[1]
|
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
DOI=10.1083/jcb.127.2.467; PubMed=7929589 [NCBI, ExPASy, EBI, Israel, Japan]
Tassan J.-P.,
Schultz S.J.,
Bartek J.,
Nigg E.A.;
"Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase).";
J. Cell Biol. 127:467-478(1994).
|
[2]
|
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Mammary gland;
PubMed=8208544 [NCBI, ExPASy, EBI, Israel, Japan]
Levedakou E.N.,
He M.,
Baptist E.W.,
Craven R.J.,
Cance W.G.,
Welcsh P.L.,
Simmons A.,
Naylor S.L.,
Leach R.J.,
Lewis T.B.,
Bowcock A.,
Liu E.T.;
"Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern.";
Oncogene 9:1977-1988(1994).
|
[3]
|
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7936635 [NCBI, ExPASy, EBI, Israel, Japan]
Darbon J.-M.,
Devault A.,
Taviaux S.,
Fesquet D.,
Martinez A.-M.,
Galas S.,
Cavadore J.-C.,
Doree M.,
Blanchard J.-M.;
"Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase.";
Oncogene 9:3127-3138(1994).
|
[4]
|
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Fibroblast;
PubMed=8208556 [NCBI, ExPASy, EBI, Israel, Japan]
Wu L.,
Yee A.,
Liu L.,
Carbonaro-Hall D.,
Venkatesan N.,
Tolo T.,
Hall F.L.;
"Molecular cloning of the human CAK1 gene encoding a cyclin-dependent kinase-activating kinase.";
Oncogene 9:2089-2096(1994).
|
[5]
|
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lung, and Thymus;
Kobelt D.,
Karn T.,
Hock B.,
Holtrich U.,
Braeuninger A.,
Wolf G.,
Strebhardt K.,
Ruebsamen-Waigmann H.;
"Human and Xenopus MO15 mRNA are highly conserved but show different patterns of expression in adult tissues.";
Oncol. Rep. 1:1269-1275(1994).
|
[6]
|
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-163 AND MET-285.
NIEHS SNPs program;
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
|
[7]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Cervix, and Urinary bladder;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
|
[8]
|
MUTAGENESIS OF THR-170.
DOI=10.1016/0092-8674(94)90535-5; PubMed=8069918 [NCBI, ExPASy, EBI, Israel, Japan]
Fisher R.P.,
Morgan D.O.;
"A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase.";
Cell 78:713-724(1994).
|
[9]
|
FUNCTION.
DOI=10.1016/S1097-2765(00)80177-X; PubMed=10024882 [NCBI, ExPASy, EBI, Israel, Japan]
Tirode F.,
Busso D.,
Coin F.,
Egly J.-M.;
"Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.";
Mol. Cell 3:87-95(1999).
|
[10]
|
PHOSPHORYLATION AT SER-164 AND THR-170, AND MUTAGENESIS OF SER-164 AND THR-170.
PubMed=9832506 [NCBI, ExPASy, EBI, Israel, Japan]
Akoulitchev S.,
Reinberg D.;
"The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7.";
Genes Dev. 12:3541-3550(1998).
|
[11]
|
INTERACTION WITH PUF60.
DOI=10.1016/S1097-2765(00)80428-1; PubMed=10882074 [NCBI, ExPASy, EBI, Israel, Japan]
Liu J.,
He L.,
Collins I.,
Ge H.,
Libutti D.,
Li J.,
Egly J.-M.,
Levens D.;
"The FBP interacting repressor targets TFIIH to inhibit activated transcription.";
Mol. Cell 5:331-341(2000).
|
[12]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164 AND THR-170, AND MASS SPECTROMETRY.
DOI=10.1074/mcp.T600062-MCP200; PubMed=17192257 [NCBI, ExPASy, EBI, Israel, Japan]
Wissing J.,
Jaensch L.,
Nimtz M.,
Dieterich G.,
Hornberger R.,
Keri G.,
Wehland J.,
Daub H.;
"Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.";
Mol. Cell. Proteomics 6:537-547(2007).
|
[13]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-170, AND MASS SPECTROMETRY.
DOI=10.1021/pr0705441; PubMed=18220336 [NCBI, ExPASy, EBI, Israel, Japan]
Cantin G.T.,
Yi W.,
Lu B.,
Park S.K.,
Xu T.,
Lee J.-D.,
Yates J.R. III;
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.";
J. Proteome Res. 7:1346-1351(2008).
|
[14]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7; SER-164; THR-170; THR-287 AND SER-321, AND MASS SPECTROMETRY.
DOI=10.1016/j.molcel.2008.07.007; PubMed=18691976 [NCBI, ExPASy, EBI, Israel, Japan]
Daub H.,
Olsen J.V.,
Bairlein M.,
Gnad F.,
Oppermann F.S.,
Korner R.,
Greff Z.,
Keri G.,
Stemmann O.,
Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
|
[15]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164 AND THR-170, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N.,
Zhou C.,
Villen J.,
Beausoleil S.A.,
Bakalarski C.E.,
Elledge S.J.,
Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
|
[16]
|
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J.,
Superti-Furga G.,
Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
|
[17]
|
X-RAY CRYSTALLOGRAPHY (3.02 ANGSTROMS) IN COMPLEX WITH ATP, ACTIVE SITE, AND PHOSPHORYLATION AT THR-170.
DOI=10.1016/j.str.2004.08.013; PubMed=15530371 [NCBI, ExPASy, EBI, Israel, Japan]
Lolli G.,
Lowe E.D.,
Brown N.R.,
Johnson L.N.;
"The crystal structure of human CDK7 and its protein recognition properties.";
Structure 12:2067-2079(2004).
|
[18]
|
VARIANT [LARGE SCALE ANALYSIS] MET-285.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C.,
Stephens P.,
Smith R.,
Dalgliesh G.L.,
Hunter C.,
Bignell G.,
Davies H.,
Teague J.,
Butler A.,
Stevens C.,
Edkins S.,
O'Meara S.,
Vastrik I.,
Schmidt E.E.,
Avis T.,
Barthorpe S.,
Bhamra G.,
Buck G.,
Choudhury B., ![]()
Clements J.,
Cole J.,
Dicks E.,
Forbes S.,
Gray K.,
Halliday K.,
Harrison R.,
Hills K.,
Hinton J.,
Jenkinson A.,
Jones D.,
Menzies A.,
Mironenko T.,
Perry J.,
Raine K.,
Richardson D.,
Shepherd R.,
Small A.,
Tofts C.,
Varian J.,
Webb T.,
West S.,
Widaa S.,
Yates A.,
Cahill D.P.,
Louis D.N.,
Goldstraw P.,
Nicholson A.G.,
Brasseur F.,
Looijenga L.,
Weber B.L.,
Chiew Y.-E.,
DeFazio A.,
Greaves M.F.,
Green A.R.,
Campbell P.,
Birney E.,
Easton D.F.,
Chenevix-Trench G.,
Tan M.-H.,
Khoo S.K.,
Teh B.T.,
Yuen S.T.,
Leung S.Y.,
Wooster R.,
Futreal P.A.,
Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
|
|
ExPASy Home page
SIB Switzerland
