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UniProtKB/Swiss-Prot entry P50215

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDH_SPHYA
Primary accession number P50215
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 45)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP]
Synonyms IDH
EC 1.1.1.42
Oxalosuccinate decarboxylase
NADP(+)-specific ICDH
IDP
Gene name
Name: icd
Synonyms: idhA
From
Sphingomonas yanoikuyae [TaxID: 13690] 
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales; Sphingomonadaceae; Sphingobium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=B1;
DOI=10.1016/0378-1119(95)00732-6; PubMed=8626059 [NCBI, ExPASy, EBI, Israel, Japan]
Wang Y., Lau P.C.K.;
"Sequence and expression of an isocitrate dehydrogenase-encoding gene from a polycyclic aromatic hydrocarbon oxidizer, Sphingomonas yanoikuyae B1.";
Gene 168:15-21(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U37523; AAC43640.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JC4600; JC4600.
3D structure databases
HSSP P33198; 1LWD. [HSSP ENTRY / PDB]
ModBase P50215.
Family and domain databases
InterPro IPR004790; IsoCit_DHase_NADP-dep_euk.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11822; IDH_NADP_euk; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000108; IDH_NADP; 1.
TIGRFAMs TIGR00127; nadp_idh_euk; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS P50215.
Other
ProtoNet P50215.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Phosphoprotein; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   406  406     Isocitrate dehydrogenase [NADP]. PRO_0000083567
NP_BIND   75    77  3     NADP (By similarity). 
NP_BIND   308   313  6     NADP (By similarity). 
REGION   94   100  7     Substrate binding (By similarity). 
METAL   250   250        Magnesium or manganese (By similarity). 
METAL   273   273        Magnesium or manganese (By similarity). 
BINDING   77    77        Substrate (By similarity). 
BINDING   82    82        NADP (By similarity). 
BINDING   109   109        Substrate (By similarity). 
BINDING   132   132        Substrate (By similarity). 
BINDING   258   258        NADP (By similarity). 
BINDING   326   326        NADP; via amide nitrogen and carbonyl oxygen (By similarity). 
SITE   139   139  1     Critical for catalysis (By similarity). 
SITE   210   210  1     Critical for catalysis (By similarity). 
MOD_RES   94    94        Phosphoserine (By similarity). 
Sequence information
Length: 406 AA [This is the length of the unprocessed precursor] Molecular weight: 45483 Da [This is the MW of the unprocessed precursor] CRC64: 093F7E18303A89E7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAKIKVKNPV VEIDGDEMTR IIWEWIRERL ILPYLDVDLK YYDLSVEKRD ETSDQITIDA 

        70         80         90        100        110        120 
ANAIKEYGVG VKCATITPDE ARVEEFGLKK MWKSPNGTIR NILGGVVFRE PIVIKNVPRL 

       130        140        150        160        170        180 
VPGWTDPIVV GRHAFGDQYK ATDFKVPGAG TLTMKWVGTN GEELEYEVFE FPSAGVAMGM 

       190        200        210        220        230        240 
YNLDESIRDF AKASFNYGLN RGWPVYLSTK NTILKAYDGR FKDLFQEVFD AEFADKFKAA 

       250        260        270        280        290        300 
GIVYEHRLID DMVASALKWS GKFVWACKNY DGDVQSDTVA QGFGSLGLMT SVLLSPDGKT 

       310        320        330        340        350        360 
VEAEAAHGTV TRHYRQHQQG KATSTNPIAS IFAWTQGLSF RGKFDDTPDV VKFAETLEQV 

       370        380        390        400 
CIKTVEGGAM TKDLALLIGP DQAWMTTEQF FEAIRVNLEA EMAKWA
P50215 in FASTA format

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