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UniProtKB/Swiss-Prot entry P49349


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FPPS_KLULA
Primary accession number P49349
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on February 1, 1996 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 55)
Name and origin of the protein
Protein name Farnesyl pyrophosphate synthetase
Synonyms FPP synthetase
FPS
Farnesyl diphosphate synthetase
Includes Dimethylallyltranstransferase
     (EC 2.5.1.1)
Geranyltranstransferase
     (EC 2.5.1.10)
Gene name
Name: FPS1
Synonyms: FPS
OrderedLocusNames: KLLA0A06732g
From
Kluyveromyces lactis (Yeast) (Candida sphaerica) [TaxID: 28985] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37;
DOI=10.1016/0167-4781(94)90234-8; PubMed=7948032 [NCBI, ExPASy, EBI, Israel, Japan]
Mulder W., Scholten I.H.J.M., Nagelkerken B., Grivell L.A.;
"Isolation and characterisation of the linked genes, FPS1 and QCR8, coding for farnesyl-diphosphate synthase and the 11 kDa subunit VIII of the mitochondrial bc1-complex in the yeast Kluyveromyces lactis.";
Biochim. Biophys. Acta 1219:713-718(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37;
DOI=10.1038/nature02579; PubMed=15229592 [NCBI, ExPASy, EBI, Israel, Japan]
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.;
"Genome evolution in yeasts.";
Nature 430:35-44(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X76026; CAA53614.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR382121; CAH02888.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S50214; S50214.
RefSeq XP_451300.1; -.
3D structure databases
HSSP P08836; 1UBY. [HSSP ENTRY / PDB]
ModBase P49349.
Family and domain databases
InterPro IPR000092; Polyprenyl_synt.
IPR008949; Terpenoid_synth.
Graphical view of domain structure.
Gene3D G3DSA:1.10.600.10; Terpenoid_synth; 1.
Pfam PF00348; polyprenyl_synt; 1.
Pfam graphical view of domain structure.
PROSITE PS00723; POLYPRENYL_SYNTHET_1; 1.
PS00444; POLYPRENYL_SYNTHET_2; 1.
BLOCKS P49349.
Genome annotation databases
GeneID 2896751; -.
KEGG kla:KLLA0A06732g; -.
Phylogenomic databases
HOGENOM P49349; -.
Other
ProtoNet P49349.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cholesterol biosynthesis; Complete proteome; Cytoplasm; Isoprene biosynthesis; Lipid synthesis; Steroid biosynthesis; Sterol biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   349  349     Farnesyl pyrophosphate synthetase. PRO_0000123949
ACT_SITE   186   186        By similarity. 
Sequence information
Length: 349 AA [This is the length of the unprocessed precursor] Molecular weight: 40157 Da [This is the MW of the unprocessed precursor] CRC64: 290557C17FAACDCE [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSDNRAQFLE VFPSLVQELR DILAGYGMPE EAIEWYEKSL NYNTPGGKLN RGLSVVDTYA 

        70         80         90        100        110        120 
LLKGYKSVSE LSAEEYKKVA ILGWCIELLQ AYFLVADDMM DQSITRRGQP CWYKVENVGD 

       130        140        150        160        170        180 
IAINDAFMLE GAIYCLLKKH FRTEPYYVDL LELFHDVTFQ TELGQLLDLI TAPEDKVDLS 

       190        200        210        220        230        240 
KFSLEKHSFI VIFKTAYYSF YLAVALAMFA AGITDSKDLK QASDVLIPLG EYFQIQDDFL 

       250        260        270        280        290        300 
DCFGKPEDIG KIGTDIQDNK CSWVINVALK NATKEQRDIL DENYGRKDSE KEQKCRAVFN 

       310        320        330        340 
ELNIQDIYHK YEEETASNLR EKIANIDESR GFKAEVLTLF LNKIYHRKK 

P49349 in FASTA format

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View entry in raw text format (no links)
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