ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P47869


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name GBRA2_HUMAN
Primary accession number P47869
Secondary accession number Q59G14
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on February 20, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 79)
Name and origin of the protein
Protein name Gamma-aminobutyric acid receptor subunit alpha-2 [Precursor]
Synonym GABA(A) receptor subunit alpha-2
Gene name
Name: GABRA2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=8391122 [NCBI, ExPASy, EBI, Israel, Japan]
Hadingham K.L., Wingrove P., le Bourdelles B., Palmer K.J., Ragan C.I., Whiting P.J.;
"Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors.";
Mol. Pharmacol. 43:970-975(1993).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.;
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
[3]
INVOLVEMENT IN SUSCEPTIBILITY TO ALCOHOLISM.
DOI=10.1086/383283; PubMed=15024690 [NCBI, ExPASy, EBI, Israel, Japan]
Edenberg H.J., Dick D.M., Xuei X., Tian H., Almasy L., Bauer L.O., Crowe R.R., Goate A., Hesselbrock V., Jones K., Kwon J., Li T.-K., Nurnberger J.I. Jr., O'Connor S.J., Reich T., Rice J., Schuckit M.A., Porjesz B., Foroud T., Begleiter H.;
"Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations.";
Am. J. Hum. Genet. 74:705-714(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
S62907; AAB27278.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB209295; BAD92532.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I57947; I57947.
RefSeq NP_000798.2; -.
NP_001107647.1; -.
UniGene Hs.116250
3D structure databases
ModBase P47869.
Organism-specific databases
H-InvDB HIX0004189; -.
HGNC HGNC:4076; GABRA2.
GenAtlas GABRA2.
HPA HPA014261; -.
MIM 103780; phenotype. [NCBI / EBI]
137140; gene. [NCBI / EBI]
PharmGKB PA28490; -.
GeneCards P47869.
Gene expression databases
ArrayExpress P47869; -.
CleanEx HS_GABRA2; -.
GermOnline ENSG00000151834; Homo sapiens.
Ontologies
GO
GO:0030285; Cellular component: integral to synaptic vesicle membrane (inferred from direct assay from UniProtKB).
GO:0008503; Molecular function: benzodiazepine receptor activity (inferred from mutant phenotype from UniProtKB).
GO:0007214; Biological process: gamma-aminobutyric acid signaling pathway (inferred from mutant phenotype from UniProtKB).
GO:0006836; Biological process: neurotransmitter transport (inferred from mutant phenotype from UniProtKB).
GO:0001505; Biological process: regulation of neurotransmitter levels (inferred from mutant phenotype from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR006028; GABAA_rcpt.
IPR001390; GABAAa_rcpt.
IPR005432; GABBAa2_rcpt.
IPR006029; Neu_channel_TM.
IPR006202; Neur_chan_lig_bd.
IPR006201; Neur_channel.
Graphical view of domain structure.
Gene3D G3DSA:2.70.170.10; Neur_chan_lig_bd; 1.
PANTHER PTHR18945; Neur_channel; 1.
Pfam PF02931; Neur_chan_LBD; 1.
PF02932; Neur_chan_memb; 1.
Pfam graphical view of domain structure.
PRINTS PR01079; GABAARALPHA.
PR01615; GABAARALPHA2.
PR00253; GABAARECEPTR.
PR00252; NRIONCHANNEL.
TIGRFAMs TIGR00860; LIC; 1.
PROSITE PS00236; NEUROTR_ION_CHANNEL; 1.
BLOCKS P47869.
Genome annotation databases
Ensembl ENSG00000151834; Homo sapiens. [Contig view]
GeneID 2555; -.
KEGG hsa:2555; -.
Phylogenomic databases
HOGENOM P47869; -.
HOVERGEN P47869; -.
Other
DrugBank DB00404; Alprazolam.
DB01558; Bromazepam.
DB00829; Diazepam.
DB00189; Ethchlorvynol.
DB01567; Fludiazepam.
DB01544; Flunitrazepam.
DB00690; Flurazepam.
DB00186; Lorazepam.
DB00371; Meprobamate.
DB00683; Midazolam.
LinkHub P47869; -.
SOURCE GABRA2; Homo sapiens.
ProtoNet P47869.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell junction; Cell membrane; Chloride; Chloride channel; Glycoprotein; Ion transport; Ionic channel; Membrane; Postsynaptic cell membrane; Signal; Synapse; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    28  28     Potential. 
CHAIN   29   451  423     Gamma-aminobutyric acid receptor subunit alpha-2. PRO_0000000433
TOPO_DOM   29   251  223     Extracellular (Probable). 
TRANSMEM   252   273  22     Probable. 
TRANSMEM   279   300  22     Probable. 
TRANSMEM   313   334  22     Probable. 
TOPO_DOM   335   419  85     Cytoplasmic (Probable). 
TRANSMEM   420   441  22     Probable. 
CARBOHYD   38    38        N-linked (GlcNAc...) (Potential). 
CARBOHYD   138   138        N-linked (GlcNAc...) (Potential). 
DISULFID   166   180        By similarity. 
CONFLICT   10    11        MQ -> IE (in Ref. 1; AAB27278). 
CONFLICT   343   343        A -> T (in Ref. 1; AAB27278). 
Sequence information
Length: 451 AA [This is the length of the unprocessed precursor] Molecular weight: 51326 Da [This is the MW of the unprocessed precursor] CRC64: 43F9F708B5A00FFD [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKTKLNIYNM QFLLFVFLVW DPARLVLANI QEDEAKNNIT IFTRILDRLL DGYDNRLRPG 

        70         80         90        100        110        120 
LGDSITEVFT NIYVTSFGPV SDTDMEYTID VFFRQKWKDE RLKFKGPMNI LRLNNLMASK 

       130        140        150        160        170        180 
IWTPDTFFHN GKKSVAHNMT MPNKLLRIQD DGTLLYTMRL TVQAECPMHL EDFPMDAHSC 

       190        200        210        220        230        240 
PLKFGSYAYT TSEVTYIWTY NASDSVQVAP DGSRLNQYDL LGQSIGKETI KSSTGEYTVM 

       250        260        270        280        290        300 
TAHFHLKRKI GYFVIQTYLP CIMTVILSQV SFWLNRESVP ARTVFGVTTV LTMTTLSISA 

       310        320        330        340        350        360 
RNSLPKVAYA TAMDWFIAVC YAFVFSALIE FATVNYFTKR GWAWDGKSVV NDKKKEKASV 

       370        380        390        400        410        420 
MIQNNAYAVA VANYAPNLSK DPVLSTISKS ATTPEPNKKP ENKPAEAKKT FNSVSKIDRM 

       430        440        450 
SRIVFPVLFG TFNLVYWATY LNREPVLGVS P 

P47869 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!