ID   DHOM_HELPY              Reviewed;         421 AA.
AC   P56429;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   22-JUL-2008, entry version 53.
DE   RecName: Full=Homoserine dehydrogenase;
DE            Short=HDH;
DE            EC=1.1.1.3;
GN   Name=hom; OrderedLocusNames=HP_0822;
OS   Helicobacter pylori (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=210;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   MEDLINE=97394467; PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R.,
RA   Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F.,
RA   Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G.,
RA   Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D.,
RA   Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D.,
RA   Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C.,
RA   Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D.,
RA   Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- CATALYTIC ACTIVITY: L-homoserine + NAD(P)(+) = L-aspartate 4-
CC       semialdehyde + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC   -!- SIMILARITY: Contains 1 ACT domain.
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DR   EMBL; AE000511; AAD07869.1; -; Genomic_DNA.
DR   PIR; F64622; F64622.
DR   RefSeq; NP_207615.1; -.
DR   DIP; DIP:3530N; -.
DR   GeneID; 898826; -.
DR   GenomeReviews; AE000511_GR; HP_0822.
DR   KEGG; hpy:HP0822; -.
DR   NMPDR; fig|85962.1.peg.813; -.
DR   TIGR; HP_0822; -.
DR   HOGENOM; P56429; -.
DR   InterPro; IPR002912; ACT_bd.
DR   InterPro; IPR005106; Asp/hSer_DHase_NAD-bd.
DR   InterPro; IPR016204; hSer_DHase.
DR   InterPro; IPR001342; hSer_DHase_cat.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   Complete proteome; Isoleucine biosynthesis; Methionine biosynthesis;
KW   NADP; Oxidoreductase; Threonine biosynthesis.
FT   CHAIN         1    421       Homoserine dehydrogenase.
FT                                /FTId=PRO_0000066694.
FT   DOMAIN      342    419       ACT.
FT   NP_BIND      10     17       NADP (By similarity).
FT   ACT_SITE    201    201       Proton donor (Potential).
FT   BINDING     103    103       NADP (By similarity).
FT   BINDING     186    186       Substrate (By similarity).
SQ   SEQUENCE   421 AA;  46168 MW;  1C10A8C37D2C975B CRC64;
     MKKRLNIGLV GLGCVGSAVA KILQENQEII KDRAGVGIGI KKAVVRDVKK HKGYPFEISN
     DLESLIEDEE IDIVVELMGG VEAPYLLAKK TLAKQKAFVT ANKAMLAYHR YELEQTAKNT
     PIGFEASVCG GIPIIKALKD GLSANHILSF KGILNGTSNY ILSQMFKNQA SFKDALKDAQ
     HLGYAELNPE FDIKGIDAAH KLLILASLAY GIDAKLEEIL IEGIEKIEPD DMEFAKEFGY
     SIKLLGIAKK HPDCIELRVH PSMIKNECML SKVDGVMNAI SVIGDKVGET LYYGAGAGGE
     PTASAVISDI IEIARKKSSL MLGFETPQKL PLKPKEEIQC AYYARLLVSD EKGVFSQISA
     ILAQNDISLN NVLQKEILHS NKAKILFSTH TTNEKSMLNA LKELENLQSV LDTPKMIRLE
     N
//