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UniProtKB/Swiss-Prot entry P47928


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ID4_HUMAN
Primary accession number P47928
Secondary accession number Q13005
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on February 1, 1996 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 78)
Name and origin of the protein
Protein name DNA-binding protein inhibitor ID-4
Synonym Inhibitor of DNA binding 4
Gene name
Name: ID4
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Abdominal adipose tissue;
Kiesling T.L., Christy B.A.;
Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1093/dnares/5.5.309; PubMed=9872455 [NCBI, ExPASy, EBI, Israel, Japan]
Rigolet M., Rich T., Gross-Morand M.S., Molina-Gomes D., Viegas-Pequignot E., Junien C.;
"cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene.";
DNA Res. 5:309-313(1998).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1006/geno.1995.1026; PubMed=7665172 [NCBI, ExPASy, EBI, Israel, Japan]
Pagliuca A., Bartoli P.C., Saccone S., Della Valle G., Lania L.;
"Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22.";
Genomics 27:200-203(1995).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02055; PubMed=14574404 [NCBI, ExPASy, EBI, Israel, Japan]
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U28368; AAA73923.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y07958; CAA69255.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U16153; AAA82882.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL022726; CAA18779.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC014941; AAH14941.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00026864; -.
PIR G01855; G01855.
JE0306; JE0306.
RefSeq NP_001537.1; -.
UniGene Hs.519601
3D structure databases
ModBase P47928.
Protein-protein interaction databases
IntAct P47928; 6.
Organism-specific databases
GeneCards GC06P019945; -.
H-InvDB HIX0005610; -.
HGNC HGNC:5363; ID4.
GenAtlas ID4.
MIM 600581; gene. [NCBI / EBI]
PharmGKB PA29611; -.
Gene expression databases
ArrayExpress P47928; -.
Bgee P47928; -.
CleanEx HS_ID4; -.
GermOnline ENSG00000172201; Homo sapiens.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred by curator from GDB).
GO:0003714; Molecular function: transcription corepressor activity (traceable author statement from ProtInc).
GO:0016481; Biological process: negative regulation of transcription (inferred from direct assay from GDB).
GO:0006357; Biological process: regulation of transcription from RNA polymerase II promoter (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR001092; HLH_basic.
Graphical view of domain structure.
Pfam PF00010; HLH; 1.
Pfam graphical view of domain structure.
SMART SM00353; HLH; 1.
SMART graphical view of domain structure.
PROSITE PS50888; HLH; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE P47928; -.
Genome annotation databases
Ensembl ENSG00000172201; Homo sapiens. [Contig view]
GeneID 3400; -.
KEGG hsa:3400; -.
Phylogenomic databases
HOGENOM P47928; -.
HOVERGEN P47928; -.
OMA P47928; GACPVAP.
Other
NextBio 13436; -.
SOURCE ID4; Homo sapiens.
ProtoNet P47928.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Nucleus.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   161  161     DNA-binding protein inhibitor ID-4. PRO_0000127250
DOMAIN   65   105  41     Helix-loop-helix motif. 
COMPBIAS   39    48  10     Poly-Ala. 
COMPBIAS   118   124  7     Poly-Pro. 
CONFLICT   10    14        SGRKA -> RPLR (in Ref. 3; AAA82882). 
CONFLICT   39    40        AA -> Q (in Ref. 3; AAA82882). 
CONFLICT   77    79        RLV -> WL (in Ref. 3; AAA82882). 
Sequence information
Length: 161 AA [This is the length of the unprocessed precursor] Molecular weight: 16622 Da [This is the MW of the unprocessed precursor] CRC64: 5B14847AE7337339 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC KAAEAAADEP 

        70         80         90        100        110        120 
ALCLQCDMND CYSRLRRLVP TIPPNKKVSK VEILQHVIDY ILDLQLALET HPALLRQPPP 

       130        140        150        160 
PAPPHHPAGT CPAAPPRTPL TALNTDPAGA VNKQGDSILC R 

P47928 in FASTA format

View entry in raw text format (no links)
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