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UniProtKB/Swiss-Prot entry P56645


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PER3_HUMAN
Primary accession number P56645
Secondary accession numbers Q5H8X4 Q969K6 Q96S77 Q96S78 Q9C0J3 Q9NSP9 Q9UGU8
Integrated into Swiss-Prot on July 15, 1999
Sequence was last modified on May 24, 2005 (Sequence version 3)
Annotations were last modified on    February 26, 2008 (Entry version 68)
Name and origin of the protein
Protein name Period circadian protein homolog 3
Synonyms Circadian clock protein PERIOD 3
hPER3
Cell growth-inhibiting gene 13 protein
Gene name
Name: PER3
ORFNames: GIG13
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
Nagase T., Kikuno R., Ohara O.;
"Homo sapiens mRNA for period (Drosophila) homolog 3 (hPer3), complete cds.";
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-827.
Rhodes S., Huckle E.;
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-827.
Kim J.W.;
"Identification of a growth inhibition gene.";
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT LEU-827.
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 44-91 AND 724-882, AND VARIANTS GLY-639; ALA-856; THR-1028 AND ARG-1149.
DOI=10.1093/embo-reports/kve070; PubMed=11306557 [NCBI, ExPASy, EBI, Israel, Japan]
Ebisawa T., Uchiyama M., Kajimura N., Mishima K., Kamei Y., Katoh M., Watanabe T., Sekimoto M., Shibui K., Kim K., Kudo Y., Ozeki Y., Sugishita M., Toyoshima R., Inoue Y., Yamada N., Nagase T., Ozaki N., Ohara O., Ishida N., Okawa M., Takahashi K., Yamauchi T.;
"Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome.";
EMBO Rep. 2:342-346(2001).
[6]
VARIANT GLY-639.
DOI=10.1038/sj.npp.1300121; PubMed=12655319 [NCBI, ExPASy, EBI, Israel, Japan]
Johansson C., Willeit M., Smedh C., Ekholm J., Paunio T., Kieseppa T., Lichtermann D., Praschak-Rieder N., Neumeister A., Nilsson L.G., Kasper S., Peltonen L., Adolfsson R., Schalling M., Partonen T.;
"Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference.";
Neuropsychopharmacology 28:734-739(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB047686; BAB32925.2; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL157954; CAB76084.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY493418; AAS72879.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z98884; CAI21436.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB047521; BAB63250.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB047530; BAB63251.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB047531; BAB63252.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB047532; BAB63253.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB047533; BAB63254.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB047534; BAB63255.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_058515.1; -.
UniGene Hs.533339
3D structure databases
ModBase P56645.
PTM databases
PhosphoSite P56645; -.
Organism-specific databases
HGNC HGNC:8847; PER3.
GeneLynx PER3; Homo sapiens.
GenAtlas PER3.
MIM 603427; gene. [NCBI / EBI]
PharmGKB PA134911185; -.
GeneCards P56645.
Gene expression databases
ArrayExpress P56645; -.
CleanEx HS_PER3; -.
GermOnline ENSG00000049246; Homo sapiens.
Family and domain databases
InterPro IPR001610; PAC.
IPR000014; PAS.
IPR000700; PAS-assoc_C.
IPR013655; PAS_3.
Graphical view of domain structure.
Pfam PF08447; PAS_3; 1.
Pfam graphical view of domain structure.
SMART SM00086; PAC; 1.
SM00091; PAS; 2.
SMART graphical view of domain structure.
PROSITE PS50113; PAC; FALSE_NEG.
PS50112; PAS; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P56645.
Genome annotation databases
Ensembl ENSG00000049246; Homo sapiens. [Contig view]
GeneID 8863; -.
Other
LinkHub P56645; -.
SOURCE PER3; Homo sapiens.
ProtoNet P56645.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Biological rhythms; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Repeat; Transcription; Transcription regulation; Ubl conjugation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1201  1201     Period circadian protein homolog 3. PRO_0000162633
DOMAIN   121    188  68     PAS 1. 
DOMAIN   262    328  67     PAS 2. 
DOMAIN   337    380  44     PAC. 
REGION   502    731  230     CSNK1E binding domain (By similarity). 
REGION   1123   1201  79     CRY binding domain (By similarity). 
MOTIF   400    412  13     Nuclear export signal (By similarity). 
MOTIF   729    745  17     Nuclear localization signal (By similarity). 
COMPBIAS   567    570  4     Poly-Ser. 
COMPBIAS   750    753  4     Poly-Ser. 
COMPBIAS   769    895  127     Pro-rich. 
COMPBIAS   962   1081  120     Ser-rich. 
VARIANT   639    639  1     V -> G (associated with delayed sleep phase syndrome (DSPS); dbSNP:rs10462020 [NCBI]). VAR_025532 
VARIANT   827    827  1     P -> L (in dbSNP:rs228696 [NCBI]). VAR_022428 
VARIANT   856    856  1     P -> A (in dbSNP:rs228697 [NCBI]). VAR_015514 
VARIANT   1007   1007  1     A -> T (in dbSNP:rs1776342 [NCBI]). VAR_028728 
VARIANT   1010   1010  1     T -> I (in dbSNP:rs12033719 [NCBI]). VAR_028729 
VARIANT   1028   1028  1     M -> T (in dbSNP:rs2640909 [NCBI]). VAR_025533 
VARIANT   1081   1081  1     S -> C (in dbSNP:rs2640905 [NCBI]). VAR_028730 
VARIANT   1149   1149  1     H -> R (in dbSNP:rs10462021 [NCBI]). VAR_025534 
CONFLICT   199    199        A -> AA (in Ref. 1; BAB32925). 
CONFLICT   501    501        E -> ESANGGGE (in Ref. 1; BAB32925). 
CONFLICT   943    943        Q -> R (in Ref. 1; BAB32925). 
CONFLICT   954    954        Y -> YQ (in Ref. 1; BAB32925). 
Sequence information
Length: 1201 AA [This is the length of the unprocessed precursor] Molecular weight: 131872 Da [This is the MW of the unprocessed precursor] CRC64: FD69C34865F11A6F [This is a checksum on the sequence]
        10         20         30         40         50         60 
MPRGEAPGPG RRGAKDEALG EESGERWSPE FHLQRKLADS SHSEQQDRNR VSEELIMVVQ 

        70         80         90        100        110        120 
EMKKYFPSER RNKPSTLDAL NYALRCVHSV QANSEFFQIL SQNGAPQADV SMYSLEELAT 

       130        140        150        160        170        180 
IASEHTSKNT DTFVAVFSFL SGRLVHISEQ AALILNRKKD VLASSHFVDL LAPQDMRVFY 

       190        200        210        220        230        240 
AHTARAQLPF WNNWTQRAAR YECAPVKPFF CRIRGGEDRK QEKCHSPFRI IPYLIHVHHP 

       250        260        270        280        290        300 
AQPELESEPC CLTVVEKIHS GYEAPRIPVN KRIFTTTHTP GCVFLEVDEK AVPLLGYLPQ 

       310        320        330        340        350        360 
DLIGTSILSY LHPEDRSLMV AIHQKVLKYA GHPPFEHSPI RFCTQNGDYI ILDSSWSSFV 

       370        380        390        400        410        420 
NPWSRKISFI IGRHKVRTSP LNEDVFATKI KKMNDNDKDI TELQEQIYKL LLQPVHVSVS 

       430        440        450        460        470        480 
SGYGSLGSSG SQEQLVSIAS SSEASGHRVE ETKAEQMTLQ QVYASVNKIK NLGQQLYIES 

       490        500        510        520        530        540 
MTKSSFKPVT GTRTEPNGGG ECKTFTSFHQ TLKNNSVYTE PCEDLRNDEH SPSYQQINCI 

       550        560        570        580        590        600 
DSVIRYLKSY NIPALKRKCI SCTNTTSSSS EEDKQNHKAD DVQALQAGLQ IPAIPKSEMP 

       610        620        630        640        650        660 
TNGRSIDTGG GAPQILSTAM LSLGSGISQC GYSSTIVHVP PPETARDATL FCEPWTLNMQ 

       670        680        690        700        710        720 
PAPLTSEEFK HVGLTAAVLS AHTQKEEQNY VDKFREKILS SPYSSYLQQE SRSKAKYSYF 

       730        740        750        760        770        780 
QGDSTSKQTR SAGCRKGKHK RKKLPEPPDS SSSNTGSGPR RGAHQNAQPC CPSAASSPHT 

       790        800        810        820        830        840 
SSPTFPPAAM VPSQAPYLVP AFPLPAATSP GREYAAPGTA PEGLHGPPLS EGLQPYPAFP 

       850        860        870        880        890        900 
FPYLDTFMTV FLPDPPVCPL LSPSFLPCPF LGATASSAIS PSMSSAMSPT LDPPPSVTSQ 

       910        920        930        940        950        960 
RREEEKWEAQ SEGHPFITSR SSSPLQLNLL QEEMPRPSES PDQMRRNTCP QTEYCVTGNN 

       970        980        990       1000       1010       1020 
GSESSPATTG ALSTGSPPRE NPSHPTASAL STGSPPMKNP SHPTASALST GSPPMKNPSH 

      1030       1040       1050       1060       1070       1080 
PTASTLSMGL PPSRTPSHPT ATVLSTGSPP SESPSRTGSA ASGSSDSSIY LTSSVYSSKI 

      1090       1100       1110       1120       1130       1140 
SQNGQQSQDV QKKETFPNVA EEPIWRMIRQ TPERILMTYQ VPERVKEVVL KEDLEKLESM 

      1150       1160       1170       1180       1190       1200 
RQQQPQFSHG QKEELAKVYN WIQSQTVTQE IDIQACVTCE NEDSADGAAT SCGQVLVEDS 


C 

P56645 in FASTA format

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