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UniProtKB/Swiss-Prot entry P49015

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ATP7A_CRIGR
Primary accession number P49015
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on February 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 66)
Name and origin of the protein
Protein name Copper-transporting ATPase 1 [Fragment]
Synonyms EC 3.6.3.4
Copper pump 1
Gene name
Name: ATP7A
From
Cricetulus griseus (Chinese hamster) [TaxID: 10029] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Cricetidae; Cricetinae; Cricetulus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Ovary;
DOI=10.1093/hmg/4.11.2117; PubMed=8589689 [NCBI, ExPASy, EBI, Israel, Japan]
Camakaris J., Petris M.J., Bailey L., Shen P., Lockhart P., Glover T.W., Barcroft C., Patton J., Mercer J.F.B.;
"Gene amplification of the Menkes (MNK; ATP7A) P-type ATPase gene of CHO cells is associated with copper resistance and enhanced copper efflux.";
Hum. Mol. Genet. 4:2117-2123(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U29946; AAB39918.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP Q04656; 1AW0. [HSSP ENTRY / PDB]
SMR P49015; 1-79, 164-246, 274-350, 374-445.
ModBase P49015.
Family and domain databases
InterPro IPR006416; ATPase-IB_hvy.
IPR001757; ATPase_P.
IPR006403; ATPase_P_cat/Cu.
IPR001877; Cu_ATPase1.
IPR006122; Cu_ion_bd.
IPR005834; Dehalogen-like_hydro.
IPR008250; E1-E2_ATPase_reg.
IPR006121; HeavyMe_transpt.
Graphical view of domain structure.
PANTHER PTHR11939; ATPase_P; 1.
Pfam PF00122; E1-E2_ATPase; 1.
PF00403; HMA; 6.
PF00702; Hydrolase; 1.
Pfam graphical view of domain structure.
PRINTS PR00119; CATATPASE.
PR00942; CUATPASEI.
TIGRFAMs TIGR01511; ATPase-IB1_Cu; 1.
TIGR01525; ATPase-IB_hvy; 1.
TIGR01494; ATPase_P-type; 2.
TIGR00003; Cu_ion_bd; 2.
PROSITE PS00154; ATPASE_E1_E2; 1.
PS01047; HMA_1; 5.
PS50846; HMA_2; 6.
PROSITE graphical view of domain structure (profiles).
BLOCKS P49015.
Phylogenomic databases
HOVERGEN P49015; -.
Other
ProtoNet P49015.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Copper; Copper transport; Glycoprotein; Hydrolase; Ion transport; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Repeat; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   >1476  >1476     Copper-transporting ATPase 1. PRO_0000046310
TOPO_DOM   1     642  642     Cytoplasmic (Potential). 
TRANSMEM   643     665  23     Potential. 
TRANSMEM   695     717  23     Potential. 
TRANSMEM   736     760  25     Potential. 
TRANSMEM   770     788  19     Potential. 
TRANSMEM   930     952  23     Potential. 
TRANSMEM   978     998  21     Potential. 
TRANSMEM   1347    1373  27     Potential. 
TRANSMEM   1379    1397  19     Potential. 
DOMAIN   9      75  67     HMA 1. 
DOMAIN   172     238  67     HMA 2. 
DOMAIN   277     343  67     HMA 3. 
DOMAIN   377     443  67     HMA 4. 
DOMAIN   479     545  67     HMA 5. 
DOMAIN   555     621  67     HMA 6. 
ACT_SITE   1034    1034        4-aspartylphosphate intermediate (Probable). 
MOD_RES   352     352        Phosphoserine (By similarity). 
MOD_RES   355     355        Phosphoserine (By similarity). 
MOD_RES   356     356        Phosphoserine (By similarity). 
CARBOHYD   674     674        N-linked (GlcNAc...) (Potential). 
CARBOHYD   685     685        N-linked (GlcNAc...) (Potential). 
CARBOHYD   887     887        N-linked (GlcNAc...) (Potential). 
CARBOHYD   953     953        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1130    1130        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1134    1134        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1448    1448        N-linked (GlcNAc...) (Potential). 
NON_TER   1476    1476         
Sequence information
Length: 1476 AA [This is the length of the partial sequence of the unprocessed precursor] Molecular weight: 160336 Da [This is the MW of the partial sequence of the unprocessed precursor] CRC64: 6B36F5A2AC358C0B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEPSMDVNSV TISVEGMTCI SCVRTIEQKI GKENGIHHIK VSLEEKSATI IYDPKLQTPK 

        70         80         90        100        110        120 
TLQEAIDDMG FDALLHNANP LPVLTDTLFL TVTASLTLPW DHIQSTLLKT KGVTDIKIFP 

       130        140        150        160        170        180 
QKRTLAVTII PSIVNANQIK ELVPELSLET GTLEKRSGAC EDHSMAQAGE VVLKIKVEGM 

       190        200        210        220        230        240 
TCHSCTSTTE GKIGKLQGVQ RIKVSLDNQE ATIVYQPHLI SVEEIKKQIE AMGFPAFVKK 

       250        260        270        280        290        300 
QPKYLKLGAI DVERLKNTPV KSLEGSQQRP SYPSDSTATF IIEGMHCKSC VSNIESALPT 

       310        320        330        340        350        360 
LQYVSSIAVS LENRSAIVKY NASSVTPEML IKAIEAVSPG QYRVSIANEV ESTSSSPSSS 

       370        380        390        400        410        420 
SLQKMPLNVV SQPLTQETVI NISGMTCNSC VQSIEGVVSK KPGVKSIHVS LANSFGTVEY 

       430        440        450        460        470        480 
DPLLTAPETL REVIVDMGFD AVLPDMSEPL VVIAQPSLET PLLPSTNDQD NMMTAVHSKC 

       490        500        510        520        530        540 
YIQVSGMTCA SCVANIERNL RREEGIYSVL VALMAGKAEV RYNPAVIQPP VIAEFIRELG 

       550        560        570        580        590        600 
FGATVMENAD EGDGILKLVV RGMTCASCVH KIESTLTKHK GIFYCSVALA TNKAHIKYDP 

       610        620        630        640        650        660 
EIIGPRDIIH TIGSLGFEAS LVKKDRSASH LDHKREIKQW RSSFLVSLFF CTPVMGLMMY 

       670        680        690        700        710        720 
MMAMEHHFAT IHHNQSMSNE EMIKNHSSMF LERQILPGLS IMNLLSLLLC LPVQFFGGWY 

       730        740        750        760        770        780 
FYIQAYKALK HKTANMDVLI VLATTIAFAY SLIILLVAMY ERAKVNPITS FDTPPMLFVF 

       790        800        810        820        830        840 
IALGRWLEHI AKGKTSEALA KLISLQATEA TIVTLDSDNI LLSEEQVDVE LVQRGDIIKV 

       850        860        870        880        890        900 
VPGGKFPVDG RVIEGHSMVD ESLITGEAMP VAKKPGSTVI AGSINQNGSL LICATHVGAD 

       910        920        930        940        950        960 
TTLSQIVKLV EEAQTSKAPI QQFADKLGGY FVPFIVLVSI ATLLVWIIIG FQNFTIVETY 

       970        980        990       1000       1010       1020 
FPGYSRSISR TETIIRFAFQ ASITVLCIAC PCSLGLATPT AVMVGTGVGA QNGILIKGGE 

      1030       1040       1050       1060       1070       1080 
PLEMAHKVKV VVFDKTGTIT HGTPVVNQVK VLVESNKIPR SKILAIVGTA ESNSEHPLGA 

      1090       1100       1110       1120       1130       1140 
AVTKYCKQEL DTETLGTCTD FQVVPGCGIS CKVTNIEGLL HKSNLKIEEN NTKNASLVQI 

      1150       1160       1170       1180       1190       1200 
DAINEQSSTS SSMIIDAPLS NAVDTQQYKV LIGNREWMIR NGLVISNDVD DSMIDHGRKG 

      1210       1220       1230       1240       1250       1260 
RPAVLVTIDD ELCGLIAIAD TVKPEAELAV HILKSMGLEV VLMTGDNSKT ARSIASQVGI 

      1270       1280       1290       1300       1310       1320 
TKVFAEVLPS HKVAKVKQLQ EEGKRVAMVG DGINDSPALA MANVGIAIGT GTDVTIEAAD 

      1330       1340       1350       1360       1370       1380 
VVFIRNDLLD VVASIDLSRK TVKRIRINFL FPLIYNLVGI PIAAGVFLPI GLVFQPWMGS 

      1390       1400       1410       1420       1430       1440 
AAMAASSVSV VLSSLFLKLY RKPTYDNYEL RTRSHTGQRS PSEISVHVGI DDASRNSPRL 

      1450       1460       1470 
GLLDRIVNYS RASINSLLSD KRSLNSVVNS EPDKHS
P49015 in FASTA format

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