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UniProtKB/Swiss-Prot entry P55989

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name COPA_HELPY
Primary accession number P55989
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1997 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 64)
Name and origin of the protein
Protein name Copper-transporting ATPase
Synonym EC 3.6.3.4
Gene name
Name: copA
OrderedLocusNames: HP_1072
From
Helicobacter pylori (Campylobacter pylori) [TaxID: 210] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700392 / 26695;
DOI=10.1038/41483; PubMed=9252185 [NCBI, ExPASy, EBI, Israel, Japan]
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
"The complete genome sequence of the gastric pathogen Helicobacter pylori.";
Nature 388:539-547(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000511; AAD08117.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR H64653; H64653.
RefSeq NP_207863.1; -.
3D structure databases
HSSP Q47840; 1CPZ. [HSSP ENTRY / PDB]
ModBase P55989.
Protein-protein interaction databases
DIP DIP:3096N; -.
Family and domain databases
InterPro IPR006416; ATPase-IB_hvy.
IPR001757; ATPase_P.
IPR006403; ATPase_P_cat/Cu.
IPR001756; ATPase_P_Cu.
IPR005834; Dehalogen-like_hydro.
IPR008250; E1-E2_ATPase_reg.
IPR006121; HeavyMe_transpt.
Graphical view of domain structure.
PANTHER PTHR11939; ATPase_P; 1.
Pfam PF00122; E1-E2_ATPase; 1.
PF00403; HMA; 1.
PF00702; Hydrolase; 1.
Pfam graphical view of domain structure.
PRINTS PR00119; CATATPASE.
PR00943; CUATPASE.
TIGRFAMs TIGR01511; ATPase-IB1_Cu; 1.
TIGR01525; ATPase-IB_hvy; 1.
TIGR01494; ATPase_P-type; 2.
PROSITE PS00154; ATPASE_E1_E2; 1.
PS01047; HMA_1; 1.
PS50846; HMA_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P55989.
Genome annotation databases
GeneID 899608; -.
GenomeReviews AE000511_GR; HP_1072.
KEGG hpy:HP1072; -.
NMPDR fig|85962.1.peg.1059; -.
TIGR HP_1072; -.
Phylogenomic databases
HOGENOM P55989; -.
Other
ProtoNet P55989.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell membrane; Complete proteome; Copper; Copper transport; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   745  745     Copper-transporting ATPase. PRO_0000046170
TOPO_DOM   1    83  83     Cytoplasmic (Potential). 
TRANSMEM   84   104  21     Potential. 
TOPO_DOM   105   124  20     Extracellular (Potential). 
TRANSMEM   125   144  20     Potential. 
TOPO_DOM   145   151  7     Cytoplasmic (Potential). 
TRANSMEM   152   172  21     Potential. 
TOPO_DOM   173   194  22     Extracellular (Potential). 
TRANSMEM   195   215  21     Potential. 
TOPO_DOM   216   343  128     Cytoplasmic (Potential). 
TRANSMEM   344   366  23     Potential. 
TOPO_DOM   367   379  13     Extracellular (Potential). 
TRANSMEM   380   397  18     Potential. 
TOPO_DOM   398   685  288     Cytoplasmic (Potential). 
TRANSMEM   686   705  20     Potential. 
TOPO_DOM   706   716  11     Extracellular (Potential). 
TRANSMEM   717   735  19     Potential. 
TOPO_DOM   736   745  10     Cytoplasmic (Potential). 
DOMAIN   2    68  67     HMA. 
ACT_SITE   435   435        4-aspartylphosphate intermediate (By similarity). 
METAL   12    12        Copper (Potential). 
METAL   15    15        Copper (Potential). 
METAL   631   631        Magnesium (By similarity). 
METAL   635   635        Magnesium (By similarity). 
Sequence information
Length: 745 AA [This is the length of the unprocessed precursor] Molecular weight: 81853 Da [This is the MW of the unprocessed precursor] CRC64: 855C10A737C072C9 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKESFYIEGM TCTACSSGIE RSLGRKSFVK KIEVSLLNKS ANIEFDENQT NLDEIFKLIE 

        70         80         90        100        110        120 
KLGYSPKKAL TKEKKEFFSP NVKLALAVIF TLFVVYLSMG AMLSPSLLPE SLLAIDNHSN 

       130        140        150        160        170        180 
FLNACLQLIG ALIVMHLGRD FYIQGFKALW HRQPNMSSLI AIGTSAALIS SLWQLYLVYT 

       190        200        210        220        230        240 
NHYTDQWSYG HYYFESVCVI LMFVMVGKRI ENVSKDKALD AMQALMKNAP KTALKMQNNQ 

       250        260        270        280        290        300 
QIEVLVDSIV VGDILKVLPG SAIAVDGEII EGEGELDESM LSGEALPVYK KVGDKVFSGT 

       310        320        330        340        350        360 
FNSHTSFLMK ATQNNKNSTL SQIIEMIYNA QSSKAEISRL ADKVSSVFVP SVIAISILAF 

       370        380        390        400        410        420 
VVWLIIAPKP DFWWNFGIAL EVFVSVLVIS CPCALGLATP MSILVANQKA SSLGLFFKDA 

       430        440        450        460        470        480 
KSLEKARLVN TIVFDKTGTL TNGKPVVKSV HSKIELLELL SLALSIEKSS EHVIAKGIVE 

       490        500        510        520        530        540 
YAKEHNAPLK EMSGVKVKTG FGISAKTDYQ GTKEIIKVGN SEFFNPINTL EIKENGILVF 

       550        560        570        580        590        600 
VGRAISEKED ELLGAFVLED LPKKGVKEHI AQIKNLGINT FLLSGDNREN VQKCAFELGI 

       610        620        630        640        650        660 
DGYISNAKPQ DKLNKIKELK EKGQIVMMVG DGLNDAPSLA MSDVAVVMAK GSDVSVQAAD 

       670        680        690        700        710        720 
IVSFNNDIKS VYSAIKLSQA TIKNIKENLF WAFCYNSVFI PLACGVLYKA NLMLSPAIAG 

       730        740 
LAMSLSSVSV VLNSQRLRNF KIKDH
P55989 in FASTA format

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