |
| Features which should be applied to build the isoform sequence: VSP_021830. |
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| Name | 4 |
| Isoform ID | P56975-4 |
| Features which should be applied to build the isoform sequence: VSP_035752. |
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- TISSUE SPECIFICITY: Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.
- DEVELOPMENTAL STAGE: Isoform 3 is expressed in fetal brain but not in other fetal tissues.
- DOMAIN: The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
- DOMAIN: ERBB receptor binding is elicited entirely by the EGF-like domain (By similarity).
- PTM: Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
- PTM: Extensive glycosylation precedes the proteolytic cleavage (By similarity). Isoform 3 is glycosylated.
- SIMILARITY: Belongs to the neuregulin family.
- SIMILARITY: Contains 1 EGF-like domain.
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