[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Brain; DOI=10.1016/S0167-4781(97)00205-4; PubMed=9540828 [NCBI, ExPASy, EBI, Israel, Japan] Proba K., Gschwend T.P., Sonderegger P.; "Cloning and sequencing of the cDNA encoding human neurotrypsin."; Biochim. Biophys. Acta 1396:143-147(1998).
[2]	NUCLEOTIDE SEQUENCE [MRNA] OF 615-875. TISSUE=Testis; DOI=10.1046/j.1432-1327.1999.00266.x; PubMed=10103056 [NCBI, ExPASy, EBI, Israel, Japan] Poorafshar M., Hellman L.; "Cloning and structural analysis of leydin, a novel human serine protease expressed by the Leydig cells of the testis."; Eur. J. Biochem. 261:244-250(1999).
[3]	DISEASE. DOI=10.1126/science.1076521; PubMed=12459588 [NCBI, ExPASy, EBI, Israel, Japan] Molinari F., Rio M., Meskenaite V., Encha-Razavi F., Auge J., Bacq D., Briault S., Vekemans M., Munnich A., Attie-Bitach T., Sonderegger P., Colleaux L.; "Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation."; Science 298:1779-1781(2002).

Comments

FUNCTION: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations (By similarity).
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Brian and Leydig cells of the testis.
DISEASE: Defects in PRSS12 are the cause of mental retardation autosomal recessive type 1 (MRT1) [MIM:249500]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.
SIMILARITY: Belongs to the peptidase S1 family [view classification].
SIMILARITY: Contains 1 kringle domain.
SIMILARITY: Contains 1 peptidase S1 domain [view classification].
SIMILARITY: Contains 4 SRCR domains.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ001531; CAA04816.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF077298; AAD25919.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00011063; -.

NP_003610.1; -.

3D structure databases

HSSP

P00760; 1EZX. [HSSP ENTRY / PDB]

ModBase

P56730.

Protein family/group databases

MEROPS

S01.237; -.

PTM databases

PhosphoSite

P56730; -.

Organism-specific databases

GC04M119483; -.

HIX0021866; -.

HGNC:9477; PRSS12.

249500; phenotype. [NCBI / EBI]
606709; gene. [NCBI / EBI]

Orphanet

88616; Intellectual deficit, nonsyndromic, autosomal recessive.

PharmGKB

PA33830; -.

Gene expression databases

P56730; -.

P56730; -.

HS_PRSS12; -.

ENSG00000164099; Homo sapiens.

Ontologies

GO:0016020;	Cellular component: membrane (inferred from electronic annotation from InterPro).
GO:0005044;	Molecular function: scavenger receptor activity (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR000001; Kringle.
IPR018056; Kringle_CS.
IPR018114; Peptidase_S1/S6_AS.
IPR001254; Peptidase_S1_S6.
IPR001190; Srcr_rcpt.
IPR017448; Srcr_rcpt-rel.
Graphical view of domain structure.

Pfam

PF00051; Kringle; 1.
PF00530; SRCR; 4.
PF00089; Trypsin; 1.
Pfam graphical view of domain structure.

ProDom

PD000395; Kringle; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00130; KR; 1.
SM00202; SR; 4.
SM00020; Tryp_SPc; 1.
SMART graphical view of domain structure.

PROSITE

PS00021; KRINGLE_1; 1.
PS50070; KRINGLE_2; 1.
PS00420; SRCR_1; 3.
PS50287; SRCR_2; 4.
PS50240; TRYPSIN_DOM; 1.
PS00134; TRYPSIN_HIS; 1.
PS00135; TRYPSIN_SER; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

P56730; -.

Genome annotation databases

Ensembl

ENSG00000164099; Homo sapiens. [Contig view]

GeneID

8492; -.

KEGG

hsa:8492; -.

Phylogenomic databases

HOGENOM

P56730; -.

HOVERGEN

P56730; -.

Other

NextBio

31771; -.

SOURCE

PRSS12; Homo sapiens.

ProtoNet

P56730.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Disulfide bond; Glycoprotein; Hydrolase; Kringle; Mental retardation; Polymorphism; Protease; Repeat; Secreted; Serine protease; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 20`	`20`	`Potential.`
`CHAIN`	`21 875`	`855`	`Neurotrypsin.`	`PRO_0000027663`
`DOMAIN`	`93 165`	`73`	`Kringle.`
`DOMAIN`	`170 271`	`102`	`SRCR 1.`
`DOMAIN`	`280 381`	`102`	`SRCR 2.`
`DOMAIN`	`387 487`	`101`	`SRCR 3.`
`DOMAIN`	`500 601`	`102`	`SRCR 4.`
`DOMAIN`	`631 874`	`244`	`Peptidase S1.`
`REGION`	`619 630`	`12`	`Zymogen activation region.`
`COMPBIAS`	`23 92`	`70`	`Pro-rich.`
`ACT_SITE`	`676 676`		`Charge relay system (By similarity).`
`ACT_SITE`	`726 726`		`Charge relay system (By similarity).`
`ACT_SITE`	`825 825`		`Charge relay system (By similarity).`
`SITE`	`630 631`	`2`	`Reactive bond homolog (Potential).`
`CARBOHYD`	`26 26`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`683 683`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`109 149`		`By similarity.`
`DISULFID`	`138 163`		`By similarity.`
`DISULFID`	`195 259`		`By similarity.`
`DISULFID`	`208 269`		`By similarity.`
`DISULFID`	`239 249`		`By similarity.`
`DISULFID`	`305 369`		`By similarity.`
`DISULFID`	`318 379`		`By similarity.`
`DISULFID`	`349 359`		`By similarity.`
`DISULFID`	`412 475`		`By similarity.`
`DISULFID`	`425 485`		`By similarity.`
`DISULFID`	`455 465`		`By similarity.`
`DISULFID`	`525 589`		`By similarity.`
`DISULFID`	`538 599`		`By similarity.`
`DISULFID`	`569 579`		`By similarity.`
`DISULFID`	`619 750`		`Potential.`
`DISULFID`	`661 677`		`By similarity.`
`DISULFID`	`765 831`		`By similarity.`
`DISULFID`	`794 808`		`By similarity.`
`DISULFID`	`821 850`		`By similarity.`
`VARIANT`	`606 606`	`1`	`A -> S (in dbSNP:rs28661939 [NCBI]).`	`VAR_051835`
`VARIANT`	`833 833`	`1`	`R -> Q (in dbSNP:rs17594503 [NCBI]).`	`VAR_051836`
`CONFLICT`	`663 663`		`A -> V (in Ref. 2; AAD25919).`
`CONFLICT`	`701 701`		`E -> V (in Ref. 2; AAD25919).`
`CONFLICT`	`839 841`		`VVY -> AAL (in Ref. 2; AAD25919).`

Sequence information

Length: 875 AA [This is the length of the unprocessed precursor]

Molecular weight: 97012 Da [This is the MW of the unprocessed precursor]

CRC64: B66EC946DC208DC8 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTLARFVLAL MLGALPEVVG FDSVLNDSLH HSHRHSPPAG PHYPYYLPTQ QRPPTTRPPP 

        70         80         90        100        110        120 
PLPRFPRPPR ALPAQRPHAL QAGHTPRPHP WGCPAGEPWV SVTDFGAPCL RWAEVPPFLE 

       130        140        150        160        170        180 
RSPPASWAQL RGQRHNFCRS PDGAGRPWCF YGDARGKVDW GYCDCRHGSV RLRGGKNEFE 

       190        200        210        220        230        240 
GTVEVYASGV WGTVCSSHWD DSDASVICHQ LQLGGKGIAK QTPFSGLGLI PIYWSNVRCR 

       250        260        270        280        290        300 
GDEENILLCE KDIWQGGVCP QKMAAAVTCS FSHGPTFPII RLAGGSSVHE GRVELYHAGQ 

       310        320        330        340        350        360 
WGTVCDDQWD DADAEVICRQ LGLSGIAKAW HQAYFGEGSG PVMLDEVRCT GNELSIEQCP 

       370        380        390        400        410        420 
KSSWGEHNCG HKEDAGVSCT PLTDGVIRLA GGKGSHEGRL EVYYRGQWGT VCDDGWTELN 

       430        440        450        460        470        480 
TYVVCRQLGF KYGKQASANH FEESTGPIWL DDVSCSGKET RFLQCSRRQW GRHDCSHRED 

       490        500        510        520        530        540 
VSIACYPGGE GHRLSLGFPV RLMDGENKKE GRVEVFINGQ WGTICDDGWT DKDAAVICRQ 

       550        560        570        580        590        600 
LGYKGPARAR TMAYFGEGKG PIHVDNVKCT GNERSLADCI KQDIGRHNCR HSEDAGVICD 

       610        620        630        640        650        660 
YFGKKASGNS NKESLSSVCG LRLLHRRQKR IIGGKNSLRG GWPWQVSLRL KSSHGDGRLL 

       670        680        690        700        710        720 
CGATLLSSCW VLTAAHCFKR YGNSTRSYAV RVGDYHTLVP EEFEEEIGVQ QIVIHREYRP 

       730        740        750        760        770        780 
DRSDYDIALV RLQGPEEQCA RFSSHVLPAC LPLWRERPQK TASNCYITGW GDTGRAYSRT 

       790        800        810        820        830        840 
LQQAAIPLLP KRFCEERYKG RFTGRMLCAG NLHEHKRVDS CQGDSGGPLM CERPGESWVV 

       850        860        870 
YGVTSWGYGC GVKDSPGVYT KVSAFVPWIK SVTKL

P56730 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools