[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1038/365644a0; PubMed=8413626 [NCBI, ExPASy, EBI, Israel, Japan] Estevez M., Attisano L., Wrana J.L., Albert P.S., Massague J., Riddle D.L.; "The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development."; Nature 365:644-649(1993).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=Bristol N2; DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan] The C. elegans sequencing consortium; "Genome sequence of the nematode C. elegans: a platform for investigating biology."; Science 282:2012-2018(1998).
[3]	FUNCTION, SUBUNIT, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE. PubMed=10887089 [NCBI, ExPASy, EBI, Israel, Japan] Gunther C.V., Georgi L.L., Riddle D.L.; "A Caenorhabditis elegans type I TGF beta receptor can function in the absence of type II kinase to promote larval development."; Development 127:3337-3347(2000).
[4]	GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-60 AND ASN-134, AND MASS SPECTROMETRY. DOI=10.1074/mcp.M600392-MCP200; PubMed=17761667 [NCBI, ExPASy, EBI, Israel, Japan] Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.; "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."; Mol. Cell. Proteomics 6:2100-2109(2007).

Comments

FUNCTION: Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning.
CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
SUBUNIT: May interact with daf-1 to regulate dauer larva development.
INTERACTION:
P46561:atp-2; NbExp=1; IntAct=EBI-296172, EBI-316294;
O45799:scrm-1; NbExp=1; IntAct=EBI-296172, EBI-312683;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Pharynx, intestine, hypodermis and body wall muscles in L1 through to adult stages. Also expressed in head neurons, ventral cord and tail neurons. Subset of head neurons show coexpression with daf-1 when dauer/nondauer decision is made.
SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L23110; AAA03544.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF047651; AAC02726.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

D88462; D88462.
S38279; S38279.

RefSeq

NP_498211.1; -.

UniGene

Cel.6349

3D structure databases

HSSP

P36897; 1IAS. [HSSP ENTRY / PDB]

ModBase

P50488.

Protein-protein interaction databases

IntAct

P50488; -.

Organism-specific databases

WormBase

WBGene00000900; daf-4.

WormPep

C05D2.1a; CE16827. [WormPep / WorfDB]

Gene expression databases

ArrayExpress

P50488; -.

Ontologies

GO:0005515;	Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0040024;	Biological process: dauer larval development (inferred from mutant phenotype from WormBase).
GO:0030514;	Biological process: negative regulation of BMP signaling pathway (inferred from mutant phenotype from WormBase).
GO:0018991;	Biological process: oviposition (inferred from mutant phenotype from WormBase).
GO:0030513;	Biological process: positive regulation of BMP signaling pathway (inferred from mutant phenotype from WormBase).
GO:0040010;	Biological process: positive regulation of growth rate (inferred from mutant phenotype from WormBase).
GO:0040018;	Biological process: positive regulation of multicellular organism growth (inferred from mutant phenotype from WormBase).
QuickGo view.

Family and domain databases

InterPro

IPR000333; Activin_II_recpt.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
Graphical view of domain structure.

Pfam

PF00069; Pkinase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00653; ACTIVIN2R.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

P50488.

Genome annotation databases

Ensembl

C05D2.1; Caenorhabditis elegans. [Contig view]

GeneID

175781; -.

Other

ProtoNet

P50488.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Complete proteome; Developmental protein; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 31`	`31`	`Potential.`
`CHAIN`	`32 744`	`713`	`Cell surface receptor daf-4.`	`PRO_0000024431`
`TOPO_DOM`	`48 253`	`206`	`Extracellular (Potential).`
`TRANSMEM`	`254 274`	`21`	`Potential.`
`TOPO_DOM`	`275 744`	`470`	`Cytoplasmic (Potential).`
`DOMAIN`	`306 603`	`298`	`Protein kinase.`
`NP_BIND`	`312 320`	`9`	`ATP (By similarity).`
`ACT_SITE`	`440 440`		`Proton acceptor (By similarity).`
`BINDING`	`338 338`		`ATP (By similarity).`
`CARBOHYD`	`60 60`		`N-linked (GlcNAc...).`
`CARBOHYD`	`134 134`		`N-linked (GlcNAc...).`
`CARBOHYD`	`165 165`		`N-linked (GlcNAc...) (Potential).`
`CONFLICT`	`374 374`		`A -> P (in Ref. 1; AAA03544).`
`CONFLICT`	`545 545`		`L -> R (in Ref. 1; AAA03544).`

Sequence information

Length: 744 AA [This is the length of the unprocessed precursor]

Molecular weight: 84410 Da [This is the MW of the unprocessed precursor]

CRC64: 33C087871FD81AF0 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNQKGTVRLK ALVLICLPLF LIATPVPVAV TEDDRQDRIE SEAAEKEWAN TLVSKVAQSN 

        70         80         90        100        110        120 
GTGTIKVSAP AKPTLRRMDN EEDEVISIEC VYYDEMECEK SGDCEITKKT CYSEAHLKAV 

       130        140        150        160        170        180 
GCLAVFGLPT QEINSTEPYL KVDKPQYKSL GCMPYQHADS MNCENESSCR QGRSFRGGIG 

       190        200        210        220        230        240 
MCCCSTNNCN MPDLIEMVNP SLKKDSDNSA LLWASTPSNM DLESLDKFPF YWIIIIALSV 

       250        260        270        280        290        300 
ILCIALLILA YVGWKFQQNK KEEIKKQQKI KFDMEKTDAL EAGNVPLVEP EEEMIEMVET 

       310        320        330        340        350        360 
PKELPITDFQ LISKGRFGKV FKAQYTPDSG EKRLVAVKKL NEFQKASFLA EKRIFDELNE 

       370        380        390        400        410        420 
YPKWYKSIVE FVCAEKIGDE YWIVTEFHER LSLYELLKNN VISITSANRI IMSMIDGLQF 

       430        440        450        460        470        480 
LHDDRPYFFG HPKKPIIHRD IKSKNILVKS DMTTCIADFG LARIYSYDIE QSDLLGQVGT 

       490        500        510        520        530        540 
KRYMSPEMLE GATEFTPTAF KAMDVYSMGL VMWEVISRTK LHQTDEPPNY QMPFQVIGFD 

       550        560        570        580        590        600 
PTIGLMRNYV VSKKERPQWR DEIIKHEYMS LLKKVTEEMW DPEACARITA GCAFARVWNH 

       610        620        630        640        650        660 
IMSSPDSSEG YHSGSSMKNR GVDDVEQSEK PEGIEEMQHY HASSPSKRQH PSPNPFFDSC 

       670        680        690        700        710        720 
PPPPPIPVIL ENGGILQPDN AEPEPEELPD LPIVEKIYDI ATNMLFSREE LDLMNAQRQV 

       730        740 
EYEAGADTRA STPTPSGTFG TFTT

P50488 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools