[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=BGSC5A2; DOI=10.1093/dnares/1.4.157; PubMed=8535972 [NCBI, ExPASy, EBI, Israel, Japan] Yoshida K., Seki S., Fujita Y.; "Nucleotide sequence and features of the Bacillus licheniformis gnt operon."; DNA Res. 1:157-162(1994).

Comments

CATALYTIC ACTIVITY: 6-phospho-D-gluconate + NADP⁺ = D-ribulose 5-phosphate + CO₂ + NADPH.
PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3 .
SIMILARITY: Belongs to the 6-phosphogluconate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

D31631; BAA06504.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

JC2306; JC2306.

3D structure databases

HSSP

P00349; 2PGD. [HSSP ENTRY / PDB]

ModBase

P52207.

Family and domain databases

InterPro

IPR006183; 6-phosphogluconate_DHase.
IPR006114; 6PGDH_C.
IPR006113; 6PGDH_decarbox.
IPR006115; 6PGDH_NAD-bd.
IPR006184; 6PGdom_BS.
IPR013328; DHase_multihelical.
IPR012284; Fibritin/6PGD_C-extension.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:1.20.5.320; Fibritin/6PGD_C-extension; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.

Pfam

PF00393; 6PGD; 1.
PF03446; NAD_binding_2; 1.
Pfam graphical view of domain structure.

PRINTS

PR00076; 6PGDHDRGNASE.

TIGR00873; gnd; 1.

PS00461; 6PGD; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Gluconate utilization; NADP; Oxidoreductase; Pentose shunt.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 467`	`467`		`6-phosphogluconate dehydrogenase, decarboxylating.`	`PRO_0000090025`

Sequence information

Length: 467 AA [This is the length of the unprocessed precursor]

Molecular weight: 51642 Da [This is the MW of the unprocessed precursor]

CRC64: 3F14CFF0320D8E52 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MRNTIGVIGL GVMGSNIALN MASKGEQVAV YNYTRDLTDQ LVQKTGGQTV KPYYELEDFV 

        70         80         90        100        110        120 
QSLEKPRKIF LMVTAGKPVD SVIDSLVPLL EEGDVIMDGG NSHYEDTERR YDSLKAKGIG 

       130        140        150        160        170        180 
YLGIGISGGE VGALKGPSIM PGGDRDVYEK AAPILTKIAA QVEGDPCCVY IGPKGAGHFV 

       190        200        210        220        230        240 
KMVHNGIEYA DMQLIAEAYT FLREKLLLPI DEIADIFDTW NQGELKSYLI EITAEILRKK 

       250        260        270        280        290        300 
DERTGAPLID VILDKTGQKG TGKWTSLQAI DNGIPSSIIT ESLFARYLSS LKDERTAAEN 

       310        320        330        340        350        360 
VLAGPETEER PLDQNVWIDR VRQALYMGKV CAYAQGFAQY KMTSDLNGWH LPLKDIALIF 

       370        380        390        400        410        420 
RGGCIIRAQF LNLISEVYDK QPDLSNLLVA PDFAEKLKEY QSGLRKVVCE GISSGISFPC 

       430        440        450        460 
LSTALSYYDG YRTGRSNANL LQAQANYFGA HTYERTDMEG VFHTDWY

P52207 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools