[1]	NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 32-67 AND 182-203, AND VARIANT ALA-539. TISSUE=Placenta; PubMed=7777537 [NCBI, ExPASy, EBI, Israel, Japan] Parsons S.F., Mallinson G., Holmes C.H., Houlihan J.M., Simpson K.L., Mawby W.J., Spurr N.K., Warne D., Barclay A.N., Anstee D.J.; "The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver."; Proc. Natl. Acad. Sci. U.S.A. 92:5496-5500(1995).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS HIS-77; ILE-196; LYS-204; HIS-282; ILE-381; GLN-451 AND LEU-581. SeattleSNPs program for genomic applications; Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[4]	NUCLEOTIDE SEQUENCE [MRNA] OF 1-588, AND VARIANT ALA-539. PubMed=7954395 [NCBI, ExPASy, EBI, Israel, Japan] Campbell I.G., Foulkes W.D., Senger G., Trowsdale J., Garin-Chesa P., Rettig W.J.; "Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily."; Cancer Res. 54:5761-5765(1994).
[5]	GLYCOSYLATION AT ASN-439. DOI=10.1038/nbt827; PubMed=12754519 [NCBI, ExPASy, EBI, Israel, Japan] Zhang H., Li X.-J., Martin D.B., Aebersold R.; "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."; Nat. Biotechnol. 21:660-666(2003).
[6]	GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-439, AND MASS SPECTROMETRY. TISSUE=Plasma; DOI=10.1021/pr0502065; PubMed=16335952 [NCBI, ExPASy, EBI, Israel, Japan] Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.; "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."; J. Proteome Res. 4:2070-2080(2005).

Comments

FUNCTION: Probable receptor. May mediate intraellular signaling.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.
DEVELOPMENTAL STAGE: Is under developmental control in liver and may also be regulated during differentiation in other tissues. Up-regulated following malignant transformation in some cell types.
POLYMORPHISM: LU is responsible for the Lutheran blood group system.
SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
SIMILARITY: Contains 2 Ig-like V-type (immunoglobulin-like) domains.
WEB RESOURCE: Name=BGMUT; Note=Blood group antigen gene mutation database"; URL="http://www.ncbi.nlm.nih.gov/projects/mhc/xslcgi.fcgi?cmd=bgmut/systems_info&system=lutheran";.
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/lu/";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X83425; CAA58449.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY845133; AAV88096.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC050450; AAH50450.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X80026; CAA56327.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

I37202; I37202.
I38000; I38000.

RefSeq

NP_001013275.1; -.
NP_005572.2; -.

UniGene

Hs.654540

3D structure databases

PDB

2PET; X-ray; 1.70 A; A=32-262.	[ExPASy / RCSB / EBI]
2PF6; X-ray; 2.20 A; A/B=32-262.	[ExPASy / RCSB / EBI]

Detailed list of linked structures.

PDBsum

2PET; -.
2PF6; -.

ModBase

P50895.

Organism-specific databases

HIX0027520; -.

HGNC:6722; BCAM.

111200; gene+phenotype. [NCBI / EBI]

PharmGKB

PA30484; -.

GeneCards

P50895.

Gene expression databases

ArrayExpress

P50895; -.

CleanEx

HS_BCAM; -.

GermOnline

ENSG00000187244; Homo sapiens.

Ontologies

GO:0009986;	Cellular component: cell surface (inferred from direct assay from UniProtKB).
GO:0005887;	Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0004888;	Molecular function: transmembrane receptor activity (traceable author statement from ProtInc).
GO:0007155;	Biological process: cell adhesion (traceable author statement from ProtInc).
GO:0007165;	Biological process: signal transduction (traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR013162; CD80_C2-set.
IPR013151; Ig.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013106; Ig_V-set.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.40.10; Ig-like_fold; 4.

Pfam

PF08205; C2-set_2; 1.
PF00047; ig; 3.
PF07686; V-set; 1.
Pfam graphical view of domain structure.

SMART

SM00409; IG; 2.
SM00408; IGc2; 2.
SMART graphical view of domain structure.

PROSITE

PS50835; IG_LIKE; 5.
PROSITE graphical view of domain structure (profiles).

BLOCKS

P50895.

Genome annotation databases

Ensembl

ENSG00000187244; Homo sapiens. [Contig view]

GeneID

4059; -.

KEGG

hsa:4059; -.

Phylogenomic databases

HOGENOM

P50895; -.

HOVERGEN

P50895; -.

Other

BCAM; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Blood group antigen; Direct protein sequencing; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Receptor; Repeat; Signal; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 31`	`31`
`CHAIN`	`32 628`	`597`	`Lutheran blood group glycoprotein.`	`PRO_0000014850`
`TOPO_DOM`	`32 547`	`516`	`Extracellular (Potential).`
`TRANSMEM`	`548 568`	`21`	`Potential.`
`TOPO_DOM`	`569 628`	`60`	`Cytoplasmic (Potential).`
`DOMAIN`	`32 142`	`111`	`Ig-like V-type 1.`
`DOMAIN`	`147 257`	`111`	`Ig-like V-type 2.`
`DOMAIN`	`274 355`	`82`	`Ig-like C2-type 1.`
`DOMAIN`	`363 441`	`79`	`Ig-like C2-type 2.`
`DOMAIN`	`448 541`	`94`	`Ig-like C2-type 3.`
`CARBOHYD`	`321 321`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`377 377`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`383 383`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`419 419`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`439 439`		`N-linked (GlcNAc...).`
`DISULFID`	`53 125`		`Probable.`
`DISULFID`	`172 237`		`Probable.`
`DISULFID`	`291 337`		`Probable.`
`DISULFID`	`384 424`		`Probable.`
`DISULFID`	`473 522`		`Probable.`
`VARIANT`	`77 77`	`1`	`R -> H.`	`VAR_021348 [3D]`
`VARIANT`	`196 196`	`1`	`V -> I.`	`VAR_021349 [3D]`
`VARIANT`	`204 204`	`1`	`M -> K.`	`VAR_021350 [3D]`
`VARIANT`	`282 282`	`1`	`R -> H.`	`VAR_021351`
`VARIANT`	`381 381`	`1`	`V -> I.`	`VAR_021352`
`VARIANT`	`451 451`	`1`	`K -> Q.`	`VAR_021353`
`VARIANT`	`539 539`	`1`	`T -> A.`	`VAR_021354`
`VARIANT`	`581 581`	`1`	`Q -> L.`	`VAR_021355`
`CONFLICT`	`225 226`		`RL -> PC (in Ref. 4; CAA56327).`
`CONFLICT`	`355 356`		`EL -> DV (in Ref. 4; CAA56327).`

Sequence information

Length: 628 AA [This is the length of the unprocessed precursor]

Molecular weight: 67405 Da [This is the MW of the unprocessed precursor]

CRC64: C88F4F5C640C3F5B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEPPDAPAQA RGAPRLLLLA VLLAAHPDAQ AEVRLSVPPL VEVMRGKSVI LDCTPTGTHD 

        70         80         90        100        110        120 
HYMLEWFLTD RSGARPRLAS AEMQGSELQV TMHDTRGRSP PYQLDSQGRL VLAEAQVGDE 

       130        140        150        160        170        180 
RDYVCVVRAG AAGTAEATAR LNVFAKPEAT EVSPNKGTLS VMEDSAQEIA TCNSRNGNPA 

       190        200        210        220        230        240 
PKITWYRNGQ RLEVPVEMNP EGYMTSRTVR EASGLLSLTS TLYLRLRKDD RDASFHCAAH 

       250        260        270        280        290        300 
YSLPEGRHGR LDSPTFHLTL HYPTEHVQFW VGSPSTPAGW VREGDTVQLL CRGDGSPSPE 

       310        320        330        340        350        360 
YTLFRLQDEQ EEVLNVNLEG NLTLEGVTRG QSGTYGCRVE DYDAADDVQL SKTLELRVAY 

       370        380        390        400        410        420 
LDPLELSEGK VLSLPLNSSA VVNCSVHGLP TPALRWTKDS TPLGDGPMLS LSSITFDSNG 

       430        440        450        460        470        480 
TYVCEASLPT VPVLSRTQNF TLLVQGSPEL KTAEIEPKAD GSWREGDEVT LICSARGHPD 

       490        500        510        520        530        540 
PKLSWSQLGG SPAEPIPGRQ GWVSSSLTLK VTSALSRDGI SCEASNPHGN KRHVFHFGTV 

       550        560        570        580        590        600 
SPQTSQAGVA VMAVAVSVGL LLLVVAVFYC VRRKGGPCCR QRREKGAPPP GEPGLSHSGS 

       610        620 
EQPEQTGLLM GGASGGARGG SGGFGDEC

P50895 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools