[1]
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NUCLEOTIDE SEQUENCE (ISOFORM 1).
PubMed=8918887 [NCBI, ExPASy, EBI, Israel, Japan]
Wang K.,
Yin X.-M.,
Chao D.T.,
Milliman C.L.,
Korsmeyer S.J.;
"BID: a novel BH3 domain-only death agonist.";
Genes Dev. 10:2859-2869(1996).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
DOI=10.1006/geno.1998.5392; PubMed=9721221 [NCBI, ExPASy, EBI, Israel, Japan]
Footz T.K.,
Birren B.,
Minoshima S.,
Asakawa S.,
Shimizu N.,
Riazi M.A.,
McDermid H.E.;
"The gene for death agonist BID maps to the region of human 22q11.2 duplicated in cat eye syndrome chromosomes and to mouse chromosome 6.";
Genomics 51:472-475(1998).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND FUNCTION.
DOI=10.1074/jbc.M309769200; PubMed=14583606 [NCBI, ExPASy, EBI, Israel, Japan]
Renshaw S.A.,
Dempsey C.E.,
Barnes F.A.,
Bagstaff S.M.,
Dower S.K.,
Bingle C.D.,
Whyte M.K.;
"Three novel Bid proteins generated by alternative splicing of the human Bid gene.";
J. Biol. Chem. 279:2846-2855(2004).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Dai F.Y.,
Yu L.,
Huang H.B.,
Jiang C.L.,
Cui Y.Y.,
Zhao S.Y.;
"Cloning and expression of a new human cDNA homology to murine apoptic death agonist (BID) mRNA.";
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
DOI=10.1186/gb-2004-5-10-r84; PubMed=15461802 [NCBI, ExPASy, EBI, Israel, Japan]
Collins J.E.,
Wright C.L.,
Edwards C.A.,
Davis M.P.,
Grinham J.A.,
Cole C.G.,
Goward M.E.,
Aguado B.,
Mallya M.,
Mokrab Y.,
Huckle E.J.,
Beare D.M.,
Dunham I.;
"A genome annotation-driven approach to cloning the human ORFeome.";
Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Ebert L.,
Schick M.,
Neubert P.,
Schatten R.,
Henze S.,
Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
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[7]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLY-10.
NIEHS SNPs program;
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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[8]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT GLN-162.
TISSUE=Brain, and Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[9]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-54, AND MASS SPECTROMETRY.
DOI=10.1038/nbt1046; PubMed=15592455 [NCBI, ExPASy, EBI, Israel, Japan]
Rush J.,
Moritz A.,
Lee K.A.,
Guo A.,
Goss V.L.,
Spek E.J.,
Zhang H.,
Zha X.-M.,
Polakiewicz R.D.,
Comb M.J.;
"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.";
Nat. Biotechnol. 23:94-101(2005).
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[10]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78, AND MASS SPECTROMETRY.
DOI=10.1126/science.1140321; PubMed=17525332 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuoka S.,
Ballif B.A.,
Smogorzewska A.,
McDonald E.R. III,
Hurov K.E.,
Luo J.,
Bakalarski C.E.,
Zhao Z.,
Solimini N.,
Lerenthal Y.,
Shiloh Y.,
Gygi S.P.,
Elledge S.J.;
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.";
Science 316:1160-1166(2007).
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[11]
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IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J.,
Superti-Furga G.,
Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
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[12]
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STRUCTURE BY NMR.
DOI=10.1016/S0092-8674(00)80572-3; PubMed=10089877 [NCBI, ExPASy, EBI, Israel, Japan]
Chou J.J.,
Li H.,
Salvesen G.S.,
Yuan J.,
Wagner G.;
"Solution structure of BID, an intracellular amplifier of apoptotic signaling.";
Cell 96:615-624(1999).
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- FUNCTION: The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.
- SUBUNIT: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2 (By similarity).
- INTERACTION:
Q16611:BAK1; NbExp=1; IntAct=EBI-519672, EBI-519866;
P10415:BCL2; NbExp=3; IntAct=EBI-519672, EBI-77694;
Q16548:BCL2A1; NbExp=1; IntAct=EBI-519672, EBI-1003550;
Q07440:Bcl2a1 (xeno); NbExp=1; IntAct=EBI-519672, EBI-707754;
Q07817:BCL2L1; NbExp=1; IntAct=EBI-519672, EBI-78035;
Q07817-1:BCL2L1; NbExp=1; IntAct=EBI-519672, EBI-287195;
Q92843:BCL2L2; NbExp=2; IntAct=EBI-519672, EBI-707714;
Q07820:MCL1; NbExp=1; IntAct=EBI-519672, EBI-1003422;
- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Mitochondrion membrane (By similarity). Note=When uncleaved, it is predominantly cytoplasmic.
- SUBCELLULAR LOCATION: BH3-interacting domain death agonist p15: Mitochondrion membrane (By similarity). Note=Translocates to mitochondria as an integral membrane protein (By similarity).
- SUBCELLULAR LOCATION: BH3-interacting domain death agonist p13: Mitochondrion membrane (By similarity). Note=Associated with the mitochondrial membrane (By similarity).
- SUBCELLULAR LOCATION: Isoform 1: Cytoplasm.
- SUBCELLULAR LOCATION: Isoform 3: Cytoplasm.
- SUBCELLULAR LOCATION: Isoform 2: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively.
- ALTERNATIVE PRODUCTS:
4 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Synonyms | BID(EL) |
| Isoform ID | P55957-2 |
| Features which should be applied to build the isoform sequence: VSP_017267. |
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| Name | 4 |
| Synonyms | BID(ES) |
| Isoform ID | P55957-4 |
| Features which should be applied to build the isoform sequence: VSP_017266. |
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- TISSUE SPECIFICITY: Isoforms 2 and 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).
- DOMAIN: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
- PTM: TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products (By similarity).
- PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
- WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/bid/";.
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