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UniProtKB/Swiss-Prot entry P54922

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADPRH_HUMAN
Primary accession number P54922
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 69)
Name and origin of the protein
Protein name [Protein ADP-ribosylarginine] hydrolase
Synonyms ADP-ribosylarginine hydrolase
EC 3.2.2.19
ADP-ribose-L-arginine cleaving enzyme
Gene name
Name: ADPRH
Synonyms: ARH1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8349667 [NCBI, ExPASy, EBI, Israel, Japan]
Takada T., Iida K., Moss J.;
"Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase.";
J. Biol. Chem. 268:17837-17843(1993).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L13291; AAA35555.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC063883; AAH63883.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC074769; AAH74769.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00009258; -.
PIR B47411; B47411.
RefSeq NP_001116.1; -.
UniGene Hs.99884
3D structure databases
ModBase P54922.
PTM databases
PhosphoSite P54922; -.
Enzyme and pathway databases
BRENDA 3.2.2.19; 247.
2D gel databases
OGP P54922; -.
Organism-specific databases
GeneCards GC03P120781; -.
H-InvDB HIX0030805; -.
HGNC HGNC:269; ADPRH.
GenAtlas ADPRH.
HPA CAB001701; -.
MIM 603081; gene. [NCBI / EBI]
PharmGKB PA24590; -.
Gene expression databases
ArrayExpress P54922; -.
Bgee P54922; -.
CleanEx HS_ADPRH; -.
GermOnline ENSG00000144843; Homo sapiens.
Ontologies
GO
GO:0003875; Molecular function: ADP-ribosylarginine hydrolase activity (inferred from mutant phenotype from UniProtKB).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0051725; Biological process: protein amino acid de-ADP-ribosylation (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR012108; ADP-ribosylarg_hydro.
IPR005502; Ribosyl_crysJ1.
Graphical view of domain structure.
PANTHER PTHR22957:SF7; ADP-ribosylarg_hydro; 1.
Pfam PF03747; ADP_ribosyl_GH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF016939; ADP_ribslarg_hdr; 1.
Proteomic databases
PRIDE P54922; -.
Genome annotation databases
Ensembl ENSG00000144843; Homo sapiens. [Contig view]
GeneID 141; -.
KEGG hsa:141; -.
Phylogenomic databases
HOGENOM P54922; -.
HOVERGEN P54922; -.
OMA P54922; IPFNSHE.
Other
NextBio 561; -.
SOURCE ADPRH; Homo sapiens.
ProtoNet P54922.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Hydrolase; Magnesium.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   357  357     [Protein ADP-ribosylarginine] hydrolase. PRO_0000157283
Sequence information
Length: 357 AA [This is the length of the unprocessed precursor] Molecular weight: 39507 Da [This is the MW of the unprocessed precursor] CRC64: 4E23B12FAE84F12B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEKYVAAMVL SAAGDALGYY NGKWEFLQDG EKIHRQLAQL GGLDALDVGR WRVSDDTVMH 

        70         80         90        100        110        120 
LATAEALVEA GKAPKLTQLY YLLAKHYQDC MEDMDGRAPG GASVHNAMQL KPGKPNGWRI 

       130        140        150        160        170        180 
PFNSHEGGCG AAMRAMCIGL RFPHHSQLDT LIQVSIESGR MTHHHPTGYL GALASALFTA 

       190        200        210        220        230        240 
YAVNSRPPLQ WGKGLMELLP EAKKYIVQSG YFVEENLQHW SYFQTKWENY LKLRGILDGE 

       250        260        270        280        290        300 
SAPTFPESFG VKERDQFYTS LSYSGWGGSS GHDAPMIAYD AVLAAGDSWK ELAHRAFFHG 

       310        320        330        340        350 
GDSDSTAAIA GCWWGVMYGF KGVSPSNYEK LEYRNRLEET ARALYSLGSK EDTVISL
P54922 in FASTA format

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