[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1038/ng0492-34; PubMed=1301997 [NCBI, ExPASy, EBI, Israel, Japan] Martin-Gallardo A., McCombie W.R., Gocayne J.D., Fitzgerald M.G., Wallace S., Lee B.M., Lamerdin J.E., Trapp S., Kelley J.M., Liu L.-I., Dubnick M., Johnston-Dow L.A., Kerlavage A.R., de Jong P., Carrano A., Fields C., Venter J.C.; "Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3."; Nat. Genet. 1:34-39(1992).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Blood; DOI=10.1089/dna.1996.15.1025; PubMed=8985116 [NCBI, ExPASy, EBI, Israel, Japan] Heximer S.P., Cristillo A.D., Russell L., Forsdyke D.R.; "Sequence analysis and expression in cultured lymphocytes of the human FOSB gene (G0S3)."; DNA Cell Biol. 15:1025-1038(1996).
[3]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT SER-33. NIEHS SNPs program; Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
[4]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Blood; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: FosB interacts with Jun proteins enhancing their DNA binding activity.
SUBUNIT: Heterodimer (By similarity).
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Belongs to the bZIP family. Fos subfamily.
SIMILARITY: Contains 1 bZIP domain.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fosb/";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L49169; AAB53946.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY898963; AAW65374.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC036724; AAH36724.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00295556; -.

I53043; I53043.

NP_006723.2; -.

3D structure databases

HSSP

P01100; 1FOS. [HSSP ENTRY / PDB]

P53539; 157-215.

PTM databases

P53539; -.

Organism-specific databases

GC19P050663; -.

HGNC:3797; FOSB.

CAB010267; -.

164772; gene. [NCBI / EBI]

PharmGKB

PA28213; -.

Gene expression databases

P53539; -.

P53539; -.

HS_FOSB; -.

ENSG00000125740; Homo sapiens.

Ontologies

GO:0005634;	Cellular component: nucleus (inferred from electronic annotation from UniProtKB-SubCell).
GO:0046983;	Molecular function: protein dimerization activity (inferred from electronic annotation from InterPro).
GO:0043565;	Molecular function: sequence-specific DNA binding (inferred from electronic annotation from InterPro).
GO:0003700;	Molecular function: transcription factor activity (inferred from electronic annotation from InterPro).
GO:0008134;	Molecular function: transcription factor binding (traceable author statement from ProtInc).
GO:0007610;	Biological process: behavior (traceable author statement from ProtInc).
GO:0007275;	Biological process: multicellular organismal development (traceable author statement from ProtInc).
GO:0000122;	Biological process: negative regulation of transcription from RNA polymerase II promoter (traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR011616; bZIP_1.
IPR000837; Leuzip_Fos.
IPR004827; TF_bZIP.
Graphical view of domain structure.

Pfam

PF00170; bZIP_1; 1.
Pfam graphical view of domain structure.

PRINTS

PR00042; LEUZIPPRFOS.

SMART

SM00338; BRLZ; 1.
SMART graphical view of domain structure.

PROSITE

PS50217; BZIP; 1.
PS00036; BZIP_BASIC; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

ENSG00000125740; Homo sapiens. [Contig view]

GeneID

2354; -.

Phylogenomic databases

HOGENOM

P53539; -.

HOVERGEN

P53539; -.

OMA

P53539; KEDGFGW.

Other

9547; -.

FOSB; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

DNA-binding; Nucleus; Polymorphism.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 338`	`338`	`Protein fosB.`	`PRO_0000076476`
`DOMAIN`	`183 211`	`29`	`Leucine-zipper.`
`DNA_BIND`	`161 179`	`19`	`Basic motif.`
`VARIANT`	`33 33`	`1`	`G -> S.`	`VAR_022286`
`CONFLICT`	`338 338`		`L -> R (in Ref. 2; AAB53946).`

Sequence information

Length: 338 AA [This is the length of the unprocessed precursor]

Molecular weight: 35928 Da [This is the MW of the unprocessed precursor]

CRC64: DDFF827C5047850F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM PGSFVPTVTA 

        70         80         90        100        110        120 
ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP GTSYSTPGMS GYSSGGASGS 

       130        140        150        160        170        180 
GGPSTSGTTS GPGPARPARA RPRRPREETL TPEEEEKRRV RRERNKLAAA KCRNRRRELT 

       190        200        210        220        230        240 
DRLQAETDQL EEEKAELESE IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD 

       250        260        270        280        290        300 
LPGSAPAKED GFSWLLPPPP PPPLPFQTSQ DAPPNLTASL FTHSEVQVLG DPFPVVNPSY 

       310        320        330 
TSSFVLTCPE VSAFAGAQRT SGSDQPSDPL NSPSLLAL

P53539 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools