ID PER3_HUMAN Reviewed; 1201 AA. AC P56645; Q5H8X4; Q969K6; Q96S77; Q96S78; Q9C0J3; Q9NSP9; Q9UGU8; DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot. DT 24-MAY-2005, sequence version 3. DT 10-JUN-2008, entry version 70. DE Period circadian protein homolog 3 (Circadian clock protein PERIOD 3) DE (hPER3) (Cell growth-inhibiting gene 13 protein). GN Name=PER3; ORFNames=GIG13; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RA Nagase T., Kikuno R., Ohara O.; RT "Homo sapiens mRNA for period (Drosophila) homolog 3 (hPer3), complete RT cds."; RL Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-827. RA Rhodes S., Huckle E.; RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-827. RA Kim J.W.; RT "Identification of a growth inhibition gene."; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT LEU-827. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., RA Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 44-91 AND 724-882, AND VARIANTS RP GLY-639; ALA-856; THR-1028 AND ARG-1149. RX PubMed=11306557; DOI=10.1093/embo-reports/kve070; RA Ebisawa T., Uchiyama M., Kajimura N., Mishima K., Kamei Y., Katoh M., RA Watanabe T., Sekimoto M., Shibui K., Kim K., Kudo Y., Ozeki Y., RA Sugishita M., Toyoshima R., Inoue Y., Yamada N., Nagase T., Ozaki N., RA Ohara O., Ishida N., Okawa M., Takahashi K., Yamauchi T.; RT "Association of structural polymorphisms in the human period3 gene RT with delayed sleep phase syndrome."; RL EMBO Rep. 2:342-346(2001). RN [6] RP VARIANT GLY-639. RX PubMed=12655319; DOI=10.1038/sj.npp.1300121; RA Johansson C., Willeit M., Smedh C., Ekholm J., Paunio T., Kieseppa T., RA Lichtermann D., Praschak-Rieder N., Neumeister A., Nilsson L.G., RA Kasper S., Peltonen L., Adolfsson R., Schalling M., Partonen T.; RT "Circadian clock-related polymorphisms in seasonal affective disorder RT and their relevance to diurnal preference."; RL Neuropsychopharmacology 28:734-739(2003). CC -!- FUNCTION: Component of the circadian clock mechanism which is CC essential for generating circadian rhythms. Function unknown. CC -!- SUBUNIT: Homodimer. Component of the circadian core oscillator, CC which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CC CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts CC directly with PER1, PER2, CRY1, CRY2, and TIMELESS. Interaction CC with CSNK1D or CSKN1E promotes nuclear location of PER proteins CC (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By CC similarity). Note=Mainly cytoplasmic. Translocates to the nucleus CC through binding PER1, PER2, CRY1 or CRY2, but not TIMELESS (By CC similarity). CC -!- PTM: Phosphorylation appears to require association with PER1 and CC translocation to the nucleus (By similarity). CC -!- PTM: Ubiquitinated (By similarity). CC -!- SIMILARITY: Contains 1 PAC (PAS-associated C-terminal) domain. CC -!- SIMILARITY: Contains 2 PAS (PER-ARNT-SIM) domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AB047686; BAB32925.2; ALT_INIT; mRNA. DR EMBL; AL157954; CAB76084.1; -; mRNA. DR EMBL; AY493418; AAS72879.1; -; mRNA. DR EMBL; Z98884; CAI21436.1; -; Genomic_DNA. DR EMBL; AB047521; BAB63250.1; -; Genomic_DNA. DR EMBL; AB047530; BAB63251.1; -; Genomic_DNA. DR EMBL; AB047531; BAB63252.1; -; Genomic_DNA. DR EMBL; AB047532; BAB63253.1; -; Genomic_DNA. DR EMBL; AB047533; BAB63254.1; -; Genomic_DNA. DR EMBL; AB047534; BAB63255.1; -; Genomic_DNA. DR RefSeq; NP_058515.1; -. DR UniGene; Hs.533339; -. DR PhosphoSite; P56645; -. DR Ensembl; ENSG00000049246; Homo sapiens. DR GeneID; 8863; -. DR KEGG; hsa:8863; -. DR HGNC; HGNC:8847; PER3. DR MIM; 603427; gene. DR PharmGKB; PA134911185; -. DR HOVERGEN; P56645; -. DR LinkHub; P56645; -. DR ArrayExpress; P56645; -. DR CleanEx; HS_PER3; -. DR GermOnline; ENSG00000049246; Homo sapiens. DR InterPro; IPR001610; PAC. DR InterPro; IPR000014; PAS. DR InterPro; IPR000700; PAS-assoc_C. DR InterPro; IPR013655; PAS_3. DR Pfam; PF08447; PAS_3; 1. DR SMART; SM00086; PAC; 1. DR SMART; SM00091; PAS; 2. DR PROSITE; PS50113; PAC; FALSE_NEG. DR PROSITE; PS50112; PAS; 1. PE 2: Evidence at transcript level; KW Biological rhythms; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; KW Repeat; Transcription; Transcription regulation; Ubl conjugation. FT CHAIN 1 1201 Period circadian protein homolog 3. FT /FTId=PRO_0000162633. FT DOMAIN 121 188 PAS 1. FT DOMAIN 262 328 PAS 2. FT DOMAIN 337 380 PAC. FT REGION 502 731 CSNK1E binding domain (By similarity). FT REGION 1123 1201 CRY binding domain (By similarity). FT MOTIF 400 412 Nuclear export signal (By similarity). FT MOTIF 729 745 Nuclear localization signal (By FT similarity). FT COMPBIAS 567 570 Poly-Ser. FT COMPBIAS 750 753 Poly-Ser. FT COMPBIAS 769 895 Pro-rich. FT COMPBIAS 962 1081 Ser-rich. FT VARIANT 639 639 V -> G (associated with delayed sleep FT phase syndrome (DSPS); dbSNP:rs10462020). FT /FTId=VAR_025532. FT VARIANT 827 827 P -> L (in dbSNP:rs228696). FT /FTId=VAR_022428. FT VARIANT 856 856 P -> A (in dbSNP:rs228697). FT /FTId=VAR_015514. FT VARIANT 1007 1007 A -> T (in dbSNP:rs1776342). FT /FTId=VAR_028728. FT VARIANT 1010 1010 T -> I (in dbSNP:rs12033719). FT /FTId=VAR_028729. FT VARIANT 1028 1028 M -> T (in dbSNP:rs2640909). FT /FTId=VAR_025533. FT VARIANT 1081 1081 S -> C (in dbSNP:rs2640905). FT /FTId=VAR_028730. FT VARIANT 1149 1149 H -> R (in dbSNP:rs10462021). FT /FTId=VAR_025534. FT CONFLICT 199 199 A -> AA (in Ref. 1; BAB32925). FT CONFLICT 501 501 E -> ESANGGGE (in Ref. 1; BAB32925). FT CONFLICT 943 943 Q -> R (in Ref. 1; BAB32925). FT CONFLICT 954 954 Y -> YQ (in Ref. 1; BAB32925). SQ SEQUENCE 1201 AA; 131872 MW; FD69C34865F11A6F CRC64; MPRGEAPGPG RRGAKDEALG EESGERWSPE FHLQRKLADS SHSEQQDRNR VSEELIMVVQ EMKKYFPSER RNKPSTLDAL NYALRCVHSV QANSEFFQIL SQNGAPQADV SMYSLEELAT IASEHTSKNT DTFVAVFSFL SGRLVHISEQ AALILNRKKD VLASSHFVDL LAPQDMRVFY AHTARAQLPF WNNWTQRAAR YECAPVKPFF CRIRGGEDRK QEKCHSPFRI IPYLIHVHHP AQPELESEPC CLTVVEKIHS GYEAPRIPVN KRIFTTTHTP GCVFLEVDEK AVPLLGYLPQ DLIGTSILSY LHPEDRSLMV AIHQKVLKYA GHPPFEHSPI RFCTQNGDYI ILDSSWSSFV NPWSRKISFI IGRHKVRTSP LNEDVFATKI KKMNDNDKDI TELQEQIYKL LLQPVHVSVS SGYGSLGSSG SQEQLVSIAS SSEASGHRVE ETKAEQMTLQ QVYASVNKIK NLGQQLYIES MTKSSFKPVT GTRTEPNGGG ECKTFTSFHQ TLKNNSVYTE PCEDLRNDEH SPSYQQINCI DSVIRYLKSY NIPALKRKCI SCTNTTSSSS EEDKQNHKAD DVQALQAGLQ IPAIPKSEMP TNGRSIDTGG GAPQILSTAM LSLGSGISQC GYSSTIVHVP PPETARDATL FCEPWTLNMQ PAPLTSEEFK HVGLTAAVLS AHTQKEEQNY VDKFREKILS SPYSSYLQQE SRSKAKYSYF QGDSTSKQTR SAGCRKGKHK RKKLPEPPDS SSSNTGSGPR RGAHQNAQPC CPSAASSPHT SSPTFPPAAM VPSQAPYLVP AFPLPAATSP GREYAAPGTA PEGLHGPPLS EGLQPYPAFP FPYLDTFMTV FLPDPPVCPL LSPSFLPCPF LGATASSAIS PSMSSAMSPT LDPPPSVTSQ RREEEKWEAQ SEGHPFITSR SSSPLQLNLL QEEMPRPSES PDQMRRNTCP QTEYCVTGNN GSESSPATTG ALSTGSPPRE NPSHPTASAL STGSPPMKNP SHPTASALST GSPPMKNPSH PTASTLSMGL PPSRTPSHPT ATVLSTGSPP SESPSRTGSA ASGSSDSSIY LTSSVYSSKI SQNGQQSQDV QKKETFPNVA EEPIWRMIRQ TPERILMTYQ VPERVKEVVL KEDLEKLESM RQQQPQFSHG QKEELAKVYN WIQSQTVTQE IDIQACVTCE NEDSADGAAT SCGQVLVEDS C //