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UniProtKB/Swiss-Prot entry P51677


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CCR3_HUMAN
Primary accession number P51677
Secondary accession numbers Q15748 Q2YDB9 Q86WD2 Q9ULY8
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 87)
Name and origin of the protein
Protein name C-C chemokine receptor type 3
Synonyms C-C CKR-3
CC-CKR-3
CCR-3
CCR3
CKR3
Eosinophil eotaxin receptor
CD193 antigen
Gene name
Name: CCR3
Synonyms: CMKBR3
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Monocyte;
DOI=10.1074/jbc.270.28.16491; PubMed=7622448 [NCBI, ExPASy, EBI, Israel, Japan]
Combadiere C., Ahuja S.K., Murphy P.M.;
"Cloning and functional expression of a human eosinophil CC chemokine receptor.";
J. Biol. Chem. 270:16491-16494(1995).
[2]
ERRATUM.
Combadiere C., Ahuja S.K., Murphy P.M.;
J. Biol. Chem. 270:30235-30235(1995).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1084/jem.183.5.2349; PubMed=8642344 [NCBI, ExPASy, EBI, Israel, Japan]
Daugherty B.L., Siciliano S.J., Demartino J.A., Malkowitz L., Sirotina A., Springer M.S.;
"Cloning, expression, and characterization of the human eosinophil eotaxin receptor.";
J. Exp. Med. 183:2349-2354(1996).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1084/jem.183.6.2437; PubMed=8676064 [NCBI, ExPASy, EBI, Israel, Japan]
Ponath P.D., Qin S., Post T.W., Wang J., Wu L., Gerard N.P., Newman W., Gerard C., Mackay C.R.;
"Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils.";
J. Exp. Med. 183:2437-2448(1996).
[5]
NUCLEOTIDE SEQUENCE [MRNA].
Xiao L., Weiss S., Qari S., Rudolph D., Hodge T., Lal R.;
"Partial resistance to infection by syncytium-inducing primary HIV-1 in exposed uninfected individuals homozygous for CCR5 32bp deletion.";
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT SER-218.
DOI=10.1038/sj.gene.6363638; PubMed=11196669 [NCBI, ExPASy, EBI, Israel, Japan]
Kato H., Tsuchiya N., Izumi S., Miyamasu M., Nakajima T., Kawasaki H., Hirai K., Tokunaga K.;
"New variations of human CC-chemokine receptors CCR3 and CCR4.";
Genes Immun. 1:97-104(1999).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/geno.2002.6801; PubMed=12079287 [NCBI, ExPASy, EBI, Israel, Japan]
Vijh S., Dayhoff D.E., Wang C.E., Imam Z., Ehrenberg P.K., Michael N.L.;
"Transcription regulation of human chemokine receptor CCR3: evidence for a rare TATA-less promoter structure conserved between Drosophila and humans.";
Genomics 80:86-95(2002).
[8]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Kopatz S.A., Aronstam R.S., Sharma S.V.;
"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).";
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A.;
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
[10]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Blood;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[11]
INTERACTION WITH HIV-1 TAT.
DOI=10.1073/pnas.95.22.13153; PubMed=9789057 [NCBI, ExPASy, EBI, Israel, Japan]
Albini A., Ferrini S., Benelli R., Sforzini S., Giunciuglio D., Aluigi M.G., Proudfoot A.E.I., Alouani S., Wells T.N.C., Mariani G., Rabin R.L., Farber J.M., Noonan D.M.;
"HIV-1 Tat protein mimicry of chemokines.";
Proc. Natl. Acad. Sci. U.S.A. 95:13153-13158(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U28694; AAC50469.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U51241; AAB16831.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U49727; AAB09726.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF026535; AAB82589.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB023887; BAA86964.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF247361; AAL85154.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY221092; AAO65970.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EF064760; ABK41943.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC110297; AAI10298.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC130318; AAI30319.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC130320; AAI30321.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00019957; -.
PIR G02436; G02436.
RefSeq NP_001828.1; -.
NP_847899.1; -.
UniGene Hs.506190
3D structure databases
ModBase P51677.
Protein-protein interaction databases
DIP DIP:5846N; -.
Protein family/group databases
GPCRDB P51677; CCR3_HUMAN.
Enzyme and pathway databases
Reactome REACT_14797; Signaling by GPCR.
Organism-specific databases
GeneCards GC03P046227; -.
H-InvDB HIX0024274; -.
HGNC HGNC:1604; CCR3.
GenAtlas CCR3.
HPA CAB003795; -.
MIM 601268; gene. [NCBI / EBI]
PharmGKB PA26168; -.
Gene expression databases
ArrayExpress P51677; -.
Bgee P51677; -.
CleanEx HS_CCR3; -.
GermOnline ENSG00000183625; Homo sapiens.
Ontologies
GO
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0007155; Biological process: cell adhesion (traceable author statement from ProtInc).
GO:0006968; Biological process: cellular defense response (traceable author statement from ProtInc).
GO:0006935; Biological process: chemotaxis (traceable author statement from ProtInc).
GO:0007204; Biological process: elevation of cytosolic calcium ion concentration (traceable author statement from ProtInc).
GO:0007188; Biological process: G-protein signaling, coupled to cAMP nucleotide second messenger (traceable author statement from ProtInc).
GO:0006954; Biological process: inflammatory response (traceable author statement from ProtInc).
GO:0044419; Biological process: interspecies interaction between organisms (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000276; 7TM_GPCR_Rhodpsn.
IPR002238; CC_3_rcpt.
IPR000355; Chmkine_rcpt.
IPR017452; GPCR_Rhodpsn_supfam.
Graphical view of domain structure.
Pfam PF00001; 7tm_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00657; CCCHEMOKINER.
PR01108; CHEMOKINER3.
PR00237; GPCRRHODOPSN.
PROSITE PS00237; G_PROTEIN_RECEP_F1_1; 1.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE P51677; -.
Genome annotation databases
Ensembl ENSG00000183625; Homo sapiens. [Contig view]
GeneID 1232; -.
KEGG hsa:1232; -.
Phylogenomic databases
HOGENOM P51677; -.
HOVERGEN P51677; -.
OMA P51677; KTLLRCP.
Other
NextBio 5025; -.
SOURCE CCR3; Homo sapiens.
GPCRDB-Snakes P51677.
ProtoNet P51677.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Disulfide bond; G-protein coupled receptor; Host-virus interaction; Membrane; Polymorphism; Receptor; Transducer; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   355  355     C-C chemokine receptor type 3. PRO_0000069239
TOPO_DOM   1    34  34     Extracellular (Potential). 
TRANSMEM   35    62  28     1 (Potential). 
TOPO_DOM   63    72  10     Cytoplasmic (Potential). 
TRANSMEM   73    93  21     2 (Potential). 
TOPO_DOM   94   107  14     Extracellular (Potential). 
TRANSMEM   108   129  22     3 (Potential). 
TOPO_DOM   130   146  17     Cytoplasmic (Potential). 
TRANSMEM   147   171  25     4 (Potential). 
TOPO_DOM   172   203  32     Extracellular (Potential). 
TRANSMEM   204   223  20     5 (Potential). 
TOPO_DOM   224   239  16     Cytoplasmic (Potential). 
TRANSMEM   240   264  25     6 (Potential). 
TOPO_DOM   265   281  17     Extracellular (Potential). 
TRANSMEM   282   305  24     7 (Potential). 
TOPO_DOM   306   355  50     Cytoplasmic (Potential). 
DISULFID   106   183        By similarity. 
VARIANT   21    21  1     G -> D (in dbSNP:rs4987125 [NCBI]). VAR_020067 
VARIANT   39    39  1     P -> L (in dbSNP:rs5742906 [NCBI]). VAR_049382 
VARIANT   218   218  1     C -> S (polymorphism found in about 7% of the population; may show reduced activity). VAR_010668 
CONFLICT   276   276        S -> T (in Ref. 4 and 5). 
Sequence information
Length: 355 AA [This is the length of the unprocessed precursor] Molecular weight: 41044 Da [This is the MW of the unprocessed precursor] CRC64: E95DCD7A6C643874 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTTSLDTVET FGTTSYYDDV GLLCEKADTR ALMAQFVPPL YSLVFTVGLL GNVVVVMILI 

        70         80         90        100        110        120 
KYRRLRIMTN IYLLNLAISD LLFLVTLPFW IHYVRGHNWV FGHGMCKLLS GFYHTGLYSE 

       130        140        150        160        170        180 
IFFIILLTID RYLAIVHAVF ALRARTVTFG VITSIVTWGL AVLAALPEFI FYETEELFEE 

       190        200        210        220        230        240 
TLCSALYPED TVYSWRHFHT LRMTIFCLVL PLLVMAICYT GIIKTLLRCP SKKKYKAIRL 

       250        260        270        280        290        300 
IFVIMAVFFI FWTPYNVAIL LSSYQSILFG NDCERSKHLD LVMLVTEVIA YSHCCMNPVI 

       310        320        330        340        350 
YAFVGERFRK YLRHFFHRHL LMHLGRYIPF LPSEKLERTS SVSPSTAEPE LSIVF 

P51677 in FASTA format

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