ID   CXA8_SHEEP              Reviewed;         440 AA.
AC   P55917; Q9MYL3;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   22-JUL-2008, entry version 52.
DE   RecName: Full=Gap junction alpha-8 protein;
DE   AltName: Full=Connexin-49;
DE            Short=Cx49;
DE   AltName: Full=Lens fiber protein MP70;
DE   AltName: Full=MP64;
DE   AltName: Full=MP38;
GN   Name=GJA8;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=96254875; PubMed=8654111;
RA   Yang D.-I., Louis C.F.;
RT   "Molecular cloning of sheep connexin49 and its identity with MP70.";
RL   Curr. Eye Res. 15:307-314(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Yang D.-I., Louis C.F.;
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PROTEIN SEQUENCE OF 2-21.
RC   TISSUE=Lens;
RX   MEDLINE=88143159; PubMed=2830542; DOI=10.1038/331721a0;
RA   Kistler J., Christie D., Bullivant S.;
RT   "Homologies between gap junction proteins in lens, heart and liver.";
RL   Nature 331:721-723(1988).
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which
CC       materials of low MW diffuse from one cell to a neighboring cell.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC       Cell junction, gap junction.
CC   -!- TISSUE SPECIFICITY: Eye lens.
CC   -!- SIMILARITY: Belongs to the connexin family. Alpha-type (group II)
CC       subfamily.
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DR   EMBL; AF177913; AAF01367.1; -; Genomic_DNA.
DR   HOVERGEN; P55917; -.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR013125; Connexin50_C.
DR   InterPro; IPR013092; Connexin_N.
DR   PANTHER; PTHR11984; Connexin; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   Pfam; PF03509; Connexin50; 1.
DR   SMART; SM00037; CNX; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   1: Evidence at protein level;
KW   Cell junction; Cell membrane; Direct protein sequencing; Gap junction;
KW   Membrane; Transmembrane.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    440       Gap junction alpha-8 protein.
FT                                /FTId=PRO_0000057832.
FT   TOPO_DOM      2     23       Cytoplasmic (Potential).
FT   TRANSMEM     24     46       Potential.
FT   TOPO_DOM     47     74       Extracellular (Potential).
FT   TRANSMEM     75     97       Potential.
FT   TOPO_DOM     98    157       Cytoplasmic (Potential).
FT   TRANSMEM    158    180       Potential.
FT   TOPO_DOM    181    209       Extracellular (Potential).
FT   TRANSMEM    210    229       Potential.
FT   TOPO_DOM    230    440       Cytoplasmic (Potential).
FT   VARIANT       9      9       N -> R.
FT   VARIANT      10     10       I -> L.
FT   VARIANT      14     14       V -> A.
FT   CONFLICT     13     13       E -> N (in Ref. 3; AA sequence).
FT   CONFLICT     15     15       N -> Q (in Ref. 3; AA sequence).
FT   CONFLICT     42     42       E -> D (in Ref. 2; AAF01367).
SQ   SEQUENCE   440 AA;  49160 MW;  BE6E478B98D83891 CRC64;
     MGDWSFLGNI LEEVNEHSTV IGRVWLTVLF IFRILILGTA AEFVWGDEQS DFVCNTQQPG
     CENVCYDEAF PISHIRLWVL QIIFVSTPSL VYVGHAVHHV RMEEKRKERE AEELSQQSPG
     NGGERAPLAA DQGSVKKSSS SSKGTKKFRL EGTLLRTYVC HIIFKTLFEV GFIVGHYFLY
     GFRILPLYRC SRWPCPNVVD CFVSRPTEKT IFILFMLSVA SVSLFLNILE MSHLGLKKIR
     SAFKRPVEQP LGEIPEKSLH SIAVSSIQKA KGYQLLEEEK IVSHYFPLTE VGMVEASPLS
     AKPFSQFEEK VGPGPLGDLS RAYQETLPSY AQVGAQEGVE EEQPIEAAAE PEVGDKSQEA
     ERVSTEGEET LAVLEEEKVE PPEVEKEAEK EETPPEKVSK QELTPEKAPS LCAELPGEDT
     RPLSRLSKAS SRARSDDLTV
//