NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Nine Mile;
DOI=10.1016/0378-1119(94)00888-Y; PubMed=7698664 [NCBI, ExPASy, EBI, Israel, Japan]
Heinzen R.A., Mo Y.-Y., Robertson S.J., Mallavia L.P.;
"Characterization of the succinate dehydrogenase-encoding gene cluster (sdh) from the rickettsia Coxiella burnetii.";
Gene 155:27-34(1995).

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Nine Mile phase I / RSA 493;
DOI=10.1073/pnas.0931379100; PubMed=12704232 [NCBI, ExPASy, EBI, Israel, Japan]
Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A., Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F.;
"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii.";
Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003).

Comments

CATALYTIC ACTIVITY: Succinate + acceptor = fumarate + reduced acceptor.
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle .
SUBUNIT: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, cytochrome b-556 and a hydrophobic protein.
SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).
SIMILARITY: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L33409; AAA74133.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AE016828; AAO90900.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

I40849; I40849.

RefSeq

NP_820386.1; -.

3D structure databases

HSSP

P10444; 1NEK. [HSSP ENTRY / PDB]

ModBase

P51054.

Enzyme and pathway databases

BioCyc

CBUR227377:CBU_1401-MON; -.

Family and domain databases

InterPro

IPR003953; FAD_bind2_N.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR003952; FRD_SDH_FAD_BS.
IPR004112; Fum_Rdtase/Succ_DHase_flav_C.
IPR011281; Succ_DHase_flav_su_fwd.
IPR014006; Succ_Dhase_frdA_Gneg.
Graphical view of domain structure.

Pfam

PF00890; FAD_binding_2; 1.
PF02910; Succ_DH_flav_C; 1.
Pfam graphical view of domain structure.

PRINTS

PR00368; FADPNR.

TIGRFAMs

TIGR01816; sdhA_forward; 1.
TIGR01812; sdhA_frdA_Gneg; 1.

PROSITE

PS00504; FRD_SDH_FAD_BINDING; 1.

BLOCKS

P51054.

Genome annotation databases

GeneID

1209307; -.

GenomeReviews

AE016828_GR; CBU_1401.

KEGG

cbu:CBU_1401; -.

TIGR

CBU_1401; -.

Phylogenomic databases

HOGENOM

P51054; -.

Other

ProtoNet

P51054.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell inner membrane; Cell membrane; Complete proteome; Electron transport; FAD; Flavoprotein; Membrane; Oxidoreductase; Transport; Tricarboxylic acid cycle.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 587`	`587`	`Succinate dehydrogenase flavoprotein subunit.`	`PRO_0000158651`
`NP_BIND`	`39 54`	`16`	`FAD (By similarity).`
`ACT_SITE`	`288 288`		`Proton acceptor (By similarity).`
`BINDING`	`244 244`		`Substrate (By similarity).`
`BINDING`	`256 256`		`Substrate (By similarity).`
`BINDING`	`355 355`		`Substrate (By similarity).`
`BINDING`	`400 400`		`Substrate (By similarity).`
`MOD_RES`	`47 47`		`Tele-8alpha-FAD histidine (By similarity).`

Sequence information

Length: 587 AA [This is the length of the unprocessed precursor]

Molecular weight: 65438 Da [This is the MW of the unprocessed precursor]

CRC64: 37B264ECC98D3DB6 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSSIRVKQYD ALIVGAGGAG LRAALEMAQS RQYKVAVVSK VFPTRSHTVS AQGGIAAALG 

        70         80         90        100        110        120 
NVVPDKPIWH MFDTVKGSDY LGDQDAIQYM CEQAPPSVYE LEHYGLPFSR LDDGRIYQRA 

       130        140        150        160        170        180 
FGGHTRDFGK EMARRTCACA DRTGHAMLHT LYQKNVEAGT HFYYEWYGID LVRGAQGGIA 

       190        200        210        220        230        240 
GMIAMNMETS ELVFFKSRAT IFATGGAGRI YETTSNAYTN TGDGIGMVLR AGLPVQDMEF 

       250        260        270        280        290        300 
WQFHPTGIYG VGCLITEGAR GEGGYLINKD GERFMERYSP HLKDLDCRDV VARSILQEVM 

       310        320        330        340        350        360 
AGGGVGPKKD HVLLKLDHLG EKVLRERLPG IIELSEKFAN VDITKEPIPI LPTCHYMMGG 

       370        380        390        400        410        420 
IPTNIHGQAL TVDENGKDQI IEGLFAAGEC ACVSVHGANR LGTNSLLDLV VFGRAIGLHL 

       430        440        450        460        470        480 
EEALKTELKH RSENPDDIDA AIARLKRWEK PNNVENPALL RQEMRKAMSE DFGVFREEQK 

       490        500        510        520        530        540 
MKQGLERLQK LNERLQRAKL TDTSRTFNNA RIEALELDNL MEVSYATAVS AQQRTESRGA 

       550        560        570        580 
HSRYDYKERD DANWLKHTVY FRDGHIAYRP VNMKPKGMDP FPPKSRD

P51054 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools