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UniProtKB/Swiss-Prot entry P56704


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name WNT3A_HUMAN
Primary accession number P56704
Secondary accession numbers Q3SY80 Q969P2
Integrated into Swiss-Prot on July 15, 1999
Sequence was last modified on May 10, 2002 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 71)
Name and origin of the protein
Protein name Protein Wnt-3a [Precursor]
Synonyms None
Gene name
Name: WNT3A
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1006/bbrc.2001.5105; PubMed=11414706 [NCBI, ExPASy, EBI, Israel, Japan]
Saitoh T., Hirai M., Katoh M.;
"Molecular cloning and characterization of WNT3a and WNT14 clustered in human chromosome 1q42 region.";
Biochem. Biophys. Res. Commun. 284:1168-1175(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 207-330.
TISSUE=Mammary gland;
PubMed=8168088 [NCBI, ExPASy, EBI, Israel, Japan]
Huguet E.L., McMahon J.A., McMahon A.P., Bicknell R., Harris A.L.;
"Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue.";
Cancer Res. 54:2615-2621(1994).
Comments
  • FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.
  • SUBUNIT: Interacts with PORCN (By similarity).
  • SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
  • TISSUE SPECIFICITY: Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate.
  • SIMILARITY: Belongs to the Wnt family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB060284; BAB61052.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK056278; BAB71136.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL136379; CAI23122.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC103922; AAI03923.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00654606; -.
RefSeq NP_149122.1; -.
UniGene Hs.336930
3D structure databases
ModBase P56704.
Organism-specific databases
GeneCards GC01P226261; -.
HGNC HGNC:15983; WNT3A.
GenAtlas WNT3A.
MIM 606359; gene. [NCBI / EBI]
PharmGKB PA38074; -.
Gene expression databases
ArrayExpress P56704; -.
Bgee P56704; -.
CleanEx HS_WNT3A; -.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005578; Cellular component: proteinaceous extracellular matrix (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005201; Molecular function: extracellular matrix structural constituent (non-traceable author statement from UniProtKB).
GO:0004871; Molecular function: signal transducer activity (inferred from electronic annotation from InterPro).
GO:0007267; Biological process: cell-cell signaling (non-traceable author statement from UniProtKB).
GO:0007223; Biological process: Wnt receptor signaling pathway, calcium modulating pathway (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR009141; Wnt3.
IPR005816; Wnt_grthfactor.
IPR018161; Wnt_grthfactor_CS.
IPR005817; Wnt_SF.
Graphical view of domain structure.
PANTHER PTHR12027; Wnt; 1.
PTHR12027:SF18; Wnt3; 1.
Pfam PF00110; wnt; 1.
Pfam graphical view of domain structure.
PRINTS PR01843; WNT3PROTEIN.
PR01349; WNTPROTEIN.
SMART SM00097; WNT1; 1.
SMART graphical view of domain structure.
PROSITE PS00246; WNT1; 1.
Proteomic databases
PRIDE P56704; -.
Genome annotation databases
Ensembl ENSG00000154342; Homo sapiens. [Contig view]
GeneID 89780; -.
KEGG hsa:89780; -.
Phylogenomic databases
HOVERGEN P56704; -.
Other
NextBio 76263; -.
SOURCE WNT3A; Homo sapiens.
ProtoNet P56704.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Developmental protein; Extracellular matrix; Glycoprotein; Lipoprotein; Palmitate; Secreted; Signal; Wnt signaling pathway.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    24  24     Potential. 
CHAIN   25   352  328     Protein Wnt-3a. PRO_0000041418
LIPID   77    77        S-palmitoyl cysteine (By similarity). 
CARBOHYD   87    87        N-linked (GlcNAc...) (Potential). 
CARBOHYD   298   298        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 352 AA [This is the length of the unprocessed precursor] Molecular weight: 39365 Da [This is the MW of the unprocessed precursor] CRC64: A317BD6D4A73920B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAPLGYFLLL CSLKQALGSY PIWWSLAVGP QYSSLGSQPI LCASIPGLVP KQLRFCRNYV 

        70         80         90        100        110        120 
EIMPSVAEGI KIGIQECQHQ FRGRRWNCTT VHDSLAIFGP VLDKATRESA FVHAIASAGV 

       130        140        150        160        170        180 
AFAVTRSCAE GTAAICGCSS RHQGSPGKGW KWGGCSEDIE FGGMVSREFA DARENRPDAR 

       190        200        210        220        230        240 
SAMNRHNNEA GRQAIASHMH LKCKCHGLSG SCEVKTCWWS QPDFRAIGDF LKDKYDSASE 

       250        260        270        280        290        300 
MVVEKHRESR GWVETLRPRY TYFKVPTERD LVYYEASPNF CEPNPETGSF GTRDRTCNVS 

       310        320        330        340        350 
SHGIDGCDLL CCGRGHNARA ERRREKCRCV FHWCCYVSCQ ECTRVYDVHT CK 

P56704 in FASTA format

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