[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND TISSUE SPECIFICITY.
DOI=10.1021/bi952950g; PubMed=8639485 [NCBI, ExPASy, EBI, Israel, Japan]
Samson M.,
Labbe O.,
Mollereau C.,
Vassart G.,
Parmentier M.;
"Molecular cloning and functional expression of a new human CC-chemokine receptor gene.";
Biochemistry 35:3362-3367(1996).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CCL4 AND CCL5, AND TISSUE SPECIFICITY.
TISSUE=Macrophage;
DOI=10.1074/jbc.271.29.17161; PubMed=8663314 [NCBI, ExPASy, EBI, Israel, Japan]
Raport C.J.,
Gosling J.,
Schweichart V.L.,
Gray P.W.,
Charo I.F.;
"Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha.";
J. Biol. Chem. 271:17161-17166(1996).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INTERACTION WITH CCL3; CCL4 AND CCL5.
PubMed=8699119 [NCBI, ExPASy, EBI, Israel, Japan]
Combadiere C.,
Ahuja S.K.,
Tiffany H.L.,
Murphy P.M.;
"Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES.";
J. Leukoc. Biol. 60:147-152(1996).
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[4]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=9343222 [NCBI, ExPASy, EBI, Israel, Japan]
Kuhmann S.E.,
Platt E.J.,
Kozak S.L.,
Kabat D.;
"Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses.";
J. Virol. 71:8642-8656(1997).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA], AND POLYMORPHISM.
PubMed=9359654 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang L.,
Carruthers C.D.,
He T.,
Huang Y.,
Cao Y.,
Wang G.,
Hahn B.,
Ho D.D.;
"HIV type 1 subtypes, coreceptor usage, and CCR5 polymorphism.";
AIDS Res. Hum. Retroviruses 13:1357-1366(1997).
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[6]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1074/jbc.272.49.30662; PubMed=9388201 [NCBI, ExPASy, EBI, Israel, Japan]
Mummidi S.,
Ahuja S.S.,
McDaniel B.L.,
Ahuja S.K.;
"The human CC chemokine receptor 5 (CCR5) gene. Multiple transcripts with 5'-end heterogeneity, dual promoter usage, and evidence for polymorphisms within the regulatory regions and noncoding exons.";
J. Biol. Chem. 272:30662-30671(1997).
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[7]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ARG-178.
Magierowska M.,
Barre-Sinoussi F.,
Issafras H.,
Theodorou I.,
Debre P.;
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
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[8]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kopatz S.A.,
Aronstam R.S.,
Sharma S.V.;
"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).";
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
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[9]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04728; PubMed=16641997 [NCBI, ExPASy, EBI, Israel, Japan]
Muzny D.M.,
Scherer S.E.,
Kaul R.,
Wang J.,
Yu J.,
Sudbrak R.,
Buhay C.J.,
Chen R.,
Cree A.,
Ding Y.,
Dugan-Rocha S.,
Gill R.,
Gunaratne P.,
Harris R.A.,
Hawes A.C.,
Hernandez J.,
Hodgson A.V.,
Hume J.,
Jackson A., ![]()
Khan Z.M.,
Kovar-Smith C.,
Lewis L.R.,
Lozado R.J.,
Metzker M.L.,
Milosavljevic A.,
Miner G.R.,
Morgan M.B.,
Nazareth L.V.,
Scott G.,
Sodergren E.,
Song X.-Z.,
Steffen D.,
Wei S.,
Wheeler D.A.,
Wright M.W.,
Worley K.C.,
Yuan Y.,
Zhang Z.,
Adams C.Q.,
Ansari-Lari M.A.,
Ayele M.,
Brown M.J.,
Chen G.,
Chen Z.,
Clendenning J.,
Clerc-Blankenburg K.P.,
Chen R.,
Chen Z.,
Davis C.,
Delgado O.,
Dinh H.H.,
Dong W.,
Draper H.,
Ernst S.,
Fu G.,
Gonzalez-Garay M.L.,
Garcia D.K.,
Gillett W.,
Gu J.,
Hao B.,
Haugen E.,
Havlak P.,
He X.,
Hennig S.,
Hu S.,
Huang W.,
Jackson L.R.,
Jacob L.S.,
Kelly S.H.,
Kube M.,
Levy R.,
Li Z.,
Liu B.,
Liu J.,
Liu W.,
Lu J.,
Maheshwari M.,
Nguyen B.-V.,
Okwuonu G.O.,
Palmeiri A.,
Pasternak S.,
Perez L.M.,
Phelps K.A.,
Plopper F.J.,
Qiang B.,
Raymond C.,
Rodriguez R.,
Saenphimmachak C.,
Santibanez J.,
Shen H.,
Shen Y.,
Subramanian S.,
Tabor P.E.,
Verduzco D.,
Waldron L.,
Wang J.,
Wang J.,
Wang Q.,
Williams G.A.,
Wong G.K.-S.,
Yao Z.,
Zhang J.,
Zhang X.,
Zhao G.,
Zhou J.,
Zhou Y.,
Nelson D.,
Lehrach H.,
Reinhardt R.,
Naylor S.L.,
Yang H.,
Olson M.,
Weinstock G.,
Gibbs R.A.;
"The DNA sequence, annotation and analysis of human chromosome 3.";
Nature 440:1194-1198(2006).
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[10]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[11]
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FUNCION AS A HIV-1 CORECEPTOR.
DOI=10.1038/381661a0; PubMed=8649511 [NCBI, ExPASy, EBI, Israel, Japan]
Deng H.,
Liu R.,
Ellmeier W.,
Choe S.,
Unutmaz D.,
Burkhart M.,
di Marzio P.,
Marmon S.,
Sutton R.E.,
Hill C.M.,
Davis C.B.,
Peiper S.C.,
Schall T.J.,
Littman D.R.,
Landau N.R.;
"Identification of a major co-receptor for primary isolates of HIV-1.";
Nature 381:661-666(1996).
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[12]
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FUNCTION AS A HIV-1 CORECEPTOR.
DOI=10.1038/381667a0; PubMed=8649512 [NCBI, ExPASy, EBI, Israel, Japan]
Dragic T.,
Litwin V.,
Allaway G.P.,
Martin S.R.,
Huang Y.,
Nagashima K.A.,
Cayanan C.,
Maddon P.J.,
Koup R.A.,
Moore J.P.,
Paxton W.A.;
"HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.";
Nature 381:667-673(1996).
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[13]
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INTERACTION WITH HIV-1 SURFACE PROTEIN GP120.
DOI=10.1126/science.280.5371.1949; PubMed=9632396 [NCBI, ExPASy, EBI, Israel, Japan]
Rizzuto C.D.,
Wyatt R.,
Hernandez-Ramos N.,
Sun Y.,
Kwong P.D.,
Hendrickson W.A.,
Sodroski J.;
"A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding.";
Science 280:1949-1953(1998).
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[14]
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SULFATION AT TYR-3, GLYCOSYLATION, AND MUTAGENESIS OF TYR-3; TYR-10; TYR-14 AND TYR-15.
DOI=10.1016/S0092-8674(00)80577-2; PubMed=10089882 [NCBI, ExPASy, EBI, Israel, Japan]
Farzan M.,
Mirzabekov T.,
Kolchinsky P.,
Wyatt R.,
Cayabyab M.,
Gerard N.P.,
Gerard C.,
Sodroski J.,
Choe H.;
"Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry.";
Cell 96:667-676(1999).
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[15]
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PHOSPHORYLATION AT SER-336; SER-337; SER-342 AND SER-349, MUTAGENESIS OF SER-336; SER-337; SER-342 AND SER-349, AND INTERACTION WITH ADRBK1.
DOI=10.1074/jbc.274.13.8875; PubMed=10085131 [NCBI, ExPASy, EBI, Israel, Japan]
Oppermann M.,
Mack M.,
Proudfoot A.E.,
Olbrich H.;
"Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.";
J. Biol. Chem. 274:8875-8885(1999).
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[16]
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PALMITOYLATION AT CYS-321; CYS-323 AND CYS-324, SUBCELLULAR LOCATION, FUNCTION, AND MUTAGENESIS OF CYS-321; CYS-323 AND CYS-324.
DOI=10.1074/jbc.M100583200; PubMed=11323418 [NCBI, ExPASy, EBI, Israel, Japan]
Blanpain C.,
Wittamer V.,
Vanderwinden J.-M.,
Boom A.,
Renneboog B.,
Lee B.,
Le Poul E.,
El Asmar L.,
Govaerts C.,
Vassart G.,
Doms R.W.,
Parmentier M.;
"Palmitoylation of CCR5 is critical for receptor trafficking and efficient activation of intracellular signaling pathways.";
J. Biol. Chem. 276:23795-23804(2001).
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[17]
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SULFATION, GLYCOSYLATION AT SER-6, INTERACTION WITH CCL3; CCL4 AND CCL5, MUTAGENESIS OF TYR-3; SER-6; SER-7; TYR-10; TYR-14; TYR-15; THR-16 AND SER-17, AND CHARACTERIZATION OF VARIANT ASP-10.
DOI=10.1084/jem.194.11.1661; PubMed=11733580 [NCBI, ExPASy, EBI, Israel, Japan]
Bannert N.,
Craig S.,
Farzan M.,
Sogah D.,
Santo N.V.,
Choe H.,
Sodroski J.;
"Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines.";
J. Exp. Med. 194:1661-1673(2001).
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[18]
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INTERACTION WITH PRAF2.
DOI=10.1016/j.febslet.2005.02.037; PubMed=15757671 [NCBI, ExPASy, EBI, Israel, Japan]
Schweneker M.,
Bachmann A.S.,
Moelling K.;
"JM4 is a four-transmembrane protein binding to the CCR5 receptor.";
FEBS Lett. 579:1751-1758(2005).
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[19]
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INVOLVEMENT IN WEST NILE VIRUS INFECTION SUSCEPTIBILITY.
DOI=10.1084/jem.20051970; PubMed=16418398 [NCBI, ExPASy, EBI, Israel, Japan]
Glass W.G.,
McDermott D.H.,
Lim J.K.,
Lekhong S.,
Yu S.F.,
Frank W.A.,
Pape J.,
Cheshier R.C.,
Murphy P.M.;
"CCR5 deficiency increases risk of symptomatic West Nile virus infection.";
J. Exp. Med. 203:35-40(2006).
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[20]
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3D-STRUCTURE MODELING.
PubMed=12496074 [NCBI, ExPASy, EBI, Israel, Japan]
Paterlini M.G.;
"Structure modeling of the chemokine receptor CCR5: implications for ligand binding and selectivity.";
Biophys. J. 83:3012-3031(2002).
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[21]
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3D-STRUCTURE MODELING.
DOI=10.1007/s00894-003-0154-9; PubMed=14517611 [NCBI, ExPASy, EBI, Israel, Japan]
Liu S.,
Fan S.,
Sun Z.;
"Structural and functional characterization of the human CCR5 receptor in complex with HIV gp120 envelope glycoprotein and CD4 receptor by molecular modeling studies.";
J. Mol. Model. 9:329-336(2003).
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[22]
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VARIANTS GLN-55; LEU-215; GLN-223; VAL-335 AND PHE-339.
DOI=10.1038/ng0797-221; PubMed=9207783 [NCBI, ExPASy, EBI, Israel, Japan]
Ansari-Lari M.A.,
Liu X.-M.,
Metzker M.L.,
Rut A.R.,
Gibbs R.A.;
"The extent of genetic variation in the CCR5 gene.";
Nat. Genet. 16:221-222(1997).
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[23]
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VARIANTS LEU-12; SER-20; SER-29; PHE-42; GLN-55; SER-60; VAL-73; GLN-223; LYS-228 DEL; VAL-301; VAL-335 AND PHE-339, AND ASSOCIATION WITH SUSCEPTIBILITY TO HIV-1.
DOI=10.1086/301645; PubMed=9399903 [NCBI, ExPASy, EBI, Israel, Japan]
Carrington M.,
Kissner T.,
Gerrard B.,
Ivanov S.,
O'Brien S.J.,
Dean M.;
"Novel alleles of the chemokine-receptor gene CCR5.";
Am. J. Hum. Genet. 61:1261-1267(1997).
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[24]
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CHARACTERIZATION OF VARIANT SER-60.
DOI=10.1182/blood.V97.11.3651; PubMed=11369664 [NCBI, ExPASy, EBI, Israel, Japan]
Tamasauskas D.,
Powell V.,
Saksela K.,
Yazdanbakhsh K.;
"A homologous naturally occurring mutation in Duffy and CCR5 leading to reduced receptor expression.";
Blood 97:3651-3654(2001).
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