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UniProtKB/Swiss-Prot entry P56178


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DLX5_HUMAN
Primary accession number P56178
Secondary accession number Q9UPL1
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on January 11, 2001 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 79)
Name and origin of the protein
Protein name Homeobox protein DLX-5
Synonyms None
Gene name
Name: DLX5
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature01782; PubMed=12853948 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.;
"The DNA sequence of human chromosome 7.";
Nature 424:157-164(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE OF 137-202.
TISSUE=Embryo;
DOI=10.1073/pnas.91.6.2250; PubMed=7907794 [NCBI, ExPASy, EBI, Israel, Japan]
Simeone A., Acampora D., Pannese M., D'Esposito M., Stornaiuolo A., Gulisano M., Mallamaci A., Kastury K., Druck T., Huebner K., Boncinelli E.;
"Cloning and characterization of two members of the vertebrate Dlx gene family.";
Proc. Natl. Acad. Sci. U.S.A. 91:2250-2254(1994).
[5]
INTERACTION WITH G22P1.
TISSUE=Osteoblast;
DOI=10.1074/jbc.M206482200; PubMed=12145306 [NCBI, ExPASy, EBI, Israel, Japan]
Willis D.M., Loewy A.P., Charlton-Kachigian N., Shao J.-S., Ornitz D.M., Towler D.A.;
"Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex.";
J. Biol. Chem. 277:37280-37291(2002).
[6]
STRUCTURE BY NMR OF 138-194.
RIKEN structural genomics initiative (RSGI);
"The solution structure of the homeobox domain of human homeobox protein DLX-5.";
Submitted (OCT-2006) to the PDB data bank.
Comments
  • SUBUNIT: Interacts with G22P1 (Ku70).
  • SUBCELLULAR LOCATION: Nucleus (Potential).
  • DEVELOPMENTAL STAGE: First expressed in embryos at 8.5-9 days in facial and branchial arch mesenchyme, otic vesicles and frontonasal ectoderm around olfactory placodes, a day later expression is seen in the developing forebrain in primordia of the ganglionic eminence and ventral diencephalic regions. In day 12.5 embryos, expressed in the brain and bones, and also in all skeletal structures of midgestation embryos after the first cartilage formation. Expression remains unaltered in both brain and skeleton in day 15 embryos and slowly decreases in day 17 embryos.
  • SIMILARITY: Belongs to the distal-less homeobox family.
  • SIMILARITY: Contains 1 homeobox DNA-binding domain.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK023493; BAB14587.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC004774; AAC17833.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC006226; AAH06226.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00008192; -.
PIR C53495; C53495.
RefSeq NP_005212.1; -.
UniGene Hs.99348
3D structure databases
PDB
2DJN; NMR; -; A=138-194.[ExPASy / RCSB / EBI]
PDBsum 2DJN; -.
ModBase P56178.
PTM databases
PhosphoSite P56178; -.
Organism-specific databases
GeneCards GC07M096487; -.
H-InvDB HIX0006872; -.
HGNC HGNC:2918; DLX5.
GenAtlas DLX5.
HPA HPA005670; -.
MIM 600028; gene. [NCBI / EBI]
PharmGKB PA27373; -.
Gene expression databases
ArrayExpress P56178; -.
Bgee P56178; -.
CleanEx HS_DLX5; -.
GermOnline ENSG00000105880; Homo sapiens.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from direct assay from HPA).
GO:0043565; Molecular function: sequence-specific DNA binding (inferred from electronic annotation from InterPro).
GO:0003700; Molecular function: transcription factor activity (inferred from electronic annotation from InterPro).
GO:0001501; Biological process: skeletal system development (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR001356; Homeobox.
IPR017970; Homeobox_CS.
IPR012287; Homeodomain-rel.
IPR000047; HTH_lambrepressr.
Graphical view of domain structure.
Gene3D G3DSA:1.10.10.60; Homeodomain-rel; 1.
Pfam PF00046; Homeobox; 1.
Pfam graphical view of domain structure.
PRINTS PR00031; HTHREPRESSR.
ProDom PD000010; Homeobox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00389; HOX; 1.
SMART graphical view of domain structure.
PROSITE PS00027; HOMEOBOX_1; 1.
PS50071; HOMEOBOX_2; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE P56178; -.
Genome annotation databases
Ensembl ENSG00000105880; Homo sapiens. [Contig view]
GeneID 1749; -.
KEGG hsa:1749; -.
Phylogenomic databases
HOGENOM P56178; -.
HOVERGEN P56178; -.
OMA P56178; SPYHQYG.
Other
NextBio 7097; -.
SOURCE DLX5; Homo sapiens.
ProtoNet P56178.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Developmental protein; DNA-binding; Homeobox; Nucleus; Polymorphism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   289  289     Homeobox protein DLX-5. PRO_0000049031
DNA_BIND   137   196  60     Homeobox. 
VARIANT   234   234  1     S -> R (in dbSNP:rs35273378 [NCBI]). VAR_033874 
HELIX   146   156  11      
HELIX   164   173  10      
HELIX   178   190  13      
Sequence information
Length: 289 AA [This is the length of the unprocessed precursor] Molecular weight: 31540 Da [This is the MW of the unprocessed precursor] CRC64: 5BC9970B12E30554 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTGVFDRRVP SIRSGDFQAP FQTSAAMHHP SQESPTLPES SATDSDYYSP TGGAPHGYCS 

        70         80         90        100        110        120 
PTSASYGKAL NPYQYQYHGV NGSAGSYPAK AYADYSYASS YHQYGGAYNR VPSATNQPEK 

       130        140        150        160        170        180 
EVTEPEVRMV NGKPKKVRKP RTIYSSFQLA ALQRRFQKTQ YLALPERAEL AASLGLTQTQ 

       190        200        210        220        230        240 
VKIWFQNKRS KIKKIMKNGE MPPEHSPSSS DPMACNSPQS PAVWEPQGSS RSLSHHPHAH 

       250        260        270        280 
PPTSNQSPAS SYLENSASWY TSAASSINSH LPPPGSLQHP LALASGTLY 

P56178 in FASTA format

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