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UniProtKB/Swiss-Prot entry P52181

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TGM2_PAGMA
Primary accession number P52181
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 63)
Name and origin of the protein
Protein name Protein-glutamine gamma-glutamyltransferase 2
Synonyms EC 2.3.2.13
Tissue transglutaminase
TGase C
TGC
TG(C)
Transglutaminase-2
Gene name
Name: tgl2
From
Pagrus major (Red sea bream) (Chrysophrys major) [TaxID: 143350] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Percoidei; Sparidae; Pagrus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
TISSUE=Liver;
PubMed=7556189 [NCBI, ExPASy, EBI, Israel, Japan]
Yasueda H., Nakanishi K., Kumazawa Y., Nagase K., Motoki M., Matsui H.;
"Tissue-type transglutaminase from red sea bream (Pagrus major). Sequence analysis of the cDNA and functional expression in Escherichia coli.";
Eur. J. Biochem. 232:411-419(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
S79761; AAB35370.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S66662; S66662.
3D structure databases
PDB
1G0D; X-ray; 2.50 A; A=1-695.[ExPASy / RCSB / EBI]
PDBsum 1G0D; -.
ModBase P52181.
Family and domain databases
InterPro IPR008957; Fibronectin_typ-III-like_fold.
IPR013783; Ig-like_fold.
IPR008958; Transglutaminase_C.
IPR013808; Transglutaminase_CS.
IPR001102; Transglutaminase_N.
IPR002931; Trnsglumase_like.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.30; FN_III-like; 1.
G3DSA:2.60.40.10; Ig-like_fold; 1.
Pfam PF00927; Transglut_C; 2.
PF01841; Transglut_core; 1.
PF00868; Transglut_N; 1.
Pfam graphical view of domain structure.
SMART SM00460; TGc; 1.
SMART graphical view of domain structure.
PROSITE PS00547; TRANSGLUTAMINASES; 1.
BLOCKS P52181.
Phylogenomic databases
HOVERGEN P52181; -.
Other
ProtoNet P52181.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Acyltransferase; Calcium; Direct protein sequencing; Metal-binding; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   695  695     Protein-glutamine gamma-glutamyltransferase 2. PRO_0000213710
ACT_SITE   272   272        By similarity. 
ACT_SITE   332   332        By similarity. 
ACT_SITE   355   355        By similarity. 
METAL   395   395        Calcium (By similarity). 
METAL   397   397        Calcium (By similarity). 
METAL   444   444        Calcium (By similarity). 
METAL   449   449        Calcium (By similarity). 
STRAND   8    12  5      
HELIX   15    21  7      
TURN   25    27  3      
STRAND   29    31  3      
STRAND   33    35  3      
STRAND   40    48  9      
STRAND   55    63  9      
STRAND   67    76  10      
STRAND   79    81  3      
STRAND   83    88  6      
STRAND   90    98  9      
STRAND   106   115  10      
STRAND   121   124  4      
STRAND   128   133  6      
HELIX   148   154  7      
STRAND   159   166  8      
STRAND   169   176  8      
HELIX   184   193  10      
HELIX   196   200  5      
HELIX   202   208  7      
HELIX   212   223  12      
TURN   227   229  3      
STRAND   231   234  4      
HELIX   246   248  3      
STRAND   250   252  3      
HELIX   253   261  9      
STRAND   267   270  4      
HELIX   272   286  15      
STRAND   290   298  9      
TURN   301   304  4      
STRAND   306   312  7      
STRAND   327   339  13      
STRAND   350   355  6      
TURN   363   365  3      
STRAND   368   372  5      
HELIX   373   378  6      
TURN   384   386  3      
HELIX   387   395  9      
STRAND   397   403  7      
STRAND   409   411  3      
STRAND   413   416  4      
STRAND   424   426  3      
STRAND   428   431  4      
STRAND   433   435  3      
HELIX   437   440  4      
HELIX   447   456  10      
STRAND   473   478  6      
STRAND   488   496  9      
STRAND   498   500  3      
STRAND   502   513  12      
STRAND   525   532  8      
STRAND   536   544  9      
HELIX   546   549  4      
TURN   550   552  3      
STRAND   558   566  9      
STRAND   573   581  9      
STRAND   588   590  3      
STRAND   601   608  8      
STRAND   611   613  3      
STRAND   615   617  3      
STRAND   619   624  6      
TURN   625   627  3      
STRAND   628   634  7      
STRAND   636   639  4      
STRAND   644   651  8      
STRAND   657   666  10      
STRAND   673   682  10      
Sequence information
Length: 695 AA [This is the length of the unprocessed precursor] Molecular weight: 78216 Da [This is the MW of the unprocessed precursor] CRC64: A9A128345D474CF8 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MASYKGLIVD VNGRSHENNL AHRTREIDRE RLIVRRGQPF SITLQCSDSL PPKHHLELVL 

        70         80         90        100        110        120 
HLGKRDEVVI KVQKEHGARD KWWFNQQGAQ DEILLTLHSP ANAVIGHYRL AVLVMSPDGH 

       130        140        150        160        170        180 
IVERADKISF HMLFNPWCRD DMVYLPDESK LQEYVMNEDG VIYMGTWDYI RSIPWNYGQF 

       190        200        210        220        230        240 
EDYVMDICFE VLDNSPAALK NSEMDIEHRS DPVYVGRTIT AMVNSNGDRG VLTGRWEEPY 

       250        260        270        280        290        300 
TDGVAPYRWT GSVPILQQWS KAGVRPVKYG QCWVFAAVAC TVLRCLGIPT RPITNFASAH 

       310        320        330        340        350        360 
DVDGNLSVDF LLNERLESLD SRQRSDSSWN FHCWVESWMS REDLPEGNDG WQVLDPTPQE 

       370        380        390        400        410        420 
LSDGEFCCGP CPVAAIKEGN LGVKYDAPFV FAEVNADTIY WIVQKDGQRR KITEDHASVG 

       430        440        450        460        470        480 
KNISTKSVYG NHREDVTLHY KYPEGSQKER EVYKKAGRRV TEPSNEIAEQ GRLQLSIKHA 

       490        500        510        520        530        540 
QPVFGTDFDV IVEVKNEGGR DAHAQLTMLA MAVTYNSLRR GECQRKTISV TVPAHKAHKE 

       550        560        570        580        590        600 
VMRLHYDDYV RCVSEHHLIR VKALLDAPGE NGPIMTVANI PLSTPELLVQ VPGKAVVWEP 

       610        620        630        640        650        660 
LTAYVSFTNP LPVPLKGGVF TLEGAGLLSA TQIHVNGAVA PSGKVSVKLS FSPMRTGVRK 

       670        680        690 
LLVDFDSDRL KDVKGVTTVV VHKKYRSLIT GLHTD
P52181 in FASTA format

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