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UniProtKB/Swiss-Prot entry P49221

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TGM4_HUMAN
Primary accession number P49221
Secondary accession numbers Q16707 Q96QN4
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on December 15, 1998 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 79)
Name and origin of the protein
Protein name Protein-glutamine gamma-glutamyltransferase 4
Synonyms EC 2.3.2.13
Transglutaminase-4
TGase-4
Prostate transglutaminase
TGP
TG(P)
Prostate-specific transglutaminase
Fibrinoligase
Gene name
Name: TGM4
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Prostate;
DOI=10.1006/bbrc.1994.2298; PubMed=7916568 [NCBI, ExPASy, EBI, Israel, Japan]
Grant F.J., Taylor D.A., Sheppard P.O., Mathewes S.L., Lint W., Vanaja E., Bishop P.D., O'Hara P.J.;
"Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library.";
Biochem. Biophys. Res. Commun. 203:1117-1123(1994).
[2]
 SEQUENCE REVISION.
Grant F.J.;
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
[3]
 NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
TISSUE=Prostate;
PubMed=8645175 [NCBI, ExPASy, EBI, Israel, Japan]
Dubbink H.J., Verkaik N.S., Faber P.W., Trapman J., Schroeder F.H., Romijn J.C.;
"Tissue specific and androgen-regulated expression of human prostate-specific transglutaminase.";
Biochem. J. 315:901-908(1996).
[4]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Prostate;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L34840; AAB95430.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U31905; AAC50516.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC007003; AAH07003.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S71105; S71105.
RefSeq NP_003232.2; -.
UniGene Hs.438265
3D structure databases
HSSP Q08188; 1L9M. [HSSP ENTRY / PDB]
ModBase P49221.
Protein-protein interaction databases
IntAct P49221; -.
PTM databases
PhosphoSite P49221; -.
Organism-specific databases
H-InvDB HIX0003228; -.
HGNC HGNC:11780; TGM4.
GenAtlas TGM4.
MIM 600585; gene. [NCBI / EBI]
PharmGKB PA36493; -.
GeneCards P49221.
Gene expression databases
ArrayExpress P49221; -.
CleanEx HS_TGM4; -.
GermOnline ENSG00000163810; Homo sapiens.
Ontologies
GO
GO:0003810; Molecular function: protein-glutamine gamma-glutamyltransferase activity (non-traceable author statement from UniProtKB).
GO:0018149; Biological process: peptide cross-linking (non-traceable author statement from UniProtKB).
GO:0018184; Biological process: protein amino acid polyamination (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR008957; Fibronectin_typ-III-like_fold.
IPR013783; Ig-like_fold.
IPR008958; Transglutaminase_C.
IPR013808; Transglutaminase_CS.
IPR001102; Transglutaminase_N.
IPR002931; Trnsglumase_like.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.30; FN_III-like; 1.
G3DSA:2.60.40.10; Ig-like_fold; 1.
Pfam PF00927; Transglut_C; 1.
PF01841; Transglut_core; 1.
PF00868; Transglut_N; 1.
Pfam graphical view of domain structure.
SMART SM00460; TGc; 1.
SMART graphical view of domain structure.
PROSITE PS00547; TRANSGLUTAMINASES; 1.
BLOCKS P49221.
Genome annotation databases
Ensembl ENSG00000163810; Homo sapiens. [Contig view]
GeneID 7047; -.
KEGG hsa:7047; -.
Phylogenomic databases
HOGENOM P49221; -.
HOVERGEN P49221; -.
Other
DrugBank DB00130; L-Glutamine.
SOURCE TGM4; Homo sapiens.
ProtoNet P49221.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acyltransferase; Calcium; Metal-binding; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   684  684     Protein-glutamine gamma-glutamyltransferase 4. PRO_0000213711
ACT_SITE   268   268        By similarity. 
ACT_SITE   327   327        By similarity. 
ACT_SITE   350   350        By similarity. 
METAL   390   390        Calcium (By similarity). 
METAL   392   392        Calcium (By similarity). 
METAL   442   442        Calcium (By similarity). 
METAL   447   447        Calcium (By similarity). 
CONFLICT   313   313        E -> K (in Ref. 3; AAC50516). 
CONFLICT   353   353        P -> S (in Ref. 4; AAH07003). 
Sequence information
Length: 684 AA [This is the length of the unprocessed precursor] Molecular weight: 77145 Da [This is the MW of the unprocessed precursor] CRC64: 64A3E754EA46BFEC [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MMDASKELQV LHIDFLNQDN AVSHHTWEFQ TSSPVFRRGQ VFHLRLVLNQ PLQSYHQLKL 

        70         80         90        100        110        120 
EFSTGPNPSI AKHTLVVLDP RTPSDHYNWQ ATLQNESGKE VTVAVTSSPN AILGKYQLNV 

       130        140        150        160        170        180 
KTGNHILKSE ENILYLLFNP WCKEDMVFMP DEDERKEYIL NDTGCHYVGA ARSIKCKPWN 

       190        200        210        220        230        240 
FGQFEKNVLD CCISLLTESS LKPTDRRDPV LVCRAMCAMM SFEKGQGVLI GNWTGDYEGG 

       250        260        270        280        290        300 
TAPYKWTGSA PILQQYYNTK QAVCFGQCWV FAGILTTVLR ALGIPARSVT GFDSAHDTER 

       310        320        330        340        350        360 
NLTVDTYVNE NGEKITSMTH DSVWNFHVWT DAWMKRPDLP KGYDGWQAVD ATPQERSQGV 

       370        380        390        400        410        420 
FCCGPSPLTA IRKGDIFIVY DTRFVFSEVN GDRLIWLVKM VNGQEELHVI SMETTSIGKN 

       430        440        450        460        470        480 
ISTKAVGQDR RRDITYEYKY PEGSSEERQV MDHAFLLLSS EREHRRPVKE NFLHMSVQSD 

       490        500        510        520        530        540 
DVLLGNSVNF TVILKRKTAA LQNVNILGSF ELQLYTGKKM AKLCDLNKTS QIQGQVSEVT 

       550        560        570        580        590        600 
LTLDSKTYIN SLAILDDEPV IRGFIIAEIV ESKEIMASEV FTSFQYPEFS IELPNTGRIG 

       610        620        630        640        650        660 
QLLVCNCIFK NTLAIPLTDV KFSLESLGIS SLQTSDHGTV QPGETIQSQI KCTPIKTGPK 

       670        680 
KFIVKLSSKQ VKEINAQKIV LITK
P49221 in FASTA format

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