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[1]
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NUCLEOTIDE SEQUENCE.
STRAIN=129;
DOI=10.1126/science.278.5335.135; PubMed=9311920 [NCBI, ExPASy, EBI, Israel, Japan]
Ollmann M.M.,
Wilson B.D.,
Yang Y.K.,
Kerns J.A.,
Chen Y.,
Gantz I.,
Barsh G.S.;
"Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein.";
Science 278:135-138(1997).
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[2]
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NUCLEOTIDE SEQUENCE.
PubMed=9119224 [NCBI, ExPASy, EBI, Israel, Japan]
Shutter J.R.,
Graham M.,
Kinsey A.C.,
Scully S.,
Luethy R.,
Stark K.L.;
"Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.";
Genes Dev. 11:593-602(1997).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6;
TISSUE=Eye;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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- FUNCTION: Plays a role in weight homeostasis. May play a role in the regulation of melanocortin receptors within the hypothalamus and adrenal gland, and therefore in the central control of feeding.
- SUBCELLULAR LOCATION: Secreted.
- TISSUE SPECIFICITY: Expressed in arcuate nucleus and median eminence, adrenal gland (medulla), hypothalamus, testis, and lung.
- INDUCTION: Hypothalamic expression is elevated circa 10-fold in ob/ob and db/db mice.
- DOMAIN: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin (By similarity).
- SIMILARITY: Contains 1 agouti domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 131 AA [This is the length of the unprocessed precursor] |
Molecular weight: 14432 Da [This is the MW of the unprocessed precursor] |
CRC64: 25D9766D074C6834 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MLTAMLLSCV LLLALPPTLG VQMGVAPLKG IRRPDQALFP EFPGLSLNGL KKTTADRAEE
70 80 90 100 110 120
VLLQKAEALA EVLDPQNRES RSPRRCVRLH ESCLGQQVPC CDPCATCYCR FFNAFCYCRK
130
LGTATNLCSR T
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P56473 in FASTA format |
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