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UniProtKB/Swiss-Prot entry P48741


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HSP77_HUMAN
Primary accession number P48741
Secondary accession number P19790
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on September 11, 2007 (Sequence version 2)
Annotations were last modified on    May 5, 2009 (Entry version 64)
Name and origin of the protein
Protein name Putative heat shock 70 kDa protein 7
Synonym Heat shock 70 kDa protein B
Gene name
Name: HSPA7
Synonyms: HSP70B
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 5: Uncertain;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-247.
DOI=10.1073/pnas.82.15.4949; PubMed=3927293 [NCBI, ExPASy, EBI, Israel, Japan]
Voellmy R., Ahmed A., Schiller P., Bromley P., Rungger D.;
"Isolation and functional analysis of a human 70,000-dalton heat shock protein gene segment.";
Proc. Natl. Acad. Sci. U.S.A. 82:4949-4953(1985).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL451067; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
M11236; AAA52696.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00011134; -.
PIR A25773; A25773.
UniGene Hs.690634
3D structure databases
HSSP P08107; 1HJO. [HSSP ENTRY / PDB]
SMR P48741; 8-247.
ModBase P48741.
PTM databases
PhosphoSite P48741; -.
Organism-specific databases
GeneCards GC01U990091; -.
H-InvDB HIX0056994; -.
HGNC HGNC:5240; HSPA7.
GenAtlas HSPA7.
MIM 140556; gene. [NCBI / EBI]
PharmGKB PA29506; -.
Gene expression databases
GermOnline ENSG00000203745; Homo sapiens.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (non-traceable author statement from UniProtKB).
GO:0006986; Biological process: response to unfolded protein (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR018181; Heat_shock_70_CS.
IPR001023; Hsp70.
IPR013126; Hsp_70.
Graphical view of domain structure.
Pfam PF00012; HSP70; 1.
Pfam graphical view of domain structure.
PRINTS PR00301; HEATSHOCK70.
PROSITE PS00297; HSP70_1; 1.
PS00329; HSP70_2; 1.
PS01036; HSP70_3; PARTIAL.
Proteomic databases
PRIDE P48741; -.
Phylogenomic databases
HOGENOM P48741; -.
HOVERGEN P48741; -.
Other
SOURCE HSPA7; Homo sapiens.
ProtoNet P48741.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Nucleotide-binding; Stress response.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   367  367     Putative heat shock 70 kDa protein 7. PRO_0000078267
CONFLICT   59    59        S -> N (in Ref. 2; AAA52696). 
CONFLICT   95    95        Q -> K (in Ref. 2; AAA52696). 
CONFLICT   99    99        E -> G (in Ref. 2; AAA52696). 
CONFLICT   127   127        S -> T (in Ref. 2; AAA52696). 
CONFLICT   191   191        G -> R (in Ref. 2; AAA52696). 
CONFLICT   213   213        S -> T (in Ref. 2; AAA52696). 
Sequence information
Length: 367 AA [This is the length of the unprocessed precursor] Molecular weight: 40244 Da [This is the MW of the unprocessed precursor] CRC64: 060DFA210A29A5D4 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MQAPRELAVG IDLGTTYSCV GVFQQGRVEI LANDQGNRTT PSYVAFTDTE RLVGDAAKSQ 

        70         80         90        100        110        120 
AALNPHNTVF DAKRLIGRKF ADTTVQSDMK HWPFQVVSEG GKPKVRVCYR GEDKTFYPEE 

       130        140        150        160        170        180 
ISSMVLSKMK ETAEAYLGQP VKHAVITVPT YFSNSQRQAT KDAGAIAGLK VLPIINEATA 

       190        200        210        220        230        240 
AAIAYGLDRR GAGKRNVLIF DLGGGTFDVS VLSIDAGVFE VKATAGDTHL GGEDFDNRLV 

       250        260        270        280        290        300 
NHFMEEFRRK HGKDLSGNKR ALRRLRTACE RAKRTPSSST QATLEIDSLF EGVDFYKSIT 

       310        320        330        340        350        360 
RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDFVLGG GLHSHPQGAE VAAGLLQRQG 


AEQEHQP 

P48741 in FASTA format

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