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UniProtKB/Swiss-Prot entry P52209

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name 6PGD_HUMAN
Primary accession number P52209
Secondary accession number Q9BWD8
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    July 22, 2008 (Entry version 80)
Name and origin of the protein
Protein name 6-phosphogluconate dehydrogenase, decarboxylating
Synonym EC 1.1.1.44
Gene name
Name: PGD
Synonyms: PGDH
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Heart;
DOI=10.1007/BF00554412; PubMed=8978909 [NCBI, ExPASy, EBI, Israel, Japan]
Tsui S.K.W., Chan J.Y., Waye M.M.Y., Fung K.-P., Lee C.-Y.;
"Identification of a cDNA encoding 6-phosphogluconate dehydrogenase from a human heart cDNA library.";
Biochem. Genet. 34:367-373(1996).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U30255; AAA75302.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000368; AAH00368.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR G01922; G01922.
RefSeq NP_002622.2; -.
UniGene Hs.464071
3D structure databases
HSSP P00349; 2PGD. [HSSP ENTRY / PDB]
SMR P52209; 2-474.
ModBase P52209.
Protein-protein interaction databases
IntAct P52209; -.
PTM databases
PhosphoSite P52209; -.
Enzyme and pathway databases
Reactome REACT_1709; Metabolism of small molecules.
Organism-specific databases
H-InvDB HIX0000112; -.
HGNC HGNC:8891; PGD.
GenAtlas PGD.
MIM 172200; gene. [NCBI / EBI]
PharmGKB PA29424; -.
GeneCards P52209.
Gene expression databases
ArrayExpress P52209; -.
CleanEx HS_PGD; -.
GermOnline ENSG00000142657; Homo sapiens.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0055114; Biological process: oxidation reduction (inferred from direct assay from UniProtKB).
GO:0009051; Biological process: pentose-phosphate shunt, oxidative branch (inferred from direct assay from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR006183; 6-phosphogluconate_DHase.
IPR006114; 6PGDH_C.
IPR006113; 6PGDH_decarbox.
IPR006115; 6PGDH_NAD-bd.
IPR006184; 6PGdom_BS.
IPR013328; DHase_multihelical.
IPR012284; Fibritin/6PGD_C-extension.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:1.20.5.320; Fibritin/6PGD_C-extension; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
Pfam PF00393; 6PGD; 1.
PF03446; NAD_binding_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00076; 6PGDHDRGNASE.
TIGRFAMs TIGR00873; gnd; 1.
PROSITE PS00461; 6PGD; 1.
BLOCKS P52209.
Proteomic databases
PeptideAtlas P52209; -.
Genome annotation databases
Ensembl ENSG00000142657; Homo sapiens. [Contig view]
GeneID 5226; -.
KEGG hsa:5226; -.
Phylogenomic databases
HOVERGEN P52209; -.
Other
LinkHub P52209; -.
SOURCE PGD; Homo sapiens.
ProtoNet P52209.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
NADP; Oxidoreductase; Pentose shunt.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   483  482     6-phosphogluconate dehydrogenase, decarboxylating. PRO_0000090063
CONFLICT   118   118        A -> G (in Ref. 1; AAA75302). 
CONFLICT   135   135        A -> P (in Ref. 1; AAA75302). 
Sequence information
Length: 483 AA [This is the length of the unprocessed precursor] Molecular weight: 53140 Da [This is the MW of the unprocessed precursor] CRC64: 6CEFC0077D1283E3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAQADIALIG LAVMGQNLIL NMNDHGFVVC AFNRTVSKVD DFLANEAKGT KVVGAQSLKE 

        70         80         90        100        110        120 
MVSKLKKPRR IILLVKAGQA VDDFIEKLVP LLDTGDIIID GGNSEYRDTT RRCRDLKAKG 

       130        140        150        160        170        180 
ILFVGSGVSG GEEGARYGPS LMPGGNKEAW PHIKTIFQGI AAKVGTGEPC CDWVGDEGAG 

       190        200        210        220        230        240 
HFVKMVHNGI EYGDMQLICE AYHLMKDVLG MAQDEMAQAF EDWNKTELDS FLIEITANIL 

       250        260        270        280        290        300 
KFQDTDGKHL LPKIRDSAGQ KGTGKWTAIS ALEYGVPVTL IGEAVFARCL SSLKDERIQA 

       310        320        330        340        350        360 
SKKLKGPQKF QFDGDKKSFL EDIRKALYAS KIISYAQGFM LLRQAATEFG WTLNYGGIAL 

       370        380        390        400        410        420 
MWRGGCIIRS VFLGKIKDAF DRNPELQNLL LDDFFKSAVE NCQDSWRRAV STGVQAGIPM 

       430        440        450        460        470        480 
PCFTTALSFY DGYRHEMLPA SLIQAQRDYF GAHTYELLAK PGQFIHTNWT GHGGTVSSSS 


YNA
P52209 in FASTA format

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