NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).

Comments

FUNCTION: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity).
CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
PATHWAY: Protein modification; protein ubiquitination .
SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
SIMILARITY: Contains 1 UBA domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U39674; AAA80415.2; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

T15432; T15432.

NP_509502.2; -.

3D structure databases

HSSP

P21734; 1FZY. [HSSP ENTRY / PDB]

ModBase

P52484.

Organism-specific databases

WormBase

WBGene00006716; ubc-21.

WormPep

C06E2.3; CE40013. [WormPep / WorfDB]

Gene expression databases

ArrayExpress

P52484; -.

Family and domain databases

InterPro

IPR015940; UBA/transl_elong_EF1B_N_euk.
IPR016135; UBQ-conjugat/RWD-like.
IPR000608; UBQ-conjugat_E2.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.110.10; UBQ-conjugat_E2; 1.

PANTHER

PTHR11621; UBQ-conjugat_E2; 1.

Pfam

PF00179; UQ_con; 1.
Pfam graphical view of domain structure.

ProDom

PD000461; UBQ_conjugat; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00212; UBCc; 1.
SMART graphical view of domain structure.

PROSITE

PS50030; UBA; 1.
PS00183; UBIQUITIN_CONJUGAT_1; 1.
PS50127; UBIQUITIN_CONJUGAT_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

P52484.

Genome annotation databases

Ensembl

C06E2.3; Caenorhabditis elegans. [Contig view]

GeneID

182321; -.

KEGG

cel:C06E2.3; -.

Other

ProtoNet

P52484.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Ligase; Ubl conjugation pathway.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 229`	`229`	`Probable ubiquitin-conjugating enzyme E2 21.`	`PRO_0000082518`
`DOMAIN`	`187 229`	`43`	`UBA.`
`ACT_SITE`	`121 121`		`Glycyl thioester intermediate (By similarity).`

Sequence information

Length: 229 AA [This is the length of the unprocessed precursor]

Molecular weight: 26065 Da [This is the MW of the unprocessed precursor]

CRC64: 7FBE05784F66386C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSVSKLNKMQ FSDKMSNLAL ARVTRKCKEV ANASDITEAG IHVEIKENNL MDIKGFIKGP 

        70         80         90        100        110        120 
EGTPYAGGTF EIKVDIPEHY PFEPPKVTEI IFHIRAFEYI QAKFVTRIWH PNISSQTGTI 

       130        140        150        160        170        180 
CLDILKDKWT ASLTLRTVLL SLQAMLCSPE PSDPQDAVVA KQFINNYPMF TATAVYWTSY 

       190        200        210        220 
FANSKKDVEP DFNRKVGRLI EMGIRETEAI VYLSCNNWKL EQALQFIFD

P52484 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools