[1]	NUCLEOTIDE SEQUENCE [MRNA]. Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y., Kelsell D.P., Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A., Culbert A.A., Reith A.D., Barnes M.R.; "Molecular cloning and characterization of six novel human WNT genes."; Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
[2]	NUCLEOTIDE SEQUENCE [MRNA]. PubMed=11604997 [NCBI, ExPASy, EBI, Israel, Japan] Katoh M.; "Molecular cloning and characterization of human WNT3."; Int. J. Oncol. 19:977-982(2001).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[4]	NUCLEOTIDE SEQUENCE [MRNA] OF 1-333. DOI=10.1006/geno.1993.1412; PubMed=8244403 [NCBI, ExPASy, EBI, Israel, Japan] Roelink H., Wang J., Black D.M., Solomon E., Nusse R.; "Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene."; Genomics 17:790-792(1993).
[5]	INVOLVEMENT IN TETRA-AMELIA. DOI=10.1086/382196; PubMed=14872406 [NCBI, ExPASy, EBI, Israel, Japan] Niemann S., Zhao C., Pascu F., Stahl U., Aulepp U., Niswander L., Weber J.L., Mueller U.; "Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family."; Am. J. Hum. Genet. 74:558-563(2004).

Comments

FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube (By similarity).
SUBUNIT: Interacts with PORCN (By similarity).
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
DISEASE: Defects in WNT3 are the cause of autosomal recessive tetra-amelia [MIM:273395]. Tetra-amelia is a rare human genetic disorder characterized by complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects.
SIMILARITY: Belongs to the Wnt family.
WEB RESOURCE: Name=GeneReviews; URL="http://www.genetests.org/query?gene=WNT3";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY009397; AAG38657.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB067628; BAB70502.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC112116; AAI12117.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC112118; AAI12119.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC114219; AAI14220.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00011023; -.

A47536; A47536.

NP_110380.1; -.

3D structure databases

ModBase

P56703.

Organism-specific databases

GC17M042196; -.

HGNC:12782; WNT3.

165330; gene. [NCBI / EBI]
273395; phenotype. [NCBI / EBI]

Orphanet

1027; Amelia, autosomal recessive.
3300; Tetraamelia - pulmonary hypoplasia.

PharmGKB

PA37383; -.

Gene expression databases

P56703; -.

P56703; -.

HS_WNT3; -.

ENSG00000108379; Homo sapiens.

Ontologies

GO:0005615;	Cellular component: extracellular space (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005578;	Cellular component: proteinaceous extracellular matrix (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005201;	Molecular function: extracellular matrix structural constituent (non-traceable author statement from UniProtKB).
GO:0004871;	Molecular function: signal transducer activity (inferred from electronic annotation from InterPro).
GO:0007223;	Biological process: Wnt receptor signaling pathway, calcium modulating pathway (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR009141; Wnt3.
IPR005816; Wnt_grthfactor.
IPR018161; Wnt_grthfactor_CS.
IPR005817; Wnt_SF.
Graphical view of domain structure.

PANTHER

PTHR12027; Wnt; 1.
PTHR12027:SF18; Wnt3; 1.

Pfam

PF00110; wnt; 1.
Pfam graphical view of domain structure.

PRINTS

PR01843; WNT3PROTEIN.
PR01349; WNTPROTEIN.

SMART

SM00097; WNT1; 1.
SMART graphical view of domain structure.

PROSITE

PS00246; WNT1; 1.

Proteomic databases

PRIDE

P56703; -.

Genome annotation databases

Ensembl

ENSG00000108379; Homo sapiens. [Contig view]

GeneID

7473; -.

KEGG

hsa:7473; -.

Phylogenomic databases

HOGENOM

P56703; -.

HOVERGEN

P56703; -.

OMA

P56703; NCTTIHD.

Other

29272; -.

WNT3; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Developmental protein; Extracellular matrix; Glycoprotein; Proto-oncogene; Secreted; Signal; Wnt signaling pathway.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 21`	`21`	`Potential.`
`CHAIN`	`22 355`	`334`	`Proto-oncogene protein Wnt-3.`	`PRO_0000041416`
`CARBOHYD`	`90 90`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`301 301`		`N-linked (GlcNAc...) (Potential).`

Sequence information

Length: 355 AA [This is the length of the unprocessed precursor]

Molecular weight: 39645 Da [This is the MW of the unprocessed precursor]

CRC64: 85D15F2C7884A64F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEPHLLGLLL GLLLGGTRVL AGYPIWWSLA LGQQYTSLGS QPLLCGSIPG LVPKQLRFCR 

        70         80         90        100        110        120 
NYIEIMPSVA EGVKLGIQEC QHQFRGRRWN CTTIDDSLAI FGPVLDKATR ESAFVHAIAS 

       130        140        150        160        170        180 
AGVAFAVTRS CAEGTSTICG CDSHHKGPPG EGWKWGGCSE DADFGVLVSR EFADARENRP 

       190        200        210        220        230        240 
DARSAMNKHN NEAGRTTILD HMHLKCKCHG LSGSCEVKTC WWAQPDFRAI GDFLKDKYDS 

       250        260        270        280        290        300 
ASEMVVEKHR ESRGWVETLR AKYSLFKPPT ERDLVYYENS PNFCEPNPET GSFGTRDRTC 

       310        320        330        340        350 
NVTSHGIDGC DLLCCGRGHN TRTEKRKEKC HCIFHWCCYV SCQECIRIYD VHTCK

P56703 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools