[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
TISSUE=Brain;
DOI=10.1126/science.286.5440.735; PubMed=10531052 [NCBI, ExPASy, EBI, Israel, Japan]
Vassar R.,
Bennett B.D.,
Babu-Khan S.,
Kahn S.,
Mendiaz E.A.,
Denis P.,
Teplow D.B.,
Ross S.,
Amarante P.,
Loeloff R.,
Luo Y.,
Fisher S.,
Fuller J.,
Edenson S.,
Lile J.,
Jarosinski M.A.,
Biere A.L.,
Curran E.,
Burgess T., ![]()
Louis J.-C.,
Collins F.,
Treanor J.,
Rogers G.,
Citron M.;
"Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.";
Science 286:735-741(1999).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), PROTEIN SEQUENCE OF 46-68, AND CHARACTERIZATION.
TISSUE=Brain;
DOI=10.1038/990114; PubMed=10591214 [NCBI, ExPASy, EBI, Israel, Japan]
Sinha S.,
Anderson J.P.,
Barbour R.,
Basi G.S.,
Caccavello R.,
Davis D.,
Doan M.,
Dovey H.F.,
Frigon N.,
Hong J.,
Jacobson-Croak K.,
Jewett N.,
Keim P.,
Knops J.,
Lieberburg I.,
Power M.,
Tan H.,
Tatsuno G.,
Tung J., ![]()
Schenk D.,
Seubert P.,
Suomensaari S.M.,
Wang S.,
Walker D.,
Zhao J.,
McConlogue L.,
Varghese J.;
"Purification and cloning of amyloid precursor protein beta-secretase from human brain.";
Nature 402:537-540(1999).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
DOI=10.1038/990107; PubMed=10591213 [NCBI, ExPASy, EBI, Israel, Japan]
Yan R.,
Bienkowski M.J.,
Shuck M.E.,
Miao H.,
Tory M.C.,
Pauley A.M.,
Brashier J.R.,
Stratman N.C.,
Mathews W.R.,
Buhl A.E.,
Carter D.B.,
Tomasselli A.G.,
Parodi L.A.,
Heinrikson R.L.,
Gurney M.E.;
"Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.";
Nature 402:533-537(1999).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
DOI=10.1006/mcne.1999.0811; PubMed=10656250 [NCBI, ExPASy, EBI, Israel, Japan]
Hussain I.,
Powell D.J.,
Howlett D.R.,
Tew D.G.,
Meek T.D.,
Chapman C.,
Gloger I.S.,
Murphy K.E.,
Southan C.D.,
Ryan D.M.,
Smith T.S.,
Simmons D.L.,
Walsh F.S.,
Dingwall C.,
Christie G.;
"Identification of a novel aspartic proteinase (Asp 2) as beta-secretase.";
Mol. Cell. Neurosci. 14:419-427(1999).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
TISSUE=Brain, and Pancreas;
Michel B.,
De Pietri Tonelli D.,
Zacchetti D.,
Keller P.;
"New beta-site APP cleaving enzyme isoform (BACE-1B) obtained from human brain and pancreas.";
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
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[6]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C).
TISSUE=Pancreas;
Zacchetti D.,
De Pietri Tonelli D.,
Schnurbus R.;
"New beta-site APP cleaving enzyme isoform (BACE-1C) obtained from human pancreas.";
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
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[7]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B; C AND D).
TISSUE=Brain;
DOI=10.1016/S0304-3940(01)01912-7; PubMed=11516562 [NCBI, ExPASy, EBI, Israel, Japan]
Tanahashi H.,
Tabira T.;
"Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production.";
Neurosci. Lett. 307:9-12(2001).
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[8]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
TISSUE=Brain;
DOI=10.1093/dnares/6.5.329; PubMed=10574461 [NCBI, ExPASy, EBI, Israel, Japan]
Hirosawa M.,
Nagase T.,
Ishikawa K.,
Kikuno R.,
Nomura N.,
Ohara O.;
"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.";
DNA Res. 6:329-336(1999).
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[9]
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SEQUENCE REVISION.
DOI=10.1093/dnares/9.3.99; PubMed=12168954 [NCBI, ExPASy, EBI, Israel, Japan]
Nakajima D.,
Okazaki N.,
Yamakawa H.,
Kikuno R.,
Ohara O.,
Nagase T.;
"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.";
DNA Res. 9:99-106(2002).
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[10]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[11]
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NUCLEOTIDE SEQUENCE [MRNA] OF 14-501 (ISOFORM A), AND CHARACTERIZATION.
DOI=10.1073/pnas.97.4.1456; PubMed=10677483 [NCBI, ExPASy, EBI, Israel, Japan]
Lin X.,
Koelsch G.,
Wu S.,
Downs D.,
Dashti A.,
Tang J.;
"Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein.";
Proc. Natl. Acad. Sci. U.S.A. 97:1456-1460(2000).
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[12]
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DISULFIDE BONDS.
PubMed=11953458 [NCBI, ExPASy, EBI, Israel, Japan]
Fischer F.,
Molinari M.,
Bodendorf U.,
Paganetti P.;
"The disulphide bonds in the catalytic domain of BACE are critical but not essential for amyloid precursor protein processing activity.";
J. Neurochem. 80:1079-1088(2002).
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[13]
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INTERACTION WITH GGA1; GGA2 AND GGA3.
DOI=10.1021/bi035199h; PubMed=14567678 [NCBI, ExPASy, EBI, Israel, Japan]
He X.,
Zhu G.,
Koelsch G.,
Rodgers K.K.,
Zhang X.C.,
Tang J.;
"Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins.";
Biochemistry 42:12174-12180(2003).
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[14]
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INTERACTION WITH RTN3 AND RTN4, AND ENZYME REGULATION.
DOI=10.1038/nm1088; PubMed=15286784 [NCBI, ExPASy, EBI, Israel, Japan]
He W.,
Lu Y.,
Qahwash I.,
Hu X.-Y.,
Chang A.,
Yan R.;
"Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation.";
Nat. Med. 10:959-965(2004).
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[15]
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INTERACTION WITH RTN3 AND RTN4, AND ENZYME REGULATION.
DOI=10.1111/j.1460-9568.2006.05005.x; PubMed=16965550 [NCBI, ExPASy, EBI, Israel, Japan]
Murayama K.S.,
Kametani F.,
Saito S.,
Kume H.,
Akiyama H.,
Araki W.;
"Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.";
Eur. J. Neurosci. 24:1237-1244(2006).
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[16]
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INTERACTION WITH RTN3.
DOI=10.1016/j.jmb.2006.07.094; PubMed=16979658 [NCBI, ExPASy, EBI, Israel, Japan]
He W.,
Hu X.,
Shi Q.,
Zhou X.,
Lu Y.,
Fisher C.,
Yan R.;
"Mapping of interaction domains mediating binding between BACE1 and RTN/Nogo proteins.";
J. Mol. Biol. 363:625-634(2006).
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[17]
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X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 56-446 IN COMPLEX WITH SUBSTRATE ANALOG.
DOI=10.1126/science.290.5489.150; PubMed=11021803 [NCBI, ExPASy, EBI, Israel, Japan]
Hong L.,
Koelsch G.,
Lin X.,
Wu S.,
Terzyan S.,
Ghosh A.K.,
Zhang X.C.,
Tang J.;
"Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor.";
Science 290:150-153(2000).
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[18]
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X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 56-446 IN COMPLEX WITH SUBSTRATE ANALOG.
DOI=10.1021/bi026232n; PubMed=12206667 [NCBI, ExPASy, EBI, Israel, Japan]
Hong L.,
Turner R.T. III,
Koelsch G.,
Shin D.,
Ghosh A.K.,
Tang J.;
"Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3.";
Biochemistry 41:10963-10967(2002).
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[19]
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X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 58-446.
DOI=10.1021/bi0498252; PubMed=15096037 [NCBI, ExPASy, EBI, Israel, Japan]
Hong L.,
Tang J.;
"Flap position of free memapsin 2 (beta-secretase), a model for flap opening in aspartic protease catalysis.";
Biochemistry 43:4689-4695(2004).
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[20]
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X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 43-453 IN COMPLEX WITH SUBSTRATE ANALOG.
DOI=10.1016/j.jmb.2004.08.018; PubMed=15451669 [NCBI, ExPASy, EBI, Israel, Japan]
Patel S.,
Vuillard L.,
Cleasby A.,
Murray C.W.,
Yon J.;
"Apo and inhibitor complex structures of BACE (beta-secretase).";
J. Mol. Biol. 343:407-416(2004).
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[21]
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X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 58-446.
DOI=10.1021/bi048106k; PubMed=15628850 [NCBI, ExPASy, EBI, Israel, Japan]
Turner R.T. III,
Hong L.,
Koelsch G.,
Ghosh A.K.,
Tang J.;
"Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase).";
Biochemistry 44:105-112(2005).
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