[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A AND 1B). TISSUE=Peripheral blood; PubMed=8486659 [NCBI, ExPASy, EBI, Israel, Japan] Parruti G., Peracchia F., Sallese M., Ambrosini G., Masini M., Rotilio D., de Blasi A.; "Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing."; J. Biol. Chem. 268:9753-9761(1993).
[2]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A AND 1B). TISSUE=Brain; Yu Q.M., Zhou T.H., Cheng Z.J., Ma L., Pei G.; "Molecular cloning of two isoforms of human beta-arrestin 1."; Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
[3]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. NHLBI resequencing and genotyping service (RS&G); Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
[4]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A). TISSUE=Uterus; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[5]	IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY. Colinge J., Superti-Furga G., Bennett K.L.; Submitted (OCT-2008) to UniProtKB.

Comments

FUNCTION: Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.
INTERACTION:
O00203:AP3B1; NbExp=1; IntAct=EBI-743313, EBI-1044383;
P36575:ARR3; NbExp=1; IntAct=EBI-743313, EBI-718116;
P32121:ARRB2; NbExp=1; IntAct=EBI-743313, EBI-714559;
Q14137:BOP1; NbExp=1; IntAct=EBI-743313, EBI-1050828;
P62158:CALM1; NbExp=1; IntAct=EBI-743313, EBI-397435;
Q16627:CCL14; NbExp=1; IntAct=EBI-743313, EBI-1046947;
Q96DG6:CMBL; NbExp=1; IntAct=EBI-743313, EBI-1044268;
P68400:CSNK2A1; NbExp=1; IntAct=EBI-743313, EBI-347804;
Q96GQ7:DDX27; NbExp=1; IntAct=EBI-743313, EBI-722051;
P06396:GSN; NbExp=1; IntAct=EBI-743313, EBI-351506;
Q7Z4V5:HDGFRP2; NbExp=1; IntAct=EBI-743313, EBI-1049136;
P11142:HSPA8; NbExp=1; IntAct=EBI-743313, EBI-351896;
P50053:KHK; NbExp=1; IntAct=EBI-743313, EBI-1053974;
O00505:KPNA3; NbExp=1; IntAct=EBI-743313, EBI-358297;
P19338:NCL; NbExp=1; IntAct=EBI-743313, EBI-352553;
Q14978:NOLC1; NbExp=2; IntAct=EBI-743313, EBI-396155;
O00541:PES1; NbExp=1; IntAct=EBI-743313, EBI-1053271;
P14618:PKM2; NbExp=1; IntAct=EBI-743313, EBI-353408;
P35813:PPM1A; NbExp=1; IntAct=EBI-743313, EBI-989143;
O75688:PPM1B; NbExp=1; IntAct=EBI-743313, EBI-1047039;
Q13523:PRPF4B; NbExp=1; IntAct=EBI-743313, EBI-395940;
Q6DKI1:RPL7L1; NbExp=1; IntAct=EBI-743313, EBI-1052408;
Q92541:RTF1; NbExp=1; IntAct=EBI-743313, EBI-1055239;
P06702:S100A9; NbExp=1; IntAct=EBI-743313, EBI-1055001;
Q15208:STK38; NbExp=1; IntAct=EBI-743313, EBI-458376;
Q13428:TCOF1; NbExp=2; IntAct=EBI-743313, EBI-396105;
P27348:YWHAQ; NbExp=1; IntAct=EBI-743313, EBI-359854;
O95218:ZRANB2; NbExp=2; IntAct=EBI-743313, EBI-1051583;
ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.

Name 1A

Isoform ID P49407-1

This is the isoform sequence displayed in this entry.

Name 1B

Isoform ID P49407-2

Features which should be applied to build the isoform sequence: VSP_000322.
SIMILARITY: Belongs to the arrestin family.
WEB RESOURCE: Name=Wikipedia; Note=Arrestin entry; URL="http://en.wikipedia.org/wiki/Arrestin";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L04685; AAA35559.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
L04685; AAA35558.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF084040; AAC33295.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF084940; AAC34123.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
DQ314865; ABC40724.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC003636; AAH03636.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00293857; -.
IPI00336017; -.

PIR

B46682; B46682.

RefSeq

NP_004032.2; -.
NP_064647.1; -.

UniGene

Hs.503284

3D structure databases

PDB

2IV8; X-ray; 2.80 A; P/Q=383-402.

[ExPASy / RCSB / EBI]

PDBsum

2IV8; -.

ModBase

P49407.

Protein-protein interaction databases

IntAct

P49407; 189.

PTM databases

PhosphoSite

P49407; -.

Enzyme and pathway databases

Pathway_Interaction_DB

arf6cyclingpathway; Arf6 signaling events.

Reactome

REACT_11123; Membrane Trafficking.

2D gel databases

OGP

P49407; -.

Organism-specific databases

GC11M074654; -.

HIX0009944; -.

HGNC:711; ARRB1.

CAB003763; -.

107940; gene. [NCBI / EBI]

PharmGKB

PA59; -.

Gene expression databases

P49407; -.

P49407; -.

HS_ARRB1; -.

ENSG00000137486; Homo sapiens.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from direct assay from UniProtKB).
GO:0005624;	Cellular component: membrane fraction (inferred from direct assay from UniProtKB).
GO:0005886;	Cellular component: plasma membrane (traceable author statement from ProtInc).
GO:0005625;	Cellular component: soluble fraction (traceable author statement from UniProtKB).
GO:0004857;	Molecular function: enzyme inhibitor activity (traceable author statement from ProtInc).
GO:0005515;	Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0007165;	Biological process: signal transduction (traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR000698; Arrestin.
IPR011022; Arrestin-like_C.
IPR011021; Arrestin-like_N.
IPR014752; Arrestin_C.
IPR017864; Arrestin_CS.
IPR014753; Arrestin_N.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.40.640; Arrestin_C; 1.
G3DSA:2.60.40.840; Arrestin_N; 1.

PANTHER

PTHR11792; Arrestin; 1.

Pfam

PF02752; Arrestin_C; 1.
PF00339; Arrestin_N; 1.
Pfam graphical view of domain structure.

PRINTS

PR00309; ARRESTIN.

ProDom

PD002099; Arrestin; 2.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00295; ARRESTINS; 1.

Proteomic databases

PRIDE

P49407; -.

Genome annotation databases

Ensembl

ENSG00000137486; Homo sapiens. [Contig view]

GeneID

408; -.

KEGG

hsa:408; -.

Phylogenomic databases

HOGENOM

P49407; -.

HOVERGEN

P49407; -.

Other

1713; -.

ARRB1; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Alternative splicing; Phosphoprotein; Sensory transduction.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 418`	`418`	`Beta-arrestin-1.`	`PRO_0000205194`
`MOD_RES`	`47 47`		`Phosphotyrosine (By similarity).`
`MOD_RES`	`410 410`		`Phosphothreonine (By similarity).`
`MOD_RES`	`412 412`		`Phosphoserine (By similarity).`
`VAR_SEQ`	`334 341`		`Missing (in isoform 1B).`	`VSP_000322`
`CONFLICT`	`146 146`		`V -> A (in Ref. 1; AAA35559/AAA35558).`
`CONFLICT`	`165 165`		`R -> G (in Ref. 1; AAA35559/AAA35558).`
`CONFLICT`	`229 229`		`K -> E (in Ref. 1; AAA35559/AAA35558).`
`CONFLICT`	`329 329`		`V -> E (in Ref. 2; AAC33295/AAC34123).`
`CONFLICT`	`400 400`		`K -> E (in Ref. 1; AAA35559/AAA35558).`
`CONFLICT`	`414 414`		`Q -> R (in Ref. 1; AAA35559/AAA35558).`
`CONFLICT`	`417 417`		`N -> D (in Ref. 1; AAA35559/AAA35558).`
`HELIX`	`384 394`	`11`

Sequence information

Length: 418 AA [This is the length of the unprocessed precursor]

Molecular weight: 47066 Da [This is the MW of the unprocessed precursor]

CRC64: 0A3C135092338D10 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGDKGTRVFK KASPNGKLTV YLGKRDFVDH IDLVDPVDGV VLVDPEYLKE RRVYVTLTCA 

        70         80         90        100        110        120 
FRYGREDLDV LGLTFRKDLF VANVQSFPPA PEDKKPLTRL QERLIKKLGE HAYPFTFEIP 

       130        140        150        160        170        180 
PNLPCSVTLQ PGPEDTGKAC GVDYEVKAFC AENLEEKIHK RNSVRLVIRK VQYAPERPGP 

       190        200        210        220        230        240 
QPTAETTRQF LMSDKPLHLE ASLDKEIYYH GEPISVNVHV TNNTNKTVKK IKISVRQYAD 

       250        260        270        280        290        300 
ICLFNTAQYK CPVAMEEADD TVAPSSTFCK VYTLTPFLAN NREKRGLALD GKLKHEDTNL 

       310        320        330        340        350        360 
ASSTLLREGA NREILGIIVS YKVKVKLVVS RGGLLGDLAS SDVAVELPFT LMHPKPKEEP 

       370        380        390        400        410 
PHREVPENET PVDTNLIELD TNDDDIVFED FARQRLKGMK DDKEEEEDGT GSPQLNNR

P49407 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools