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UniProtKB/Swiss-Prot entry P51656

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHB1_MOUSE
Primary accession number P51656
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 59)
Name and origin of the protein
Protein name Estradiol 17-beta-dehydrogenase 1
Synonyms EC 1.1.1.62
17-beta-hydroxysteroid dehydrogenase type 1
17-beta-HSD 1
Gene name
Name: Hsd17b1
Synonyms: Edh17b1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Ovary;
PubMed=8612620 [NCBI, ExPASy, EBI, Israel, Japan]
Nokelainen P., Puranen T., Peltoketo H., Orava M., Vihko P., Vihko R.;
"Molecular cloning of mouse 17 beta-hydroxysteroid dehydrogenase type 1 and characterization of enzyme activity.";
Eur. J. Biochem. 236:482-490(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X89627; CAA61770.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S62652; S62652.
RefSeq NP_034605.1; -.
UniGene Mm.188939
3D structure databases
HSSP P14061; 1FDW. [HSSP ENTRY / PDB]
SMR P51656; 4-284.
ModBase P51656.
Organism-specific databases
MGI MGI:105077; Hsd17b1.
Gene expression databases
ArrayExpress P51656; -.
CleanEx MM_HSD17B1; -.
GermOnline ENSMUSG00000019301; Mus musculus.
Family and domain databases
InterPro IPR011348; 17beta_DHase.
IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR19410:SF47; 17beta_DH; 1.
PTHR19410; ADH_short_C2; 1.
Pfam PF00106; adh_short; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000095; 17beta-HSD; 1.
PRINTS PR00081; GDHRDH.
PR00080; SDRFAMILY.
PROSITE PS00061; ADH_SHORT; 1.
BLOCKS P51656.
Genome annotation databases
Ensembl ENSMUSG00000019301; Mus musculus. [Contig view]
GeneID 15485; -.
KEGG mmu:15485; -.
Phylogenomic databases
HOGENOM P51656; -.
HOVERGEN P51656; -.
Other
SOURCE Hsd17b1; Mus musculus.
ProtoNet P51656.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Lipid synthesis; NAD; Oxidoreductase; Steroid biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   344  344     Estradiol 17-beta-dehydrogenase 1. PRO_0000054568
NP_BIND   3    32  30     NAD (By similarity). 
ACT_SITE   156   156        Proton acceptor (By similarity). 
BINDING   143   143        Substrate (By similarity). 
Sequence information
Length: 344 AA [This is the length of the unprocessed precursor] Molecular weight: 36785 Da [This is the MW of the unprocessed precursor] CRC64: 0335C473F453C14A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDPTVVLITG CSSGIGMHLA VRLASDRSQS FKVYATLRDL KAQGPLLEAA RTQGCPPGSL 

        70         80         90        100        110        120 
EILELDVRDS KSVAAAQACV TEGRVDVLVC NAGRGLFGPL EAHELNAVGA VLDVNVLGTI 

       130        140        150        160        170        180 
RMLQAFLPDM KRRHSGRVLV TASVGGLMGL PFHEVYCASK FALEGLCESL AILLPLFGVH 

       190        200        210        220        230        240 
VSLIECGAVH TAFYEKLVGG PGGALERADA QTRHLFAHYL RGYEQALSEA QDPEEVTELF 

       250        260        270        280        290        300 
LTAMRAPQPA LRYFSTNRFL PLARMRTEDP SGSSYVAAMH QEAFSNLQTQ ENAKAGAQVP 

       310        320        330        340 
GVSDTASSAL ICLPECAIPR VASELGWSAS DKPGQDNSCY QQKI
P51656 in FASTA format

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